Volanakis, John E., MD

VolanakisProfessor Emeritus of Medicine


Shelby Bldg., Room 411
1825 University Blvd.

Telephone: (205) 934-5235
Fax: (205) 934-1477
Email: volanaki@uab.edu


Research Interests

Dr. Volanakis's research focuses on the structure and function of complement in health and disease.


Selected Publications

Krishnan V, Ponnuraj K, Xu Y, Macon K, Volanakis JE, Narayana SV. 2009. The crystal structure of cobra venom factor, a cofactor for C3- and C5-convertase CVFBb. Structure. 17(4):611-9. PMID: 19368894

Krishnan V, Xu Y, Macon K, Volanakis JE, Narayana SV. 2009. The structure of C2b, a fragment of complement component C2 produced during C3 convertase formation. Acta Crystallogr D Biol Crystallogr. 65(Pt 3):266-74. PMID: 19237749

Krishnan V, Xu Y, Macon K, Volanakis JE, Narayana SV. 2007. The crystal structure of C2a, the catalytic fragment of classical pathway C3 and C5 convertase of human complement. J Mol Biol. 367(1):224-33. PMID: 17234210

Abdul Ajees A, Gunasekaran K, Volanakis JE, Narayana SV, Kotwal GJ, Murthy HM. 2006. The structure of complement C3b provides insights into complement activation and regulation. Nature. 444(7116):221-5. PMID: 17051152

Ligoudistianou C, Xu Y, Garnier G, Circolo A, Volanakis JE. 2005. A novel human complement-related protein, C1r-like protease (C1r-LP), specifically cleaves pro-C1s. Biochem J. 387(Pt 1):165-73. PMID: 15527420

Ponnuraj K, Xu Y, Macon K, Moore D, Volanakis JE, Narayana SV. 2004. Structural analysis of engineered Bb fragment of complement factor B: insights into the activation mechanism of the alternative pathway C3-convertase. Mol Cell. 14(1):17-28. PMID: 15068800

Szalai AJ, Weaver CT, McCrory MA, van Ginkel FW, Reiman RM, Kearney JF, Marion TN, Volanakis JE. 2003. Delayed lupus onset in (NZB x NZW)F1 mice expressing a human C-reactive protein transgene. Arthritis Rheum. 48(6):1602-11. PMID: 12794828

Circolo A, Garnier G, Volanakis JE. 2003. A novel murine complement-related gene encoding a C1r-like serum protein. Mol Immunol. 39(14):899-906. PMID: 12686506

Garnier G, Circolo A, Xu Y, Volanakis JE. 2003. Complement C1r and C1s genes are duplicated in the mouse: differential expression generates alternative isomorphs in the liver and in the male reproductive system. Biochem J. 371(Pt 2):631-40. PMID: 12513694




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