Laurence A. Bradley, PhD

BradleyProfessor of Medicine


Shelby Building Room 177A
1825 University Blulevard

Telephone:(205) 934-8550
Fax:(205) 934-1564
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.


BA (Psychology), Vanderbilt University, 1971
PhD (Clinical Psychology), Vanderbilt University, 1975
Clinical Internship, Duke University Medical Center, 1975-1976


Research Description

Dr. Bradley's research focuses on the interactions among biological and psychosocial factors associated with abnormal pain sensitivity in persons with osteoarthritis (OA) of the knee, and other chronic painful disorders. Several studies are ongoing:(1) In collaboration with investigators from the University of Florida, the project goal is to characterize ethnic differences in experimental pain sensitivity, endogenous pain inhibition, clinical pain, and pain-related disability in older African-Americans and non-Hispanic whites with and without knee OA and determine whether these measures of pain sensitivity/pain inhibition along with biological, psychological, and socio-cultural variables mediate ethnic group differences in clinical pain and pain-related disability; (2) a related project examines the extent to which differences in pain responses between African-American and white patients with knee OA are mediated by group differences in neurosteroid hormones (3) In collaboration with investigators from the UAB Division of Preventive Medicine, the project goal is to test the efficacy of a cognitive-behavioral intervention, delivered by trained community health workers, in helping persons in rural Alabama with knee OA and diabetes to better manage their pain; and (4) In collaboration with colleagues in the     Multicenter Osteoarthritis Trial (MOST), the project goal is to examine alterations in pain sensitivity using standardized, quantifiable sensory testing to better understand the neurological mechanisms that sustain or magnify painful knee OA symptoms as well as the contribution of pain to functional loss and the long term trajectory of this chronic disease. Future projects include an examination of the relationship between polysomnography measures of sleep and experimental as well as clinical pain  to better understand the biological, psychological, and socio-cultural variables that mediate ethnic group differences in both sleep and pain.

Selected Publications

Goodin BR, Pham Q, Glover T, King C, Sibille KT, Cruz-Almeida Y, Staud R, Redden D, Bradley LA, Fillingim R. Perceived racial discrimination, but not mistrust of medical researchers, predicts the heat pain tolerance of African Americans with symptomatic knee osteoarthritis. Health Psychology, in press, 2013

Goodin BR, Glover TL, Sotolongo A, King CD, Sibille KT, Herbert MS, Cruz-Almeida Y, Sanden SH, Staud R, Redden DT, Bradley LA, Fillingim RB. 2013. The association of greater dispositional optimism with less endogenous pain facilitation is indirectly transmitted through lower levels of pain catastrophizing. J Pain. 14(2):126-35.PMID:23218934

Glover TL, Goodin BR, Horgas AL, Kindler LL, King CD, Sibille KT, Peloquin CA, Riley JL 3rd, Staud R, Bradley LA, Fillingim RB. 2012. Vitamin D, race, and experimental pain sensitivity in older adults with knee osteoarthritis. Arthritis Rheum. 64(12):3926-35. PMID:23135697 PMCID:PMC3510313

Sibille KT, Langaee T, Burkley B, Gong Y, Glover TL, King C, Riley JL 3rd, Leeuwenburgh C, Staud R,  Bradley LA, Fillingim RB. 2012. Chronic pain, perceived stress, and cellular aging: an exploratory study. Mol Pain  8: 12. PMID: 22325162.

Wise BL, Felson DT, Clancy M, Niu J, Neogi T, Lane NE, Hietpas J, Curtis JR, Bradley LA, Torner JC, Zhang Y. 2011. Consistency of Knee Pain and Risk of Knee Replacement: The Multicenter Osteoarthritis Study. J Rheumatol. 38:1390 - 1395  PMID: 21498481

Mease PJ, Spaeth M, Clauw DJ, Arnold LM, Bradley LA, Jon Russell I, Kajdasz DK, Walker DJ, Chappell AS. 2011. Estimation of minimum clinically important difference for pain in fibromyalgia. Arthritis Care Res (Hoboken).  63: 821 - 826 PMID: 21312349

Keefe FJ, Shelby RA, Somers TJ, Varia I, Blazing M, Waters SJ, McKee D, Silva S, She L, Blumenthal JA, O'Connor J, Knowles V, Johnson P, Bradley L. 2011. Effects of coping skills training and sertraline in patients with non-cardiac chest pain: a randomized controlled study. Pain 152: 730-741. PMID: 21324590

Marangell LB, Clauw DJ, Choy E, Wang F, Shoemaker S, Bradley L, Mease P, Wohlreich MM. 2010. Comparative pain and mood effects in patients with comorbid fibromyalgia and major depressive disorder: Secondary analyses of four pooled randomized controlled trials of duloxetine. Pain 152: 31-37 PMID: 20598442

Bradley LA
, Bennett R, Russell IJ, Wohlreich MM, Chappell AS, Wang F, D'Souza DN, Moldofsky H. 2010 Effect of duloxetine in patients with fibromyalgia: tiredness subgroups. Arthritis Res Ther. 12:R141. PMID: 20630058

Bradley LA, Wohlreich MM, Wang F, Gaynor PJ, Robinson MJ, D'Souza DN, Mease PJ. 2010. Pain response profile of patients with fibromyalgia treated with duloxetine. Clin J Pain. 26(6):498-504.PMID: 20551724

Neogi T, Felson D, Niu J, Nevitt M, Lewis CE, Aliabadi P, Sack B, Torner J, Bradley LA, Zhang, Y. 2009. Association between radiographic features of knee osteoarthritis and pain: results from two cohort studies. BMJ 339: b.2844 PMID: 19700505


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