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2002-2003 GRAND ROUNDS SCHEDULE
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September 2002	January 2003
October 2002	February 2003
November 2002	March 2003
December 2002	April 2003
	May 2003

2002/2003 GRAND ROUNDS
"The University of Alabama School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The University of Alabama School of Medicine designates this educational activity for a maximum of one category 1 credit(s) toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity."

September 2002

9/3/02
11:00am

Auditorium
2nd Floor
CPM

No Grand Rounds Scheduled

9/10/02
11:00am

Auditorium
2nd Floor
CPM

No Grand Rounds Scheduled

9/17/02
11:00am

Auditorium
2nd Floor
CPM

No Grand Rounds Scheduled

9/24/02

Auditorium
2nd Floor
CPM

Genetics of Schizophrenia
Vishwajit L. Nimgaonkar, M.D., Ph.D.
Professor of Psychiatry and Human Genetics
University of Pittsburgh
The genetic etiology for common psychiatric conditions such as schizophrenia and bipolar disorder are well established, but efforts to map susceptibility genes have not yielded consistent results. Two critical features have hampered intensive efforts: as complex mode of inheritance (with the possibility of genes of relatively small effect) and inadequate knowledge about the pathogenesis. These features are not unique to psychiatric illnesses: they dog genetic studies of common non-psychiatric disorders too. Using our ongoing studies, I will review the strengths and pitfalls of current research. I will focus on our recent work involving candidate genes for schizophrenia. In closing, I will discuss our recently initiated studies with UAB faculty. Objectives: 1) To review prior research into the genetics of schizophrenia. 2) To discuss the advantages and disadvantages of such approaches. 3) To describe ongoing work at the University of Pittsburgh which is currently focused on candidate genes. References: N/A

Questions or comments concerning these activities? Write, Call, FAX, or E-mail:
Carol Schaffhausen, Coordinator of Educational Services
The University of Alabama at Birmingham
115 Smolian Psychiatric Clinic
1700 Seventh Avenue South
Birmingham, AL 35294-0018
PHONE 934-1306 FAX 934-4659 cschaff@uabmc.edu

PSYCHIATRY HOME CLINICAL SERVICES Center for Psychiatric Medicine Adult Psychiatry Child/Adolescent Psychiatry Geriatric Psychiatry Addiction Recovery Program Community Psychiatry EDUCATION Psychiatry Residency Training Psychiatry Fellowship Programs Medical Education Psychology Training Grand Rounds RESEARCH Clinical Research Behavioral Neurobiology LINKS Other Psychiatry Sites	*The Department of Psychiatry* *and* *Behavioral Neurobiology*
	2002/2003 GRAND ROUNDS "The University of Alabama School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The University of Alabama School of Medicine designates this educational activity for a maximum of 1 hour in category 1 credit toward the AMA Physician's Recognition Award. Each physician should claim only those hours of credit that he/she actually spent in the activity." October 2002
	10/1/02 11:00am	Auditorium 2nd Floor CPM	No Grand Rounds Scheduled
	10/8/02 11:00am	Auditorium 2nd Floor CPM	Unique Minority: Implications of Deafness and Other Hearing Losses on Patients' Treatment and Recovery Frances Ralston, Ph.D. Licensed Clinical Psychologist Birmingham, Alabama After describing training and background as a specialist to work with Deaf and hard of hearing patients, this unique population will be defined and described. There is a wide variation of intelligence, cognitive abilities, psychosocial experiences as well a linguistic abilities. About one-third of this population have additional disabilities which will be briefly discussed. Then, implications of cultural identity and communication barriers will be related to treatment and recovery outcomes. Objectives: 1) Participants will recognize the wide diversity of this unique population with corresponding variety of needs. 2) Participants will increase their awareness of how communication, identity, and cultural identity can impact on patients' treatment or recovery. 3) Participants will appreciate the need for teamwork and creative use of resources for treatment planning options for deaf and hard of hearing patients. References: N/A
	10/15/02 11:00am	Auditorium 2nd Floor CPM	No Grand Rounds Scheduled
	10/22/02	Auditorium 2nd Floor CPM	No Grand Rounds Scheduled
	10/29/02	Auditorium 2nd Floor CPM	Weight Gain in Schizophrenia David B. Allison, Ph.D., Professor of Public Health Head, Section on Statistical Genetics UAB Department of Biostatistics Associate Director, Clinical Nutrition Research Center UAB Department of Nutrition Sciences This presentation will focus on antipsychotic induced weight gain. First the magnitude of the problem will be covered. This will be followed by presentation of potential deleterious outcomes of this weight gain and putative mechanisms of action. Finally, data will be presented on potential methods for treatment and prevention of antipsychotic induced weight gain. Objectives: 1) To understand the magnitude of weight gain induced by various antipsychotic drugs. 2) To become informed about the distribution of body mass index among people with schizophrenia. 3) To learn about potential mechanisms of antipsychotic-induced weight gain. 4) To learn about potential treatment and prevention strategies and the data regarding their safety and efficacy. References: 1) Green, AI, Patel, JK, Goisman, R., Allison, D. B., & Blackburn, GL. (2000). Weight Gain from Novel Antipsychotic Drugs: Need for Action. General Hospital Psychiatry, 22, 224-235. 2) Allison, D. B., & Casey, D. E. (2001). Antipsychotic-induced weight gain: A review of the literature. Journal of Clinical Psychiatry, 62 (suppl 7), 22-31. 3) Allison, D. B., Mentore, J. M., Heo, M. Chandler, L., Cappelleri, J. C., Infante, M., & Weiden, P. (1999). Meta-analysis of the effects of anti-psychotic medication on weight gain. American Journal of Psychiatry, 156: 1686-1696. 4) Fontaine, K. R., Heo, M., Harrigan, E. P., Shear, C. L., Lakshminarayanan, M., Casey, D. E. & Allison, D. B. (2001). Estimating the consequences of anti-psychotic induced weight gain on health and mortality rate. Psychiatry Research, 101, 277-288.
	Questions or comments concerning these activities? Write, Call, FAX, or E-mail: Carol Schaffhausen, Coordinator of Educational Services The University of Alabama at Birmingham 115 Smolian Psychiatric Clinic 1700 Seventh Avenue South Birmingham, AL 35294-0018 PHONE 934-1306 FAX 934-4659 cschaff@uabmc.edu

PSYCHIATRY HOME CLINICAL SERVICES Center for Psychiatric Medicine Adult Psychiatry Child/Adolescent Psychiatry Geriatric Psychiatry Addiction Recovery Program Community Psychiatry EDUCATION Psychiatry Residency Training Psychiatry Fellowship Programs Medical Education Psychology Training Grand Rounds RESEARCH Clinical Research Behavioral Neurobiology LINKS Other Psychiatry Sites	*The Department of Psychiatry* *and* *Behavioral Neurobiology*
	2002/2003 GRAND ROUNDS "The University of Alabama School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The University of Alabama School of Medicine designates this educational activity for a maximum of 1 hour in category 1 credit toward the AMA Physician's Recognition Award. Each physician should claim only those hours of credit that he/she actually spent in the activity." November 2002
	11/5/02 11:00am	Auditorium 2nd Floor CPM	Advances in Psychopharmacology in the Elderly with Supporting Abstracts Bruce G. Pollock, M.D., Ph.D. Professor of Psychiatry, Pharmacology, & Pharmaceutical Sciences University of Pittsburgh School of Medicine Age associated changes in pharmacokinetics and dynamics that impact on the use of antidepressants will be discussed. The importance of the P450 drug metabolizing enzymes for understanding drug interactions will be emphasized. Objectives: 1) To understand pharmacodynamic differences amongst newer antidepressants that may affect clinical use in older patients. 2) To discuss the differential pharmacokinetics of the antidepressants that may impact their clinical use in the elderly patients. 3) Apply sound principles in formulating effective approaches to geriatric depression pharmacotherapy taking into account medical co-morbidity and drug interactions. References: N/A We gratefully acknowledge an educational grant from Forest Pharmaceuticals, Inc. provided to support Dr. Pollock's visit.
	11/12/02 11:00am	Auditorium 2nd Floor CPM	Diagnostic Compared to Abstinence Outcomes of Treatment Among Homeless Persons with Cocaine Disorders Joseph E. Schumacher, Ph.D., Associate Professor (secondary appointment) Division of Community Psychiatry - Substance Abuse UAB Department of Psychiatry and Behavioral Neurobiology This presentation demonstrates the utility of DSM-III-R diagnostic change variables as an adjunct to traditional drug toxicology measures of treatment outcomes. Objectives: 1) To teach audience how to use DSM change variables as an outcome measure. 2) To show audience how to assess treatment outcome with DSM change variables. 3) To inform audience how DSM change variables compare to drug toxicology measures of treatment outcome. References: Will be distributed at the presentation
	11/19/02 11:00am	Auditorium 2nd Floor CPM	Calming Emotional Storms: The UAB Borderline Disorder Program Warren T. Jackson III, Ph.D., Assistant Professor Andree Stoves, M.D., Assistant Professor James Flournoy, Jr., Ph.D., Postdoctoral Fellow UAB Department of Psychiatry and Behavioral NeurobiologyIn my relationships I have always been able to tell when it’s time to stop....when the situation causes more pressure and stress then I know something is wrong. The times I have tried to ignore my instincts and feelings it has been a mess for all involved. I do know myself well enough now to go with my instinct and be obedient to what I feel it right.Borderline personality disorder (BPD) is a biopsychosocial disorder characterized by emotional instability, behavioral impulsivity, disrupted cognition, and conflicted interpersonal relationships that is difficult to treat and quite costly in terms of clinical services. Objectives: 1) Review new APA practice guidelines for the treatment of patients with BPD. 2) Provide update on development of UAB Borderline Disorder Program. 3) Present an introduction to Dialectical Behavior Therapy (DBT). 4) Summarize progress of related research program. References: American Psychiatric Association Practice guidelines for the treatment of patients with borderline personality disorder. Am J Psychiatry 2001; 158 (Oct suppl): 1-52.
	11/26/02 11:00am	Auditorium 2nd Floor CPM	NO GRAND ROUNDS SCHEDULED. HAPPY THANKSGIVING!

	Questions or comments concerning these activities? Write, Call, FAX, or E-mail: Carol Schaffhausen, Coordinator of Educational Services The University of Alabama at Birmingham 115 Smolian Psychiatric Clinic 1700 Seventh Avenue South Birmingham, AL 35294-0018 PHONE 934-1306 FAX 934-4659 cschaff@uabmc.edu

PSYCHIATRY HOME CLINICAL SERVICES Center for Psychiatric Medicine Adult Psychiatry Child/Adolescent Psychiatry Geriatric Psychiatry Addiction Recovery Program Community Psychiatry EDUCATION Psychiatry Residency Training Psychiatry Fellowship Programs Medical Education Psychology Training Grand Rounds RESEARCH Clinical Research Behavioral Neurobiology LINKS Other Psychiatry Sites	*The Department of Psychiatry* *and* *Behavioral Neurobiology*
	2002/2003 GRAND ROUNDS "The University of Alabama School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The University of Alabama School of Medicine designates this educational activity for a maximum of 1 hour in category 1 credit toward the AMA Physician's Recognition Award. Each physician should claim only those hours of credit that he/she actually spent in the activity." December 2002
	12/3/02 11:00am	Auditorium 2nd Floor CPM	Antipsychotic Non Adherence in Schizophrenia: An Update on Phenomenology and Interventions Matthew J. Byerly, M.D., Clinical Assistant Professor of Psychiatry University of Texas Southwestern Medical Center at Dallas Director, Schizophrenia Research Program UT Southwestern Medical Center, Campus Site The presentation will provide an update of information regarding antipsychotic non-adherence in schizophrenia, addressing issues of clinical frequency, impact, and treatment interventions. Objectives: At the completion of the talk, participants should be able to describe: 1) The frequency of antipsychotic non-adherence in schizophrenia 2) The impact of antipsychotic non-adherence in schizophrenia 3) The clinical correlates of antipsychotic non-adherence in schizophrenia 4) The value and feasibility of non-adherence interventions in schizophrenia *We gratefully acknowledge an educational grant from Bristol-Meyers Squibb provided to support Dr. Byerly's visit.*
	12/10/02 11:00am	Auditorium 2nd Floor CPM	Beyond Efficacy: Improving Adherence in the Real World of You and Your Patients Stephen Mark Goldfinger, M.D., Professor and Vice Chair Department of Psychiatry, State University of New York, Downstate Medical Center This presentation will explore the interface of medication, personal, treatment dyad and broader systemic issues on patient medication and overall treatment adherence. Strategies to improve adherence will be a major focus. Objectives: The learner will: 1) Identify five barriers to adherence 2) Identify five strategies for improving medication adherence 3) Describe the impact of side effects on medication adherence References: 1. Frank E. Enhancing patient outcomes: treatment adherence. [Review] [7 refs] [Journal Article. Review. Review, Tutorial] *Journal of Clinical Psychiatry. 58 Suppl 1:11-4, 1997.* LHL* has a current print subscription. 2. Perkins DO. Adherence to antipsychotic medications. [Review] [54 refs] [Journal Article. Review. Review, Tutorial] Journal of Clinical Psychiatry. 60 Suppl 21:25-30, 1999. LHL* has a current print subscription (available at UAB Lister Hill Medical Library) We gratefully acknowledge an educational grant from Janssen Pharmaceutica provided to support Dr. Goldfinger's visit.*
	12/17/02 11:00am	Auditorium 2nd Floor CPM	No Grand Rounds Scheduled
	12/24/02 11:00am	Auditorium 2nd Floor CPM	NO GRAND ROUNDS SCHEDULED. HAPPY HOLIDAYS!
	12/31/02	Auditorium 2nd Floor CPM	NO GRAND ROUNDS SCHEDULED. HAPPY HOLIDAYS!
	Questions or comments concerning these activities? Write, Call, FAX, or E-mail: Carol Schaffhausen, Coordinator of Educational Services The University of Alabama at Birmingham 115 Smolian Psychiatric Clinic 1700 Seventh Avenue South Birmingham, AL 35294-0018 PHONE 934-1306 FAX 934-4659 cschaff@uabmc.edu

PSYCHIATRY HOME CLINICAL SERVICES Center for Psychiatric Medicine Adult Psychiatry Child/Adolescent Psychiatry Geriatric Psychiatry Addiction Recovery Program Community Psychiatry EDUCATION Psychiatry Residency Training Psychiatry Fellowship Programs Medical Education Psychology Training Grand Rounds RESEARCH Clinical Research Behavioral Neurobiology LINKS Other Psychiatry Sites	*The Department of Psychiatry* *and* *Behavioral Neurobiology*
	2002/2003 GRAND ROUNDS "The University of Alabama School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The University of Alabama School of Medicine designates this educational activity for a maximum of 1 hour in category 1 credit toward the AMA Physician's Recognition Award. Each physician should claim only those hours of credit that he/she actually spent in the activity." January 2003
	1/7/03 11:00am	Auditorium 2nd Floor CPM	Basic Neuroscience of Experience Robert F. Ackermann, Ph.D., Associate Professor UAB Department of Psychiatry and Behavioral Neurobiology This presentation will review some animal and human data that provide insights into the characteristics of neuronal mechanisms that generate various experiential phenomena. Objectives: This presentation's objective will be to familiarize participants with some basic neuroscience findings that provide insight into the creation and maintenance of conscious perceptual and emotional states. References: Llinas, R. and Ribary, U. (2001) Consciousness and the brain: the thalamocortical dialogue in health and disease. Ann. N.Y. Acad. Sci., 929: 166-175
	1/14/03 11:00am	Auditorium 2nd Floor CPM	Depression, Cardiovascular Disease, and Cardiac Death Alexander H. Glassman, M.D. Professor of Clinical Psychiatry, College of Physicians & Surgeons Columbia University, N.Y.C. Director, Department of Clinical Psychopharmacology New York State Psychiatric Institute This talk will be based on the SADHART study published in JAMA in August 2002. This was a study of the safety and efficacy of an SSRI in 400 depressed patients immediately post MI. It will include data from both the SADHART and the yet to be published ENRICHD study of psychotherapy after heart attack. Epidemiological data that prompted these studies will be reviewed. That data convincingly showed that depression in otherwise healthy individuals followed for years leads to a 70 or 80 % increase in the risk of first heart attacks and cardiovascular deaths. Data is also convincing that the occurrence of depression in the immediate post infarction period carries a threefold increase in risk of cardiovascular deaths. Interestingly the mechanisms in these two situations appears to be different. The SADHART data in addition to demonstrating the safety and efficacy of sertraline in acute coronary syndromes, showed a 23% reduction in the occurrence of life threatening cardiovascular events. Although not statistically significant, in association with other recent observations this gives a strong signal that antidepressant drug treatment in post infarction patients can improve medical outcomes. Objectives: 1) Understanding the relationship between major depression and ischemic heart disease. 2) Understanding the relationship between major and minor depression and ischemic heart disease. 3) Understanding the safety and efficacy of antidepressant drugs in the post-infarction. *We gratefully acknowledge an unrestricted educational grant from Pfizer, Inc. provided to support Dr. Glassman's visit.*
	1/21/03 11:00am	Auditorium 2nd Floor CPM	Diagnosis and Management of Neurosyphilis for the 21st Century Edward W. Hook, III, M.D. Professor of Medicine, Infectious Diseases University of Alabama at Birmingham Objectives: 1) To understand when neurologic involvement may occur over the natural history of untreated syphilis 2) To understand diagnostic strategies for neurosyphilis diagnosis 3) To understand currently recommended therapies for patients with neurosyphilis References: TBA
	1/28/03 11:00am	Auditorium 2nd Floor CPM	Chemobrain, Fatigue, and Focalin Rodney O. Tucker, M.D., Assistant Professor UAB Center for Palliative Care Department of Psychiatry and Behavioral Neurobiology Objectives: 1) Introduce attendees to the concept of neurocognitive dysfunction after cytotoxic chemotherapy 2) Describe multi-symptom nature of the post-chemotherapy patient 3) Introduce attendees to the ongoing study with Dexmethylphenidate in the treatment of Fatigue and Neurobehavioral Function Related to Chemotherapy in Adult Cancer Patients

	Questions or comments concerning these activities? Write, Call, FAX, or E-mail: Carol Schaffhausen, Coordinator of Educational Services The University of Alabama at Birmingham 115 Smolian Psychiatric Clinic 1700 Seventh Avenue South Birmingham, AL 35294-0018 PHONE 934-1306 FAX 934-4659 cschaff@uabmc.edu

PSYCHIATRY HOME CLINICAL SERVICES Center for Psychiatric Medicine Adult Psychiatry Child/Adolescent Psychiatry Geriatric Psychiatry Addiction Recovery Program Community Psychiatry EDUCATION Psychiatry Residency Training Psychiatry Fellowship Programs Medical Education Psychology Training Grand Rounds RESEARCH Clinical Research Behavioral Neurobiology LINKS Other Psychiatry Sites	*The Department of Psychiatry* *and* *Behavioral Neurobiology*
	2002/2003 GRAND ROUNDS "The University of Alabama School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The University of Alabama School of Medicine designates this educational activity for a maximum of 1 hour in category 1 credit toward the AMA Physician's Recognition Award. Each physician should claim only those hours of credit that he/she actually spent in the activity." February 2003
	2/4/03 11:00am	Auditorium 2nd Floor CPM	Mental Illness and Osteoporosis John J. Spollen III, M.D. Assistant Professor, Department of Psychiatry University of Arkansas for Medical Sciences There are several specific mental illnesses that have been reported to have early bone loss and osteoporosis. Possible mechanisms include illness-induced hypercortisolemia and drug-induced hyperprolactinemia. Dr. Spollen will review the literature of mental illness-associated osteoporosis and present new data on bone physiology in patients with schizophrenia. Objectives: The audience will be able to identify specific mental health populations potentially more at risk for osteoporosis, understand definitions and identity diagnostic techniques of osteopenia and osteoporosis, and describe potential mechanisms of mental illness-associated osteoporosis.
	2/11/03 11:00am	Auditorium 2nd Floor CPM	No Grand Rounds Scheduled
	2/18/03 11:00am	Auditorium 2nd Floor CPM	Clinical Vignettes in Child Consultation Laura Montgomery-Barefield, M.D., Assistant Professor Susan Isbill, Ph.D., Assistant Professor Division of Child & Adolescent Psychiatry UAB Department of Psychiatry and Behavioral Neurobiology Discuss the evaluation of suicide potential in children and adolescents. Objectives: To review clinical presentations of child/adolescent suicide risk factors. References: TBA
	2/25/03	Auditorium 2nd Floor CPM	Department of Psychiatry & Behavioral Neurobiology Ninth Residents Versus Faculty Scholar's Bowl Moderated by Daniel C. Dahl, M.D. Assistant Professor and Residency Training Director Department of Psychiatry and Behavioral Neurobiology University of Alabama at Birmingham A rapid-pace, information-packed hour of questions in which a group of our residents will compete against a group of faculty members for the title of Scholar's Bowl Champions of 2003. Dr. Dahl will serve as moderator and will provide a series of challenging psychiatric as well as general knowledge questions. The faculty won last year but the residents were in it until the end. Who will win this year? You won't want to miss it! Objective: To stimulate review of the Psychiatric literature.

	Questions or comments concerning these activities? Write, Call, FAX, or E-mail: Carol Schaffhausen, Coordinator of Educational Services The University of Alabama at Birmingham 115 Smolian Psychiatric Clinic 1700 Seventh Avenue South Birmingham, AL 35294-0018 PHONE 934-1306 FAX 934-4659 cschaff@uabmc.edu

PSYCHIATRY HOME CLINICAL SERVICES Center for Psychiatric Medicine Adult Psychiatry Child/Adolescent Psychiatry Geriatric Psychiatry Addiction Recovery Program Community Psychiatry EDUCATION Psychiatry Residency Training Psychiatry Fellowship Programs Medical Education Psychology Training Grand Rounds RESEARCH Clinical Research Behavioral Neurobiology LINKS Other Psychiatry Sites	*The Department of Psychiatry* *and* *Behavioral Neurobiology*
	2002/2003 GRAND ROUNDS "The University of Alabama School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The University of Alabama School of Medicine designates this educational activity for a maximum of 1 hour in category 1 credit toward the AMA Physician's Recognition Award. Each physician should claim only those hours of credit that he/she actually spent in the activity." March 2003
	3/4/03 11:00am	Auditorium 2nd Floor CPM	Annual C.J. Rosecrans Memorial Lecture The Required Elements of Cognitive Therapy: Achieving Technical Merit While Maintaining Artistic Impression Cory F. Newman, Ph.D., ABPP Director, Center for Cognitive Therapy Associate Professor of Psychology, in Psychiatry University of Pennsylvania, School of Medicine This lecture will highlight the key components of cognitive therapy, such as a structured session, collaborative empiricism, and between-sessions homework assignments. In addition, the methods of cognitive therapy case formulation will be described, with emphasis on the concept of schemas. Further, it will be demonstrated how an individualized approach to treatment can lead to novel, creative applications of the model that facilitate patients' learning, and solidify the therapeutic relationship. Objectives: 1) Learn how to conduct well-organized, time-effective therapy sessions. 2) Understand and apply a schema-focused approach to case formulation. 3) Witness examples of using such elements as Socratic questions, hypothetical exercises, and creative analogies and metaphors in the service of therapeutic change. 4) Review some of the latest data on the efficacy of cognitive therapy. References: 1) Newman, C.F. (1994). Cognitive therapy of anxiety disorders. In B.B. Wolman & G. Stricker (Eds.), Anxiety and Related Disorders: A Handbook (pp. 376-400). New York: Wiley Interscience. 2) Newman, C.F., & Haaga, D.A.F. (1995). Cognitive skills training. In W. O'Donohue & L. Krasner (Eds.), Handbook of Psychological Skills Training: Clinical Techniques and Applications (pp. 119-143). 3) Strunk, D. R., & DeRubeis, R. J. (2002). Cognitive therapy for derpession: a Review of its efficacy. Journal of Cognitive Psychotherapy: An International Quarterly. 15(4), 289-297.
	3/11/03 11:00am	Auditorium 2nd Floor CPM	Program for Assertive Community Treatment (PACT): Hospital without Walls Farrukh Jamil, M.D. PG-IV Resident in Psychiatry UAB Department of Psychiatry & Behavioral Neurobiology Assess the outcome and effectiveness of the Assertive Community Treatment Model developed at UAB Community Psychiatry Program. Objective: To bring awareness regarding the Assertive Community Psychiatry treatment
	3/18/03 11:00am	Auditorium 2nd Floor CPM	Utilizing Antipsychotics in Acute Agitation Neal Kaye, M.D., DFAPA Assistant Clinical Professor of Psychiatry and Human Behavior Assistant Clinical Professor of Family Medicine Jefferson Medical College Objectives: 1) Short review of basic science of aggression theory 2) Review medication approaches used in agitation/aggression 3) Focus on IM antipsychotics in acute aggression/psychosis *We gratefully acknowledge an unrestricted educational grant from Pfizer, Inc. provided to support Dr. Kaye's visit.*
	3/25/03	Auditorium 2nd Floor CPM	NO GRAND ROUNDS SCHEDULED - Spring Break

	Questions or comments concerning these activities? Write, Call, FAX, or E-mail: Carol Schaffhausen, Coordinator of Educational Services The University of Alabama at Birmingham 115 Smolian Psychiatric Clinic 1700 Seventh Avenue South Birmingham, AL 35294-0018 PHONE 934-1306 FAX 934-4659 cschaff@uabmc.edu

PSYCHIATRY HOME CLINICAL SERVICES Center for Psychiatric Medicine Adult Psychiatry Child/Adolescent Psychiatry Geriatric Psychiatry Addiction Recovery Program Community Psychiatry EDUCATION Psychiatry Residency Training Psychiatry Fellowship Programs Medical Education Psychology Training Grand Rounds RESEARCH Clinical Research Behavioral Neurobiology LINKS Other Psychiatry Sites	*The Department of Psychiatry* *and* *Behavioral Neurobiology*
	2002/2003 GRAND ROUNDS "The University of Alabama School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The University of Alabama School of Medicine designates this educational activity for a maximum of 1 hour in category 1 credit toward the AMA Physician's Recognition Award. Each physician should claim only those hours of credit that he/she actually spent in the activity." April 2003
	4/1/03 11:00am	Auditorium 2nd Floor CPM	CURRENTLY NO GRAND ROUNDS SCHEDULED
	4/8/03 11:00am	Auditorium 2nd Floor CPM	Clinical and Pathophysiological Aspects of Mood Disorders Xiaohua Li, M.D. Assistant Professor, Adult Psychiatry and Behavioral Neurobiology UAB Department of Psychiatry & Behavioral Neurobiology Mood disorders are a group of severe mental illnesses that require clinical challenges for diagnosis and treatment. Increased evidence suggests that mood disorders are caused by the complicated biological abnormalities in the brain, but the pathophysiology of mood disorders has not been fully identified. New research findings support the role of brain derived neurotrophic factor (BDNF) in the development and the treatment of mood disorders. Objectives: 1) Discuss the clinical evaluation and treatment concerns of mood disorders. 2) Provide information of the pathophysiology of mood disorders. 3) Present the recent research data that aims to improve the diagnosis and treatment of mood disorders. References: 1. Li X. Bijur GN. Jope RS. Glycogen synthase kinase-3beta, mood stabilizers, and neuroprotection. [Review] [46 refs] [Journal Article. Review. Review, Academic] Bipolar Disorders. 4(2):137-44, 2002 Apr. 2. Li X. Ketter TA. Frye MA. Synaptic, intracellular, and neuroprotective mechanisms of anticonvulsants: are they relevant for the treatment and course of bipolar disorders?. [Review] [122 refs] [Journal Article. Review. Review, Academic] Journal of Affective Disorders. 69(1-3):1-14, 2002 May. 3. Mai L. Jope RS. Li X. BDNF-mediated signal transduction is modulated by GSK3beta and mood stabilizing agents. [Journal Article] Journal of Neurochemistry. 82(1):75-83, 2002 Jul. 4. De Sarno, P.D., Li, X., Jope, R.S. Regulation of Akt and glycogen synthase kinase-3 phosphorylation by sodium valproate and lithium. Neuropharmacology. 43:1158-64, 2002.
	4/15/03 11:00am	Auditorium 2nd Floor CPM	The Diagnosis and Pharmacotherapy of Autism and Other Pervasive Developmental Disorders Christopher J. McDougle, M.D. Albert E. Sterne Professor and Chairman, Department of Psychiatry Professor of Pediatrics and Neurobiology Indiana University School of Medicine This presentation will briefly review the diagnosis of the five subtypes of pervasive developmental disorders (PDDs). The target symptoms that are often responsive to pharmacotherapy, including inattention and hyperactivity, interfering repetitive phenomena, and self-injury and aggression, will be discussed. Medication treatment strategies that can be effective for these symptom clusters will be presented. Potential adverse effects associated with the use of these medications in this patient population will be reviewed. Objectives: 1) The audience will have a better understanding of the diagnosis of the subtypes of pervasive developmental disorders (PDDs). 2) The audience will have a better understanding of the medication treatment of target symptoms associated with PDDs. 3) The audience will have a better understanding of the potential adverse effects of medications used to treat the target symptoms associated with PDDs. *References:* 1) McCracken JT. McGough J. Shah B. Cronin P. Hong D. Aman MG. Arnold LE. Lindsay R. Nash P. Hollway J. McDougle CJ., et.al. Research Units on Pediatric Psychopharmacology Autism Network. Risperidone in children with autism and serious behavioral problems. [see comments.]. [Clinical Trial. Journal Article. Multicenter Study. Randomized Controlled Trial] New England Journal of Medicine. 347(5):314-21, 2002 Aug 1. 2) Posey DJ. McDougle CJ. The pharmacotherapy of target symptoms associated with autistic disorder and other pervasive developmental disorders. [Review] [171 refs] [Journal Article. Review. Review, Tutorial] Harvard Review of Psychiatry. 8(2):45-63, 2000 Jul-Aug. *We gratefully acknowledge an educational grant from Janssen Pharmaceutica provided to support Dr. McDougle's visit.*
	4/22/03	Auditorium 2nd Floor CPM	Cholinergic Therapies and Alzheimer's Disease Martin Rhys Farlow, M.D. Professor and Vice Chairman for Research Indiana University School of Medicine Although no pharmacological treatments have been proven to alter pathology of AD, acetylcholinesterase inhibitor (AChE-I) therapy offers symptomatic improvement or delays in the progression of cognitive, behavioral, and functional deficits. Tacrine, donepezil, rivastigmine, and galantamine are the best study agents in this class. These drugs have varying pharmacokinetic, safety and tolerability profiles that can impact patient outcome. Specifically, certain metabolic parameters (i.e., half-life and route of metabolism/elimination) can affect safety and tolerability and become important when a switch from one agent to another is contemplated. The presentation will attempt to detail the various treatments of AD. Objectives: 1. To describe key characteristics of Alzheimer disease (AD) 2. To show how cholinesterase inhibitors are believed to work in AD. 3. To describe other approaches to AD therapy. References: Handout will be provided. *We gratefully acknowledge an educational grant from Novartis Pharmaceuticals Corporation provided to support Dr. Farlow's visit.*
	4/29/03	Auditorium 2nd Floor CPM	Sports-Related Concussion: Evaluation, Management, and Return to Play Issues Paul Blanton, Ph.D., Research Associate Professor; Departments of Psychology and Surgery/Division of Neurosurgery. Director, Clinical Neuropsychological Service, Department of Surgery/Division of Neurosurgery This lecture presentation is intended to provide attendees with an introduction to Sports-Related Concussion (SRC) and its incidence, common symptoms, evaluation, and management. A case study will be presented to illustrate all-too-frequent mistakes in evaluation, management, and return to play decision making. the presentation will conclude with a brief discussion of future directions for clinical research. Objectives: To provide attendees with introductory information regarding the incidence, mechanics, and neurobehavioral consequences of sports-related mild TBI (i.e., concussion); The assessment of SRC; management of symptoms; and factors used in determining return to play status.
	Questions or comments concerning these activities? Write, Call, FAX, or E-mail: Carol Schaffhausen, Coordinator of Educational Services The University of Alabama at Birmingham 115 Smolian Psychiatric Clinic 1700 Seventh Avenue South Birmingham, AL 35294-0018 PHONE 934-1306 FAX 934-4659 cschaff@uabmc.edu

PSYCHIATRY HOME CLINICAL SERVICES Center for Psychiatric Medicine Adult Psychiatry Child/Adolescent Psychiatry Geriatric Psychiatry Addiction Recovery Program Community Psychiatry EDUCATION Psychiatry Residency Training Psychiatry Fellowship Programs Medical Education Psychology Training Grand Rounds RESEARCH Clinical Research Behavioral Neurobiology LINKS Other Psychiatry Sites	*The Department of Psychiatry* *and* *Behavioral Neurobiology*
	2002/2003 GRAND ROUNDS "The University of Alabama School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The University of Alabama School of Medicine designates this educational activity for a maximum of 1 hour in category 1 credit toward the AMA Physician's Recognition Award. Each physician should claim only those hours of credit that he/she actually spent in the activity." May 2003
	5/6/03 11:00am	Auditorium 2nd Floor CPM	Residency Training in Community Psychiatry Tanveer Sobhan, M.D., M.P.H. Chief Resident in Psychiatry PG-IV Resident in Psychiatry UAB Department of Psychiatry & Behavioral Neurobiology Treatment of SMI patients is moving away from hospitals to the natural setting of their own community. Hence training of psychiatry residents in the "front line" of the community, i.e., training community psychiatry is imperative. Objectives: To discuss various issues related to integrating community psychiatry in the residency training curriculum. References: Handout material will be available at the presentation.
	5/13/03 11:00am	Auditorium 2nd Floor CPM	Grand Rounds Canceled due to Residency Site Visit
	5/20/03 11:00am	Auditorium 2nd Floor CPM	NO GRAND ROUNDS SCHEDULED APA ANNUAL MEETING May 17 - 22, 2003 San Francisco, CA
	5/27/03	Auditorium 2nd Floor CPM	"Depression": A Multi-systemic Illness James N. Hall, Jr., M.D. Objectives: 1.To propose a proposed mechanism of illness, in which “depression” is one among many sequellae: a) A syndrome of neuron dysregulation resulting from chronic exposure to endocrine stress response b) That is, genetically vulnerable individuals become “stuck” in a sustained state of elevated stress hormones, with mood symptoms arising as a secondary epiphenomenon c) Sustained elevation of endocrine stress response appears to also induce harm to other organ systems – i.e., depression is an illness affecting multiple systems, which stands in contrast to our traditional perception of it as “just” a mood or emotional disorder. 2. To review immune, endocrine, and phospholipid aberrations in depression. a)Lymphocytes, especially Killer T Cells b)Corticotropic axis c) Thyroid axis d)Growth hormone/somatostatin system e) Melatonin and prolactin dysregulation f) Monoamine aberrations g) Brain Derived Neurotrophic Factor and h) Phospholipid dysregulation 3. To consider the grave impact of cardiac, glucose, and bone effects of depression
	Questions or comments concerning these activities? Write, Call, FAX, or E-mail: Carol Schaffhausen, Coordinator of Educational Services The University of Alabama at Birmingham 115 Smolian Psychiatric Clinic 1700 Seventh Avenue South Birmingham, AL 35294-0018 PHONE 934-1306 FAX 934-4659 cschaff@uabmc.edu