Xinrui Li, PhD

Xinrui_LiInstructor of Medicine 




Shelby Building, Room 206
1825 University Boulevard

Telephone:(205) 934-3727



BSc (Life Sciences), Fudan University, Shanghai, China, 2003
PhD, (Cell Biology), University of Alabama at Birmingham, 2009
Postdoctoral Fellow, Department of Medicine, Division of Clinical Immunology & Rheumatology, 2012


Research Description

Genetic variations in candidate genes that alter signaling properties/functions in normal immune system, as well as their potential contribution to autoimmune diseases and their underlying mechanism.



Li X, Gibson AW, Kimberly RP. 2014. Human FcR polymorphism and disease. Curr Top Microbiol Immunol. 382:275-302. PMID:25116105 PMCID: PMC 4209745

Li X, Kimberly RP. 2014. Targeting the Fc receptor in autoimmune disease. Expert Opin Ther Targets. 18(3):335-50. PMID:24521454 PMCID: PMC4019044

Li X, Wu J, Ptacek T, Redden DT, Brown EE, Alarcón GS, Ramsey-Goldman R, Petri MA, Reveille JD, Kaslow RA, Kimberly RP, Edberg JC. 2013. Allelic-dependent expression of an activating Fc receptor on B cells enhances humoral immune responses. Sci Transl Med. 5(216):216ra175.  PMID:24353158 PMCID: PMC3982386

Absher DM, Li X, Waite LL, Gibson A, Roberts K, Edberg J, Chatham WW, Kimberly RP. 2013. Genome-Wide DNA Methylation Analysis of Systemic Lupus Erythematosus Reveals Persistent Hypomethylation of Interferon Genes and Compositional Changes to CD4+ T-cell Populations. PLoS Genet. 9(8):e1003678.  PMID:23950730 PMCID: PMC3738443

Gibson AW, Li X, Wu J, Baskin JG, Raman C, Edberg JC, Kimberly RP. 2012. Serine phosphorylation of FcγRI cytoplasmic domain directs lipid raft localization and interaction with protein 4.1G. J Leukoc Biol. 91(1):97-103. PMID:22003208 PMCID: PMC3250306

Li X, Su K, Ji C, Szalai AJ, Wu J, Zhang Y, Zhou T, Kimberly RP, Edberg JC. 2008. Immune opsonins modulate BLyS/BAFF release in a receptorspecific fashion. J Immunol. 181(2):1012-8. PMID: 18606652 PMCID: PMC3684394

Li X, Ptacek TS, Brown EE, Edberg JC. 2009. Fcgamma receptors: structure, function and role as genetic risk factors in SLE. Genes Immun. Jul;10(5):380-9. PMID: 19421223 PMCID: PMC2830794

Ptacek T, Li X, Kelley JM, Edberg JC. 2008. Copy number variants in genetic susceptibility and severity of systemic lupus erythematosus. Cytogenet Genome Res. 123(1-4):142-7. PMID: 19287148 PMCID: PMC2826785

Su K, Yang H, Li X, Li X, Gibson AW, Cafardi JM, Zhou T, Edberg JC, Kimberly RP. 2007. Expression profile of FcgammaRIIb on leukocytes and its dysregulation in systemic lupus erythematosus. J Immunol. 178(5):3272-80. PMID: 17312177  PMCID: PMC2824439

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