Hughes, Laura B., MD, MSPH

laura_hughesAssociate Professor of Medicine
Director, Rheumatology Fellowship Training Program


Address: 
 

Shelby Bldg, Room 178G
1825 University Blvd.
35294-2182

Telephone: (205) 934-7995
Fax:(205) 996-6734
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

 
Education

 
BS (Zoology), Auburn University, Auburn, Alabama, 1991, cum laude
MD, University of Alabama at Birmingham, Birmingham, Alabama, 1996, with Scholastic Excellence
Internship and Residency (Internal Medicine), Carraway Methodist Medical Center, Birmingham, Alabama, 1996-1999

Chief Resident (Internal Medicine), Carraway Methodist Medical Center, Birmingham, Alabama, 1999-2000
Clinical Fellow (Internal Medicine), Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama , 2001-2003
MSPH (Clinical Trials/Biostatistics), University of Alabama at Birmingham, Birmingham, Alabama, 2001-2003


Research Interests:


Dr. Hughes’ research interest is in identifying pharmacogenetic markers for treatment response and toxicity in subjects with rheumatoid arthritis. She has also investigated genetic markers for susceptibility and severity in African-American subjects with rheumatoid arthritis. Her research interests have recently expanded to include analysis of genetic markers in inflammatory and adipokine genes for association with osteoarthritis.

 

Selected Publications

 

Tamhane A, McGwin G Jr, Redden DT, Hughes LB, Brown EE, Westfall AO, Reynolds RJ, Conn DL, Jonas BL, Smith EA, Brasington RD, Moreland LW, Bridges SL Jr, Callahan LF. 2013. Complementary and alternative medicine use in african-americans with rheumatoid arthritis. Arthritis Care Res (Hoboken). 2013 Aug 27. doi: 10.1002/acr.22148. [Epub ahead of print] PMID:23983105

 

Reynolds RJ, Cui X, Vaughan LK, Redden DT, Causey Z, Perkins E, Shah T, Hughes LB; CLEAR Investigators, Damle A, Kern M, Gregersen PK, Johnson MR, Bridges SL Jr. 2013. Gene expression patterns in peripheral blood cells associated with radiographic severity in African Americans with early rheumatoid arthritis. Rheumatol Int. 33(1):129-37. PMID:22238028 PMCID:PMC3769702

 

Perkins EA, Landis D, Causey ZL, Edberg Y, Reynolds RJ, Hughes LB, Gregersen PK, Kimberly RP, Edberg JC, Bridges SL Jr; Consortium for the Longitudinal Evaluation of African Americans with Early Rheumatoid Arthritis Investigators. 2012. Association of single-nucleotide polymorphisms in CCR6, TAGAP, and TNFAIP3 with rheumatoid arthritis in African Americans. Arthritis Rheum. 64(5):1355-8. PMID:22127930 Free PMC Article

 

Guermazi A, Roemer FW, Hayashi D, Crema MD, Niu J, Zhang Y, Marra MD, Katur A, Lynch JA, El-Khoury GY, Baker K, Hughes LB, Nevitt MC, Felson DT. 2011. Extended report: assessment of synovitis with contrast-enhanced MRI using a whole-joint semiquantitative scoring system in people with, or at high risk of, knee osteoarthritis: the MOST study. Ann Rheum Dis. 70(5):805-11.  PMID: 21187293

 

Hughes LB, Reynolds RJ, Brown EE, Kelley JM, Thomson B, Conn DL, Jonas BL, Westfall AO, Padilla MA, Callahan LF, Smith EA, Brasington RD, Edberg JC, Kimberly RP, Moreland LW, Plenge RM, Bridges SL Jr. 2010. Most common single-nucleotide polymorphisms associated with rheumatoid arthritis in persons of European ancestry confer risk of rheumatoid arthritis in African Americans. Arthritis Rheum. 62(12):3547-53. PMID: 21120996

 

Hughes LB, Reynolds RJ, Brown EE, Kelley JM, Thomson B, Conn DL, Jonas BL, Westfall AO, Padilla MA, Callahan LF, Smith EA, Brasington RD Jr, Edberg JC, Kimberly RP, Moreland LW, Plenge RM, Bridges SL Jr. 2010. Most common SNPs associated with rheumatoid arthritis in subjects of European ancestry confer risk of rheumatoid arthritis in African-Americans. Arthritis Rheum.  [Epub ahead of print] PMID: 20973039

 

Danila MI, Hughes LB, Brown EE, Morgan SL, Baggott JE, Arnett DK, Bridges SL Jr. 2010. Measurement of erythrocyte methotrexate polyglutamate levels: ready for clinical use in rheumatoid arthritis? Curr Rheumatol Rep. 12(5):342-7. PMID: 20665136

 

Bridges SL Jr, Causey ZL, Burgos PI, Huynh BQ, Hughes LB, Danila MI, van Everdingen A, Ledbetter S, Conn DL, Tamhane A, Westfall AO, Jonas BL, Callahan LF, Smith EA, Brasington R, Moreland LW, Alarcón GS, van der Heijde DM.. 2010. Radiographic severity of rheumatoid arthritis in African Americans: results from a multicenter observational study. Arthritis Care Res (Hoboken). 62(5):624-31. PMID: 20461784

 

Burgos PI, Causey ZL, Tamhane A, Kelley JM, Brown EE, Hughes LB, Danila MI, van Everdingen A, Conn DL, Jonas BL, Callahan LF, Smith EA, Brasington RD Jr, Moreland LW, van der Heijde DM, Alarcón GS, Bridges SL Jr. 2010. Association of IL4R single-nucleotide polymorphisms with rheumatoid nodules in African Americans with rheumatoid arthritis. Arthritis Res Ther. 12(3):R75. PMID: 20444266

 

Cui J, Saevarsdottir S, Thomson B, Padyukov L, van der Helm-Van Mil AH, Nititham J, Hughes LB, de Vries N, Raychaudhuri S, Alfredsson L, Askling J, Wedrén S, Ding B, Guiducci C, Wolbink GJ, Crusius JB, van der Horst-Bruinsma IE, Herenius M, Weinblatt ME, Shadick NA, Worthington J, Batliwalla F, Kern M, Morgan AW, Wilson AG, Isaacs JD, Hyrich K, Seldin MF, Moreland LW, Behrens TW, Allaart CF, Criswell LA, Huizinga TW, Tak PP, Bridges SL Jr, Toes RE, Barton A, Klareskog L, Gregersen PK, Karlson EW, Plenge RM; Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate. 2010. Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy. Arthritis Rheum. 62(7):1849-1861. PMID: 20309874

 

Kelley JM, Hughes LB, Malik A, Danila MI, Edberg Y, Alarcón GS, Conn DL, Jonas BL, Callahan LF, Smith EA, Brasington RD, Edberg JC, Kimberly RP, Moreland LW, Bridges SL. 2010. Genetic variants of STAT4 associated with rheumatoid arthritis in persons of Asian and European ancestry do not replicate in African Americans. Ann Rheum Dis. 69(4):625-6.PMID: 20237121

 

Roemer FW, Zhang Y, Niu J, Lynch JA, Crema MD, Marra MD, Nevitt MC, Felson DT, Hughes LB, El-Khoury GY, Englund M, Guermazi A; Multicenter Osteoarthritis Study Investigators. 2009. Tibiofemoral joint osteoarthritis: risk factors for MR-depicted fast cartilage loss over a 30-month period in the multicenter osteoarthritis study. Radiology. 252(3):772-80. PMID: 19635831

 

Danila MI, Hughes LB, Bridges SL. 2008. Pharmacogenetics of etanercept in rheumatoid arthritis. Pharmacogenomics. 9(8):1011-5. PMID: 18681777

 

Bridges SL Jr, Kelley JM, Hughes LB. 2008. The HLA-DRB1 shared epitope in Caucasians with rheumatoid arthritis: a lesson learned from tic-tac-toe. Arthritis Rheum. 58(5):1211-5. PMID: 18438835

 

Hughes LB, Morrison D, Kelley JM, Padilla MA, Vaughan LK, Westfall AO, Dwivedi H, Mikuls TR, Holers VM, Parrish LA, Alarcón GS, Conn DL, Jonas BL, Callahan LF, Smith EA, Gilkeson GS, Howard G, Moreland LW, Patterson N, Reich D, Bridges SL Jr. 2008. The HLA-DRB1 shared epitope is associated with susceptibility to rheumatoid arthritis in African Americans through European genetic admixture. Arthritis Rheum. 58(2):349-58. PMID: 18240241

 

Kelley JM, Hughes LB, Bridges SL Jr. 2008. Does gamma-aminobutyric acid (GABA) influence the development of chronic inflammation in rheumatoid arthritis? J Neuroinflammation. 2008 5:1. PMID: 18171484

 

Hughes LB, Beasley TM, Patel H, Tiwari HK, Morgan SL, Baggott JE, Saag KG, McNicholl J, Moreland LW, Alarcón GS, Bridges SL Jr. 2006. Racial or ethnic differences in allele frequencies of single-nucleotide polymorphisms in the methylenetetrahydrofolate reductase gene and their influence on response to methotrexate in rheumatoid arthritis. Ann Rheum Dis. 65(9):1213-8. PMID: 16439441

 

Hughes LB, Moreland LW, Bridges SL Jr. 2002. Genetic influences on rheumatoid arthritis in African Americans. Immunol Res. 26(1-3):15-26. PMID: 12403341

 

&Hughes LB, Bridges SL Jr. 2002. Polyarteritis nodosa and microscopic polyangiitis: etiologic and diagnostic considerations. Curr Rheumatol Rep. 4(1):75-82. PMID: 11798986

 

 

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