• Cystic Fibrosis (CF) Clinical & Translational Core
    Cystic Fibrosis (CF) Clinical & Translational Core

    Director: Steven M. Rowe, M.D.
    Email: GFJCFRC@uab.edu
    Phone: 975-6385

    Website:  http://www.uab.edu/cfcenter

    The  CF Clinical  & Translational Assay Core examines efficacy and toxicity  of emerging CF therapeutics in human cells and tissues using  human primary nasal airway epithelial cells and bronchial airway epithelial cells (from bronchoscopy or other surgical remnant tissues).  The Core also provides expertise in the nasal potential difference measurement, an important endpoint in cystic fibrosis clinical trials, and a means to understand pathogenesis of cystic fibrosis and other metabolic diseases.  These clinical assays help bridge the gap between preclinical animal studies and clinical trials and contribute to therapeutic development in the CF Research Center.

    If you have any questions please contact us at:  GFJCFRC@uab.edu

    Core capabilities include:

    • Nasal potential difference assay in human subjects
    • Primary airway epithelial cells
    • CF bacterial isolates