Lowe, Robert M., MD, PhD

Lowe_2012Instructor, Department of Pediatrics
Division of Pediatric Rheumatology


Address: 
 

Children's Park Place, Suite 210
1601 4th Avenue South
Birmingham, AL 35233-1711

Telephone: 205-638-9438
FAX: (205) 996-9545
Email: rlowe@peds.uab.edu 

 
Education

 
BS (Biology; with Distinction), University of Pennsylvania, 1992
Predoctoral Fellow, National Institutes of Health, 1993
PhD (Cellular & Molecular Biology), University of Washington, 2003
MD, University of Washington, 2004
Intern (Pediatrics), Rainbow Babies and Children's Hospital, Cleveland, OH, 2004-2005
Resident (Pediatrics), Rainbow Babies and Children's Hospital, Cleveland, OH, 2005-2007
Fellow (Pediatric Rheumatology), Rainbow Babies and Children's Hospital, Cleveland, OH, 2007-2010

 
Major Research Interests 

    • Role of epigenetics (DNA methylation, histone acetylation/methylation, and micro RNA expression) in the abnormal overexpression of the CD154 gene (CD40-ligand) in adults and children with lupus.
    • Role of FoxP3 in blocking transcriptional activation of  HIV-LTR in regulatory T cells (Tregs)
    • Gene replacement therapy for X-linked Hyper-IgM Syndrome (CD154 deficiency)



Selected Publications

 
Mullen, C.A., Coale, M.M., Lowe. R., Blaese, R.M. 1994. Tumors expressing the cytosine deaminase suicide gene can be eliminated in vivo with 5]fluorocytosine and induce protective immunity to wild type tumor. Cancer Research 54: 1503-62. PMID: 8137255

 
Mullen CA, Petropoulos D, Lowe RM. 1996. Treatment of microscopic pulmonary metastases with recombinant autologous tumor vaccine expressing interleukin 6 and Escherichia coli cytosine deaminase suicide genes. Cancer Res. 156(6):1361-6. PMID: 8640826

 
Lotfi K, Sund G, Lowe R, Graham J, Landin-Olsson M, Kockum I, Deeb S, Lernmark A. 1997. The beta cell glucokinase promoter variant is an unlikely risk factor for diabetes mellitus. Diabetes Incidence Study in Sweden (DISS).  Diabetologia 40: 959-962. PMID: 9267992

 
Undlien, D. E., Kockum, I., Ronningen, K. S., Lowe, R., Saanjeevi, C. B., Graham, J., Lie, B. A., Akselsen, H. E., Lernmark, A., Thorsby, E. 1999. HLA associations in type 1 diabetes among patients not carrying high-risk DR3-DQ2 or DR4-DQ8 haplotypes. Tissue Antigens 54: 543-51. PMID: 10674967

 
Lowe, R. M., Graham, J., Sund, G., Kockum, I., Landin-Olsson, M., Schaefer, J. B., Torn, C., Lernmark, A., Dahlquist, G. 2000. The length of the CTLA-4 microsatellite (AT)N-repeat affects the risk for type 1 diabetes. Diabetes Incidence in Sweden Study Group. Autoimmunity 32: 173-80. PMID: 11092697

 
Graham, J., Hagopian, W. A., Kockum, I., Li, L. S.; Sanjeevi, C. B., Lowe, R. M., Schaefer, J. B., Zarghami, M., Day, H. L., Landin-Olsson, M., Palmer, J. P., JanerVillanueva, M., Hood, L., Sundkvist, G., Lernmark, A., Breslow, N., Dahlquist, G., Blohme, 2002. Genetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetes. Diabetes 51: 1346-55. PMID: 11978629

 
Singer, N. G, Tomanova-Soltys, I., Lowe, R.M. 2008. Sjogren's syndrome in childhood. Curr Rheumatol Rep 10(2): 147-55. PMID: 18460271

 
Lowe, R.M.and Hashkes, P.J. 2008. Growing pains: A noninflammatory pain syndrome in children. Nature Clin Practice Rheum. 4(10):542-9. PMID: 18762787

 

 

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