Investigators in the UAB Division of Clinical Immunology and Rheumatology garnered research grants and contracts (excluding VA funding) amounting to ~$20.7 million in FY 2009. For details on the research programs of our faculty, please visit the individual webpages under the "Faculty" tab. Selected highlights of our campus-wide, multidisciplinary, or multicenter research programs can be accessed by clicking on the respective links below.
The Comprehensive Arthritis, Musculoskeletal and Autoimmunity Center (CAMAC) is dedicated to generating new knowledge and to applying such to the diagnosis and treatment of patients with arthritis, musculoskeletal and autoimmune diseases. This charge includes integrating and promoting fundamental research with clinical care, developing and applying new diagnostics and therapeutics, educating the public about arthritis, musculoskeletal, and autoimmune diseases, and training future investigators and health care professionals.
The multi-disciplinary Program in Immunology (Harry Schroeder, Jr., MD, PhD, Director and David Chaplin, MD, PhD, Co-director) consists of over 100 UAB Faculty who identify themselves as basic or clinical immunologists and are members of multiple units at UAB. A desire for excellence on the part of the UAB faculty, coupled with the relative youth of the institution, has promoted a collective attitude of interdepartmental cooperation and collegiality.
The NIAMS MCRC (Multidisciplinary Clinical Research Center). Directed by Robert P. Kimberly, MD, Division of Clinical Immunology & Rheumatology is a program designed to foster and promote research related to the causes, diagnosis, treatment, and improved care of patients suffering from arthritis and musculoskeletal diseases (MSD). To this end, highly-rigorous fundamental and clinical research is supported with state-of-the-art methodology with the following mission: (1) To conduct outstanding, innovative research projects drawing on the unique strengths of the AMC and using state-of-the-art tools from statistics, epidemiology, outcomes, health services, and behavioral research; (2) To foster the development of new projects and the development and application of new evaluative, analytic, and translational methods to research in arthritis and MSD; (3) To promote the training of new, and the continuing education of established, clinical investigators in the most current methods of research and evaluation applicable to arthritis and MSD
To complement ongoing research, the RDCC (Rheumatic Diseases Core Center), (NIH/NIAMS 5P30 AR048311) directed by John Mountz, MD, PhD, has a strong obligation to provide access to innovative experimental methodologies. As such, the RDCC supports three scientific cores: (1) Comprehensive Flow Cytometry Core (CFCC) directed by John D. Mountz, MD, PhD; (2) Analytic Imaging and Immunoreagent Core (AIIC) directed by Kent T. Keyser, PhD; and (3) Analytical Genomics and Transgenics Core (AGTC) Facility directed by Robert A. Kesterson, PhD.
CERTS (Center for Education & Research on Therapeutics of Musculoskeletal Disorders). The mission of the UAB CERTS is to evaluate the effectiveness, safety and impact on health related quality of life and to educate practitioners, insurers, policy makers, and the general public about Musculoskeletal Disease (MSD) therapeutics. The director of CERTS is Kenneth Saag, MD, MSc, Professor of Medicine in the Division of Clinical Immunology & Rheumatology.
COERE (Center for Outcomes and Effectiveness Research and Education). The mission of the UAB COERE is to build and maintain a successful program of research targeted at improving the quality and outcomes of health care. COERE is directed by Kenneth Saag, MD, MSc, Professor of Medicine in the Division of Clinical Immunology & Rheumatology.
UAB Center of Research Translation (CORT) (Kenneth G. Saag, MD, MSc, Director; S. Louis Bridges, Jr, MD, PhD, Co-Director; P50AR060772). Gout affects roughly 1-2% of the U.S. population. With the “Graying of America”, the societal burden of gout will likely grow.It is well known is that gout, hyperuricemia, and vascular disease are more common among African Americans than Caucasians, yet little is known about the impact environmental factors have in increasing risk of gout in this minority population. To address these gaps our multi-disciplinary UAB CORT is conducting 3 research projects focused around the theme of "Gout and Hyperuricemia: from Bench to Bedside to Backyard”.
ACIP (Arthritis Clinical Intervention Program). ACIP is a full service clinical trial unit that conducts studies in rheumatology (Phase I-IV). Current studies focus on rheumatoid arthritis (RA), gout, scleroderma, lupus and vasculitis. Jeffrey Curtis, MD, MS, MPH, is the Medical Director of this program.
CLEAR Registry (Consortium for the Longitudinal Evaluation of African-Americans with Early Rheumatoid Arthritis). Supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), CLEAR was established in 2000 to provide a resource for the scientific community to explore genetic and non-genetic factors affecting rheumatoid arthritis (RA) occurrence and outcomes. The long term objective is a database and a repository of 1,000 RA and 500 matched healthy African-American subjects. This consortium is a collaborative effort among five institutions. The UAB site, under the direction of S. Louis Bridges, Jr, MD, PhD, Director, Division of Clinical Immunology & Rheumatology is the coordinating center.
The Mission of the UAB Injury Control Research Center (ICRC) is to help the nation achieve a significant reduction in the rate of injuries and their resulting deaths and disabilities, especially in the southeastern United States. Our mission follows directly from the injury prevention-related goals of Healthy People 2010: to reduce injuries, disabilities and deaths due to unintentional injuries and violence; and, correspondingly, is consistent with the National Center for Injury Prevention and Control’s goal of reducing injuries and their resulting deaths and disabilities. The UAB ICRC is accomplishing its mission through the development of new and improved approaches for preventing injuries and reducing their negative outcomes. Major goals are to: (1) Conduct research that advances our basic understanding of injury; (2) Apply the results of research (both our own and the research of others) to the practice of injury prevention and control; (3) Advocate for the integration of research results into the practice of injury prevention and control; (4) Train future injury researchers and practitioners in relevant, appropriate and state-of-the-art research procedures; and (5) Train future public health professionals in the elements of evidence-informed practice, particularly as it relates to injury prevention and control. P. Russ Fine, PhD, MSPH, is the Director of ICRC.
The theme for the UAB University Transportation Center (UTC) was conceptualized by the Executive Committee after consultation with Dr. Dan Turner, founding Director of the University Transportation Center for Alabama (UTCA). The Advisory Board recommended adoption of the proposed UAB-UTC theme because it was judged to be in support of USDOT's vision of safer, simpler and smarter transportation, the first goal of FTA's strategy plan of safety and security, NHTSA's goal of addressing the most significant traffic and motor vehicle safety issues, and FHWA's goal of reducing the number of highway-related fatalities and injuries. In addition, it was judged to be an "excellent fit" for the Injury Control Research Center's (ICRC) faculty and, it complements the ICRC's mission. Click here for details about current research projects.