Schroeder 2012 2John R Irby Research Scholar

Professor of Medicine, Microbiology, and Genetics

Division Clinical Immunology & Rheumatology

Director, UAB Program in Immunology
Director, Immunologic Diseases & Basic Immunology Training Program

 

Address:

Shelby Building, Room 405
1825 University Boulevard, 35294-2182

Telephone: 205-934-1522
Email: hschroeder@uabmc.edu

 

Associate: Dr. Ada Elgavish
Shelby Building, Room 414
1825 University Blvd.
Birmingham, AL35294-2182
Telephone:205-934-6547
Email: aelgavis@uab.edu

 

Education

BS (Chemistry), Texas A&M University, College Station, TX
MD, Baylor College of Medicine, Houston, TX
PhD (Cell Biology), Baylor College of Medicine, Houston, TX

 

Research Interests

B cell and repertoire development.   Although at first glance the power of the mechanisms used to diversify the B- and T-cell antigen receptors appear to generate repertoires of random diversity, closer examination reveals striking constraints that are preserved across evolution.  The implication is that violation of these constraint programs could lead to immune dysfunction, and thus to disease.  My group has used Cre-loxP gene targeting to generate mice wherein the DH locus has been altered for force expression of polyclonal antibody repertoires that lie outside normal constraints.  In these mice, B cell numbers are reduced, responses to T-independent antigens decline in a co-dominant manner, and responses to T-dependent antigens and autoantigens are affected in a dominant manner.  The mechanisms that underlie these alterations and the contribution of a failure to properly regulate the repertoire are a major focus of the laboratory. 

Genetics of primary immune deficiency diseases
. A second focus in the laboratory is the use of classic reverse genetics techniques to study human immune deficiency disorders.

 

Publications

Click here for a more complete list of publications in PubMed. Below are a few selected papers.


Wang Y, Hwangpo T, Martin MP, Vince N, Qi Y, Reynolds RJ IV, Absher D, Gao X, Ballinger CA, Burrows PD, Atkinson TP, Brown EE, Elgavish A, Liu CR, Carrington M, Schroeder HW Jr. 2016. Killer cell immunoglobulin-like receptors are associated with Common Variable Immune Deficiency (CVID) pathogenesis. J Allergy Clin Immunol. 138(5):1495-149.  PMC5104182.


Khass M, Blackburn T, Burrows PD, Walter MR, Capriotti E, Schroeder HW Jr. 2016. VpreB serves as an invariant surrogate antigen for selecting immunoglobulin antigen binding sites. Sci Immunol 1 (1): pii:aaf6628. PMC5315267


Silva-Sanchez A, Liu C, Kapoor P, Vale AM, Khass M, Ivanov II, Zhuang Y, Schoeb TR, Burrows PD, Schroeder HW Jr. 2015. Violation of a conserved Ig DH sequence preference promotes production of dsDNA-specific IgG antibodies. PLoS One. 10(2):e0118171.  PMC4338297.


Vale AM, Kapoor P, Skibinski G, Elgavish A, Mahmoud T, Zemlin C, Zemlin M, Burrows PD, Nobrega A, Kearney JF, Briles DE, Schroeder HW Jr. 2013. The link between antibodies to OxLDL and natural protection against pneumococci depends on DH gene conservation. J Exp Med 210(5) 875-890. PMC3646500.

 

SOM Epilogue Menu