• Epitope Recognition & Immunoreagent Core
    Epitope Recognition & Immunoreagent Core

    Director: Mary Ann Accavitti-Loper, PhD
    Email: maal@uab.edu
    Phone: 205-934-0913

    Website -https://www.uab.edu/medicine/genetics/epitope-recognition-and-immunoreagent-core-facility-eric

    Contact
    Fran Allen, Associate Director
    fallen@uab.edu
    205-934-7156

     The Epitope Recognition and Immunoreagent Core (ERIC) evolved from expansion and diversification of the UAB Hybridoma Core Facility established in 1982. Services provided by the ERIC include: procurement and housing of pathogen-free rodents, design and evaluation of peptide antigens, immunization, sera testing, performance and screening of fusions, single cell cloning, isotyping, large-scale mab production and purification. The ERIC is committed to maintaining the highest possible success rate for the development of novel monoclonal reagents.  As a result, the ERIC utilizes unique strategic protocols that increase the probability of obtaining specific Mabs against poorly immunogenic substances, highly conserved proteins or one particular epitope on a complex molecule. The ERIC maintains an inventory of over 30 hybridomas against commonly requested cytokines, CD antigens, lymphocyte markers.  Services provided by the ERIC are offered to all UAB investigators as well as collaborators at other academic institutions. Requests for ERIC services should be directed to core director Dr. Mary Ann Accavitti-Loper (934-0913, maal@uab.edu)  or associate core director Ms. Fran Allen (934-7156, fallen@uab.edu).

    Equipment
    Tissue Culture Hoods, CO2 Incubators, Liquid nitrogen freezers and feed tanks, Automated microtiter plate washer, Spectrophotometer, Molecular Devices Plate reader

    Center Affiliations
    Comprehensive Arthritis
    Musculoskeletal and Autoimmunity Center

    Grant Affiliations
    Rheumatic Diseases Core Center: NIH P30 AR048311
    Hepato-renal Fibrocystic Diseases Core Center: P30 DK74038-01  
    Southeastern Regional Center for Excellence in Biodefense: UNC-CH 5-50780 
    Cystic Fibrosis Foundation: SORSCH05XO        

    Serves - UAB Internal and External