Professor of Medicine
Shelby Building, Room 305
1825 University Boulevard
BSc (Zoology), Madras University, India
MSc (Microbiology), Idaho State University
PhD (Microbiology-Immunology), Southern Illinois University
Postdoctoral Studies, Loyola University in Chicago, Stritch School of Medicine, with Dr. Katherine Knight
Dr. Raman’s research interrogates molecular and cellular mechanisms driving the immunopathogenesis of autoimmune diseases with a special emphasis on multiple sclerosis (MS) and rheumatoid arthritis (RA). Within this context, the research interest of the Raman laboratory is the study of activation and differentiation of effector T cells and B cells in the pathogenesis of these autoimmune disease. Current investigations involve human samples from patients with MS or RA as well mouse models to study these diseases. The major areas of investigation are:
(1) The mechanisms modulating the activation of T-cells and differentiation to pathogenic (Th1, Th17 and ThIFNγIL-17 –dual producers), regulatory (nTreg, iTreg) Th subsets and cells of the innate immune system (dendritic cells, macrophages and microglia). Within this area of study, the Raman laboratory has a special interest in type 1 and type 2 interferons, and TGFβ family proteins in the pathogenesis of MS, RA and the mouse model, experimental autoimmune encephalomyelitis (EAE).
(2) Molecular mechanisms by which CK2 and GSK3 modulates effector and regulatory cells in the pathogenesis of autoimmunity.
(3) Role of CD5 in T cell and B-1a B cell development, differentiation, immunity and pathogenesis – the laboratory focuses on B-1a B cell-dependent T-independent antibody responses, T-dependent antibody responses, autoreactive B-cell generation and persistence and regulatory B-cells. For these studies, the Raman laboratory has generated unique knock-in CD5 mutant mice in which signaling domains associated with CD5-inhibitory activity (ITIM) and CD5-CK2 activation have been ablated.
(4) TGFβR3/betaglycan dependent regulation of adaptive immune effector cells in the pathogenesis of autoimmune diseases
Click here for a more complete list of publications. Below are a few selected papers
Naves R, Singh SP, Cashman KS, Rowse AL, Axtell RC, Steinman L, Mountz JD, Steele C, De Sarno P, Raman C. 2013. The Interdependent, Overlapping, and Differential Roles of Type I and II IFNs in the Pathogenesis of Experimental Autoimmune Encephalomyelitis. J Immunol. 191(6):2967-77. PMID:23960239
Harms AS, Cao S, Rowse AL, Thome AD, Li X, Mangieri LR, Cron RQ, Shacka JJ, Raman C, Standaert DG. 2013. MHCII is required for α-synuclein-induced activation of microglia, CD4 T cell proliferation, and dopaminergic neurodegeneration. J Neurosci. 33(23):9592-600. PMID:23739956
Roa NS, Ordoñez-Rueda D, Chávez-Rios JR, Raman C, García-Zepeda EA, Lozano F, Soldevila G. 2013. The carboxy-terminal region of CD5 is required for c-CBL mediated TCR signaling downmodulation in thymocytes. Biochem Biophys Res Commun. 432(1):52-9. PMID:23376399
Rowse AL, Naves R, Cashman KS, McGuire DJ, Mbana T, Raman C, De Sarno P. 2012. Lithium controls central nervous system autoimmunity through modulation of IFN-γ signaling. PLoS One. 7(12):e52658. PMID:23285134 Free PMC Article
Aleman-Muench GR, Mendoza V, Stenvers K, Garcia-Zepeda EA, Lopez-Casillas F, Raman C, Soldevila G. 2012. Betaglycan (TβRIII) is expressed in the thymus and regulates T cell development by protecting thymocytes from apoptosis. PLoS One. 2012;7(8):e44217. PMID:22952931 Free PMC Article
Sestero CM, McGuire DJ, De Sarno P, Brantley EC, Soldevila G, Axtell RC, Raman C. 2012. CD5-dependent CK2 activation pathway regulates threshold for T cell anergy. J Immunol. 189(6):2918-30. PMID:22904299 Free PMC Article
Axtell RC, Raman C. 2012. Janus-like effects of type I interferon in autoimmune diseases. Immunol Rev. 248(1):23-35. PMID:22725952 Free PMC Article
Qin H, Yeh WI, De Sarno P, Holdbrooks AT, Liu Y, Muldowney MT, Reynolds SL, Yanagisawa LL, Fox TH 3rd, Park K, Harrington LE, Raman C, Benveniste EN. 2012. Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation. Proc Natl Acad Sci U S A. 109(13):5004-9. PMID:22411837 Free PMC Article
Axtell RC, Raman C, Steinman L. 2013. Type I interferons: beneficial in Th1 and detrimental in Th17 autoimmunity. Clin Rev Allergy Immunol. 44(2):114-20. PMID:22231516
Gibson AW, Li X, Wu J, Baskin JG, Raman C, Edberg JC, Kimberly RP. 2012. Serine phosphorylation of FcγRI cytoplasmic domain directs lipid raft localization and interaction with protein 4.1G. J Leukoc Biol. 91(1):97-103. PMID:22003208 Free PMC Article
Katiyar SK, Raman C. 2011. Green tea: a new option for the prevention or control of osteoarthritis. Arthritis Res Ther. 13(4):121. PMID:21861859 Free PMC Article
Lutz J, Heideman MR, Roth E, van den Berk P, Müller W, Raman C, Wabl M, Jacobs H, Jäck HM 2011. Pro-B cells sense productive immunoglobulin heavy chain rearrangement irrespective of polypeptide production. Proc Natl Acad Sci U S A.108(26):10644-9. PMID:21670279
Tabbekh M, Franciszkiewicz K, Haouas H, Lécluse Y, Benihoud K, Raman C, Mami-Chouaib F. 2011. Rescue of tumor-infiltrating lymphocytes from activation-induced cell death enhances the antitumor CTL response in CD5-deficient mice. J Immunol. 187(1):102-9. PMID:21622855
Axtell RC, Raman C, Steinman L. 2011. Interferon-β exacerbates Th17-mediated inflammatory disease. Trends Immunol. 2011 Apr 29. [Epub ahead of print] PMID: 21530402
Soldevila G, Raman C, Lozano F. 2011. The immunomodulatory properties of the CD5 lymphocyte receptor in health and disease. Curr Opin Immunol. 2011 Apr 7. [Epub ahead of print] PMID: 21482089
Axtell RC, de Jong BA, Boniface K, van der Voort LF, Bhat R, De Sarno P, Naves R, Han M, Zhong F, Castellanos JG, Mair R, Christakos A, Kolkowitz I, Katz L, Killestein J, Polman CH, de Waal Malefyt R, Steinman L, Raman C. 2010. T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis. Nature Med. 16(4):406-12 PMID: 20348925
Gagnon J, Chen XL, Forand-Boulerice M, Leblanc C, Raman C, Ramanathan S, Ilangumaran S. 2010. Increased antigen responsiveness of naive CD8 T cells exposed to IL-7 and IL-21 is associated with decreased CD5 expression. Immunol Cell Biol. 88(4):451-60. PMID: 20065997
Wang JH, Li J, Wu Q, Yang P, Pawar RD, Xie S, Timares L, Raman C, Chaplin DD, Lu L, Mountz JD, Hsu HC. 2010. Marginal zone precursor B cells as cellular agents for type I IFN-promoted antigen transport in autoimmunity. J Immunol. 184(1):442-51.PMID: 19949066
Ordoñez-Rueda D, Lozano F, Sarukhan A, Raman C, Garcia-Zepeda EA, Soldevila G. 2010. Increased numbers of thymic and peripheral CD4+ CD25+Foxp3+ cells in the absence of CD5 signaling. Eur. J Immunol. 39(8):2233-47.PMID: 19609976
Dasu T, Qualls JE, Tuna H, Raman C, Cohen DA, Bondada S. CD5 plays an inhibitory role in the suppressive function of murine CD4(+) CD25(+) T(reg) cells. Immunol Lett. 2008 Aug 15;119(1-2):103-13. Epub 2008 Jun 23. PMID: 18573278
De Sarno P, Axtell RC, Raman C, Roth KA, Alessi DR, Jope RS. Lithium prevents and ameliorates experimental autoimmune encephalomyelitis. J Immunol. 2008 Jul 1;181(1):338-45. PMID: 18566399
Axtell RC, Xu L, Barnum SR, Raman C. CD5-CK2 binding/activation-deficient mice are resistant to experimental autoimmune encephalomyelitis: protection is associated with diminished populations of IL-17-expressing T cells in the central nervous system. J Immunol. 2006 Dec 15;177(12):8542-9. PMID: 17142752.
Szalai AJ, Hu X, Raman C, Barnum SR. Requirement of the Fc receptor common gamma-chain for gamma delta T cell-mediated promotion of murine experimental autoimmune encephalomyelitis. Eur J Immunol. 2005 Dec;35(12):3487-92. PMID: 16278814.
Bullard DC, Hu X, Schoeb TR, Axtell RC, Raman C, Barnum SR. Critical requirement of CD11b (Mac-1) on T cells and accessory cells for development of experimental autoimmune encephalomyelitis. J Immunol. 2005 Nov 15;175(10):6327-33. PMID: 16272284.
Axtell RC, Webb MS, Barnum SR, Raman C. Cutting edge: critical role for CD5 in experimental autoimmune encephalomyelitis: inhibition of engagement reverses disease in mice. J Immunol. 2004 Sep 1;173(5):2928-32. PMID: 15322150.
Kevil CG, Hicks MJ, He X, Zhang J, Ballantyne CM, Raman C, Schoeb TR, Bullard DC. Loss of LFA-1, but not Mac-1, protects MRL/MpJ-Fas(lpr) mice from autoimmune disease. Am J Pathol. 2004 Aug;165(2):609-16. PMID: 15277234
John B, Herrin BR, Raman C, Wang YN, Bobbitt KR, Brody BA, Justement LB. The B cell coreceptor CD22 associates with AP50, a clathrin-coated pit adapter protein, via tyrosine-dependent interaction. J Immunol. 2003 Apr 1;170(7):3534-43. PMID: 12646615.
Raman C. CD5, an important regulator of lymphocyte selection and immune tolerance. Immunol Res. 2002;26(1-3):255-63. PMID: 12403363.
Lu X, Axtell RC, Collawn JF, Gibson A, Justement LB, Raman C. AP2 adaptor complex-dependent internalization of CD5: differential regulation in T and B cells. J Immunol. 2002 Jun 1;168(11):5612-20. PMID: 12023358.