How to Submit Protocols

How to Submit Protocols

How to Submit Protocols

All submissions requiring IACUC review (i.e., new protocols, continuations, modifications) will be entered for review as they are received. Final approval may require a full committee review (FCR) which occurs on the last Wednesday of each month. Most documents are reviewed and approved via designated member review (DMR) which allows approval once all review concerns have been satisfactorily addressed.
***PLEASE NOTE: As of April 1, 2016, all New (Initial) and Third Year Renewal submissions must be made on the new electronic form (eForm) in IRAP. Paper forms will be accepted for Annual Renewals and Modifications only until January 1, 2017.
Note: All protocol-related paper documents
must be submitted by e-mail to Electronic submissions must be made through IRAP.

New Protocols, Competing Continuation/Renewal 

For new projects or competing continuation segments, the investigator must submit a new Animal Use Request/Registration (AUR) electronic form (eForm) to the IACUC Office. New eForms can be created by selecting "Create New" in the Lab Animals module of IRAP. For more information on creating, completing and submitting the eForm click here. Protocols subject to review at a convened IACUC meeting must be received 20 calendar days prior to the monthly meeting and any responses to the administrative review are due 2 work days before the meeting. See Submission Deadlines and Dates for more information.

Noncompeting Renewal

Annual review is performed to confirm that no changes have taken place in the approved activity which might require further consideration by the IACUC and to ensure that any new requirements of PHS, USDA or the institution are communicated to the investigator. Annual review of all projects is required, but can be accomplished in the case of non-competitive renewals by completion of an Annual Renewal of Approved Protocols form (through January 1, 2017) or by submission of an electronic form (eForm). Renewals on the paper form should be submitted to For guidance on submitting the eForm please click here. Once an eForm has been approved, a significant modification may substitute for an Annual review. See the Modification section below for more information.
Every 3 years the IACUC is required to perform a "de novo" or full review. For this review the eForm must be submitted. A Renewal/Update Reminder Notice sent 6 weeks prior to protocol expiration will indicate which form (type of review) is due based on the original approval date of the IACUC protocol.

Resubmission of Prior Approved Protocols

A new IACUC protocol must be started for grant applications involving previously approved animal procedures if they are competing continuations, or being submitted to a different funding agency. The Animal Use Request/Registration electronic form is required.

Training, Salary Support, and Administrative Parent Grants

These grants do not use animals directly, but may require an IACUC approval for the overall grant. All investigators who are listed within these grants as using animals must either submit a protocol or reference a currently approved protocol for the animal use indicated in the grant.

Modification of Approved Protocols

Any changes in the IACUC protocol (e.g., procedures, husbandry, or personnel) must be approved by the IACUC prior to implementation. Until January 1, 2017, modifications for existing protocols can be made using the Modification Request Form or currently approved AUR form. After this date or once an eForm has been submitted, all changes must be made to the approved eForm. Significant modifications, those not reviewed administratively (see Amendment Processing procedure), made to the eForm may substitute for an Annual Update, which means the 1-year review clock will be reset upon approval of the modification. For example, an Initial submission approved January 1 and significantly modified June 1 will not be due for update until June 1 of the next year.
Approval Numbers Issued To Protocols
Are Good For (1) Year From The Issuance Date