Professor of Medicine

Address:  

UAB Highlands, Room 510
35294-4563

Telephone: (205) 930-8347
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Education

BA, Vanderbilt University, 1967-1971
MD,University of Florida, Gainesville, FL, 1971-1975
Residence, University of Alabama at Birmingham, 1975-1978
Fellow-Associate Instructor, Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham,1978-1980

Research and Clinical Description

 
Dr. Spalding was on the UAB faculty for seven years, attaining the position of Associate Professor of Medicine, Assistant Professor of Microbiology and Deputy Director of the Multipurpose Arthritis Center. He also served as Acting Division Director for 9 months while Dr William Koopman was on sabbatical. After leaving in 1986 he practiced with Watson Clinic in Lakeland, FL for 12 years. Subsequently, he practiced for 10 years with Melbourne Internal Medicine Associates in Melbourne,FL. He returned to a full time UAB faculty position in August 2008. Dr. Spalding has authored and co-authored more than 40 articles, abstracts, book chapters, and reviews concerning basic immunology and rheumatology. He is a Fellow in the American College of Physicians and American College of Rheumatology and has served on two committees of the American College of Rheumatology. Dr. Spalding is a recipient of the Arthritis Foundation Investigator Award and has been listed in “Best Doctors in America” since 1999.

Selected Publications

Everson MP, Spalding DM, Koopman WJ. 1989.Exquisite sensitivity of dendritic cells to ultraviolet radiation and temperature changes. Transplantation. 48(4):666-71. PMID: 2799921

Saleh F, Spalding DM, Griffin JA. 1989. Pre-pre-B cells containing only cytoplasmic B220 can be induced by dendritic cells and T cells to differentiate in vitro. Cell Immunol. 123(1):44-59. PMID: 2476244

Griffin JA, Spalding DM. 1989. Many different levels of maturation and commitment are present in nontransformed cells identified serologically as pre-B cells. Cell Immunol. 119(2):393-401. PMID: 2467750

Everson MP, Spalding DM, Koopman WJ. 1989. Enhancement of IL-2-induced T cell proliferation by a novel factor(s) present in murine spleen dendritic cell-T cell culture supernatants. J Immunol. 142(4):1183-94. PMID: 2644351

Griffin JA, Spalding DM. 1988. VH gene expression by nontransformed pre-B cells upon differentiation in vitro. J Immunol. 140(11):3982-7. PMID: 3131423

Casebolt DB, Spalding DM, Schoeb TR, Lindsey JR. 1987. Suppression of immune response induction in Peyer's patch lymphoid cells from mice infected with mouse hepatitis virus. Cell Immunol. 109(1):97-103. PMID: 2820590

Spalding DM, Griffin JA. 1987. A novel pre-B cell precursor: phenotypic characterization and differentiation induction by dendritic cell-T cell mixtures. Adv Exp Med Biol. 216A:197-208. PMID: 3500574

Oh SJ, Herrera GA, Spalding DM. 1986. Eosinophilic vasculitic neuropathy in the Churg-Strauss syndrome. Arthritis Rheum. 29(9):1173-5. PMID: 2875720

Spalding, D.M. and Griffin, J.A. 1986. Different pathways of differentiation of pre-B cell lines are induced by dendritic cells and T cells from different lymphoid tissues. Cell 44: 507-15. PMID: 2417730

Spalding DM, Williamson SI, Koopman WJ, McGhee JR. 1984. Preferential induction of polyclonal IgA secretion by murine Peyer's patch dendritic cell-T cell mixtures. J Exp Med. 160(3):941-6. PMID: 6332171

Spalding DM, Koopman WJ, Eldridge JH, McGhee JR, Steinman RM. 1983. Accessory cells in murine Peyer's patch. I. Identification and enrichment of a functional dendritic cell. J Exp Med. 157(5):1646-59. PMID: 6343548