Andre Ballesteros-Tato, PhD

Ballesteros_Tato_1Assistant Professor of Medicine

Division of Clinical Immunology and Rheumatology

Address:

Shelby Building, Room 511
1825 University Boulevard
35294

Telephone: (205) 975-4643

Fax: (205) 975-3322

Email: aballest@uab.edu

 

Education:

B.S. (Biology): Vigo University, Spain, 2001
Ph.D. (Microbiology & Immunology): Universidad Autonoma de Madrid, Spain, 2007
Postdoctoral Fellow: Trudeau Institute, Saranac Lake, NY, 2008
Postdoctoral Fellow: University of Rochester, NY, 2008-2012.

 

Research Interests

The focus of the research in my laboratory is to study the cellular interactions, the environmental cues and the molecular mechanisms that control the differential capacity of distinct populations of dendritic cells (DCs) to regulate effector, memory T cell responses and T follicular helper (Tfh) cell differentiation in different models of infection and autoimmune disease. In addition, we are studying the role of Tfh cells in Systemic Lupus Erythematosus 
(SLE or Lupus) and Rheumatoid arthritis (RA). We found that IL-2 availability is a critical factor that controls Tfh development in vivo and that exogenous IL-2 administration prevents aberrant accumulation of Tfh and GC B cell in lupus-prone mice. We are now exploring the potential therapeutic use of IL-2 in SLE and RA.

 

Selected Publications


Ballesteros-Tato, A.
2014. Beyond regulatory T cells: the potential role for Interleukin-2 (IL-2) to prevent T follicular helper (Tfh) cell responses and treat autoimmune diseases. Immunotherapy. 6(11):1207-20. (2014). PMID: 25496335 PMCID: PMC4289615


Leon, B., Bradley, J.E., Lund, F.E., Randall, T.D. & Ballesteros-Tato, A. 2014. FoxP3+ regulatory T cells promote influenza-specific Tfh responses by controlling IL-2 availability. Nature communications 5, 3495 PMID: 24633065 PMCID: PMC4013682


Ballesteros-Tato, A.
, Leon, B., Lee, B.O., Lund, F.E. & Randall, T.D. 2014. Epitope-specific regulation of memory programming by differential duration of antigen presentation to influenza-specific CD8(+) T cells. Immunity 41, 127-140. PMID: 25035957 PMCID: PMC4233138


Ballesteros-Tato, A.
, Leon, B., Lund, F.E. & Randall, T.D. CD4+ T helper cells use CD154-CD40 interactions to counteract T reg cell-mediated suppression of CD8+ T cell responses to influenza. 2013 The Journal of Experimental Medicine 210, 1591-1601. PMID: 23835849 PMCID: PMC3727323


Ballesteros-Tato, A, 
 León, B, Graf, BA, Moquin, A, Adams, PS, Lund, FE, Randal, TD. 2012 Interleukin-2 Inhibits Germinal Center Formation by Limiting T Follicular Helper Cell Differentiation.  Immunity. 36: 847-856. PMID:22464171


Leon, B, A Ballesteros-Tato, TD Randall and FE Lund. 2012.Regulation of T(H)2 development by CXCR5+ dendritic cells and lymphotoxin-expressing B cells.Nat Immunol. 13:681-690. PMID:22634865 PMCID:PMC3548431

 

Leon B, Ballesteros-Tato A, Misra RS, Wojciechowski W, Lund FE. 2012. Unraveling effector functions of B cells during infection: the hidden world beyond antibody production. Infect Disord Drug Targets. 12:213-221 PMID:22394173


Ballesteros-Tato
A, Randall TD. 2011. Memory: the incomplete unhappening of differentiation.  Immunity. 35:496-498 PMID:22035843


Ballesteros-Tato, A
, B León, FE. Lund and TD. Randall. 2010. Temporal changes in dendritic cell subsets, cross-priming and costimulation via CD70 control CD8+ T cells responses to influenza. Nat. Immunol. 11:216-224. PMID:20098442 PMCID:PMC2822886

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