ABBREVIATION DEFINITIONS
| Am | Amphibians | bid | twice daily |
| C | Cats | BW | body weight |
| D | Dogs | gm | grams |
| F | Ferrets | h | hours |
| G | Gerbils | IM | intramuscularly |
| Gp | Guinea Pigs | IP | intraparitoneally |
| H | Hamsters | IV | intravenous |
| M | Mice | kg | kilograms |
| N | Nonhuman Primates | min | minutes |
| R | Rats | ml | milliliters |
| Rb | Rabbits | mg | milligrams |
| Re | Reptiles | PO | by mouth |
| Sh | Sheep | prn | as needed |
| Sw | Swine | q | every |
| SC | subcutaneously | ||
| sid | once daily | ||
| tid | three times daily | ||
| % | g/100ml |
Sources and References Provided By the Following: |
|
1. |
Hawk, Terrance C et al. Formulary for Laboratory Animals, 2nd edition, Iowa State University Press, Ames, Iowa, 1999. |
2. |
Flecknell, P. Laboratory Animal Anaesthesia, 2nd edition, Academic Press, San Diego CA, 1996. |
3. |
Baker, Bob, L Gerrity, S Cartner. Guidelines for Pre-Anesthetics, Tranquilizers, Anesthetics and Analgesics, University of Alabama at Birmingham, Animal Resources Program, Birmingham AL, 2005. |
4. |
Bramson,
Paul H et al. List of Anesthetic, Analgesic and Tranquilizer Drugs Frequently
Used
with the Common Laboratory Species: http://www.iacuc.pitt.edu/druglist.pdf#search='ketofen%20in%20primates' |
| C | 0.1-0.2
mg/kg BW IM, SC (1) 0.5-1.0 mg/kg BW PO prn (1) 1-3 mg/kg BW PO (2) 0.25-0.5 mg/kg BW IM, IV, SC (2) |
| D | 0.1-0.5 mg/kg
BW IV, IM, SC (1) 0.25-1.0 mg/kg BW PO prn (1) |
| F | 0.2-0.5 mg/kg BW IM, SC (1, 2) |
| G | Causes seizures |
| Gp | 2.5-5 mg/kg
BW IM (2) 0.5-1.0 mg/100gm BW IM (3) |
| H | 0.05mg/kg IM (3) |
| M | 1-2 mg/kg
BW IM (1) 2-5 mg/kg BW IP (1) 0.5-1.0 mg/kg IM (4) 0.075 mg/100gm BW IM (3) |
| N | 0.5-1.0 mg/kg
BW IM, SC 0.2 mg/kg BW IM (1) 0.25-1.0 mg/kg BW IM, SC (3) |
| R | 1-2 mg/kg
BW IM (1) 0.5 mg/100gm BW IM, SQ (3) |
| Rb | 1-2 mg/kg
BW IM (1) 5 mg/kg BW IM (1) 2mg/kg BW IM (1) 0.5-2.0 mg/kg BW IM (3) |
| Sh | 0.05-0.5
mg/kg BW IM (1) 0.55 mg/kg BW IV (1) 0.1 mg/kg BW IV (3) 0.5 mg/kg BW IM (3) |
| Sw | 0.11-0.22
mg/kg BW SC, IM, IV (1) 0.05-0.1 mg/kg BW IM (1) 0.03-0.22 mg/kg BW IM not to exceed 15mg total (1) 0.2-1.0 mg/kg BW IM not to exceed 15mg total (3) |
| C | 22
mg/kg BW IV, PO, SC tid (1) 5-10 mg/kg BW IM, IV, SC tid (1) 10-50 mg/kg BW PO tid (1) |
| D | 5-10 mg/kg
BW IM, IV, SC tid (1) 22 mg/kg BW IV, PO, SC tid (1) |
| Gp | May cause
enterocolitis (1) 6 mg/kg BW SC tid for 5 days (1) |
| H | Toxic (1) |
| M | 2-10 mg/100g
BW PO bid (1) 50-150 mg/kg BW SC bid (1) |
| N | 30 mg/kg
BW IM sid for 5 days (1) 5 mg/kg BW IM bid (1) 20mg/kg BW IM, IV, PO tid (1) |
| R | 50-150 mg/kg
BW SC (1) 50 mg/adult rat IP sid for 10days (1) |
| Rb | 10-25 mg/kg BW IM sid for 5-7 days (1) |
| C | 0.05
mg/kg BW IM, IV, SC q6h (1) 0.04-0.1 mg/kg BW IM, IV, SC (3) 0.05 mg/kg BW IM, SC (2) |
| D | 0.05 mg/kg
BW IM, IV, SC q6h (1) |
| F | 0.05 mg/kg
BW IM, SC (1, 2) 0.05 mg/kg BW IM, IV, SC (3) |
| G | 0.02-0.05
mg/kg BW SC, IM, IV (1) 0.04 mg/kg BW SC (2) |
| Gp | 0.02-0.05
mg/kg BW SC, IM, IV (1, 6)3 0.05 mg/kg BW SC (2) |
| H | 0.02-0.5
mg/kg BW SC, IM, IV (1) 0.04 mg/kg BW SC (2) 0.002-0.005 mg/100gm BW IM, IV, SC (3) |
| M | 0.05 mg/kg
BW SC, IM, IV (1) |
| N | 0.1 mg/kg
BW SC (1) 0.05 mg/kg BW SC, IM, IV (1) 0.05 mg/kg BW SC, IM (2) 0.04-0.1 mg/kg BW IM, IV, SC (3) |
| R | 0.04mg/kg
BW SC (1) 0.02- 0.05 mg/kg BW SC, IM, IV (1) 0.05 mg/kg BW IP, SC (2) 0.002-0.005 mg/100gm BW IM, IV, SC (3) 0.05-0.10 mg/kg BW SC (4) |
| Rb | 0.20 mg/kg
BW IM, IV, SC (1) |
| Sh | 0.04 mg/kg
BW IM (1) 0.13 mg/kg BW IV (1) 0.1-0.3 mg/kg BW IM, IV, SC (3) |
| Sw | 0.05-0.5
mg/kg BW SC (1) 0.044-0.4 mg/kg BW IM (1) 0.05 mg/kg BW SC, IM (2) 0.05-0.1 mg/kg BW IM, IV, SC (3) 0.04 mg/kg BW SC, IM, IV (4) |
| Am | 1.5-10 mg/kg BW IM SC sid (1) |
| C | 2.5-5 mg/kg
BW PO q12-24h (1) 2.5-5 mg/kg BW IM, SC as a loading dose (1) 5 mg/kg BW SC bid (1) 5mg/kg BW IV bid (1) |
| D | 2.5-5 mg/kg
BW PO q12-24h (1) 2.5-5 mg/kg BW IM, SC as a loading dose (1) 5 mg/kg BW SC bid (1) 5mg/kg BW IV bid (1) |
| F | 2.5-5
mg/kg BW IM, PO, SC bid (1) |
| G | 2.5-5
mg/kg BW IM, PO, SC bid (1) |
| Gp | 5-10 mg/kg
BW PO (1) |
| H | 5-10 mg/kg
BW PO (1) |
| M | 2.5-5
mg/kg BW IM, PO, SC bid (1) |
| N | 5 mg/kg
BW IM, PO q24h for 5 days (1) |
| R | 2.5-5
mg/kg BW IM, PO, SC bid (1) |
| Rb | 5-10 mg/kg
BW IM, SC bid, repeated injections may lead to necrosis, abscesses
(1) |
| Sh | 2.5-5 mg/kg BW IM, PO, SC bid (1) |
| Sw | 2.5-5 mg/kg BW IM, PO sid (1) |
| C | 0.005-0.01
mg/kg BW SC, IM q12h (1) 0.005-0.01 mg/kg BW IV, SC q8-12h (1) 0.005-0.01 mg/kg BW SC, IM q12h (3) |
| D | 0.01-0.02
mg/kg BW SC q12h (1) |
| F | 0.01-0.03
mg/kg BW IM, IV, SC q8-12h (1) |
| G | 0.1-0.2 mg/kg BW SC q8h (1, 4) |
| Gp | 0.05 mg/kg
BW SC q8-12h (1, 4) |
| H | 0.05 mg/kg
BW SC q8-12h (1) |
| M | 2 mg/kg BW
SC q12h (1) 2.5 mg/kg BW IP q6-8h (1) 0.05-0.1 mg/kg BW SC bid (1) 0.2 mg/100gm BW SC q12h (3) 0.2 mg/100gm BW IP q6-8h (3) 0.05-2.5 mg/kg SC, IP q6-12h (4) |
| N | 0.01 mg/kg
BW IM, IV q12h (1, 4) |
| R | 0.1-0.5
mg/kg BW SC, IV q12h (1) |
| Rb | 0.02-0.05
mg/kg BW SC, IM, IV q8-12h (1) |
| Sh | 0.005-0.01 mg/kg BW IM q4-6h (1) |
| Sw | 0.005-0.01
mg/kg BW IM, IV (1) |
| C | 25-50 mg/kg BW IM, IV, SC q4-8h (1) |
| D | 15-25 mg/kg BW IM, IV, SC q4-8h (1) |
| Gp | 100 mg/kg BW IM bid (1) |
| N | 25 mg/kg BW IM, IV bid for 7-10 days (1) |
| C | Toxic (1) |
| D | 15 mg/kg BW PO q8h (1, 4) |
| M | 300mg/kg BW PO (1) |
| N | 5-10 mg/kg BW PO (1) |
| R | 110-300 mg/kg BW PO (1) |
| C | 11 mg/kg BW PO bid (1) |
| D | 11 mg/kg BW PO bid (1) |
| F | 10 mg/kg BW PO bid (1) |
| Gp | May cause enterotoxic cecitis |
| C | 1 mg/kg BW IV to maximum of 5 mg (1) |
| D | 1 mg/kg BW IV to maximum of 20 mg (1) |
| F | 2 mg/kg BW IM (1, 2, 3) |
| G | 5 mg/kg BW IP (1) |
| Gp | 5 mg/kg
BW IP (1) 2.5 mg/kg BW IP, IM (1) 5 mg/kg BW IP, IM (2) 0.25-0.5 mg/100gm BW IM, IP (3) 3-5 mg/kg BW IM (4) |
| H | 5 mg/kg BW IP (1) |
| M | 5 mg/kg BW IP (1) |
| N | 1 mg/kg
BW IM (1, 2, 3) 1 mg/kg BW IV (1, 3) 0.5 mg/kg BW PO (4) 0.25-0.5 mg/kg BW IM, IV (4) |
| R | 2 mg/kg BW IV (1) |
| Rb | 2 mg/kg BW IV (1) |
| Sh | 0.5-1.5 mg/kg BW IM, IV (1) |
| Sw | 0.5-10 mg/kg BW IM (1) |
| C | 4
mg/kg BW PO q8h (1) |
| D | 4mg/kg
BW PO q8h (1) |
| Gp | 5 mg/kg
BW SC (1) |
| R | 10 mg/kg BW SC (1) |
| Am | Terrestrial Species: 4-5% in anesthetic chamber to effect
(1) |
| C | 3-5% induction; 1.5-1.75% maintenance (4) |
| D | 3-5% induction; 1.5-1.75% maintenance (4) |
| H | 2-5% induction; 0.25-4% maintenance (4) |
| G | 2-5% induction; 0.25-4% maintenance (4) |
| Gp | 2-5% induction; 0.25-4% maintenance (4) |
| M | 2-5% induction; 0.25-4% maintenance (4) |
| R | 2-5% induction; 0.25-4% maintenance (4) |
| Rb | 3-5% induction; 1.5-1.75% maintenance (4) |
| Sw | 4-5% induction; 1-2% maintenance (4) |
USED ALONE IN MAMMALS, KETAMINE IS USUALLY NOT ADAQUATE FOR DEEP ANESTHESIA AND GIVES POOR MUSCLE RELAXATION (1).
| Am | 50-150 mg/kg SC, IM (1) |
| C | 5-20 mg/kg
BW IM (2) 10-20 mg/kg BW POS (2) 10-20 mg/kg BW IM (3, 4) 4-10 mg/kg BW IV (4) |
| D | 5 mg/kg
BW IV – sedation (3) |
| F | 20-30 mg/kg
BW IM (1, 2) 20-35 mg/kg BW IM (1) 10-20 mg/kg BW IM - sedation (3) 25-40 mg/kg BW IM (3) |
| G | 200 mg/kg
BW IM for immobilization (1) |
| Gp | 44 mg/kg
BW IM, atropine recommended (1) 100-200 mg/kg BW IM for immobilization (1) 100 mg/kg BW IM (2) 2.2-4 mg/100gm BW IM - sedation (3) 2.5-4 mg/100gm BW IM (3) 10-20 mg/100gm BW IM, IP (3) 22-64 mg/kg BW IM |
| H | 10-30
mg/100g BW IP(1) |
| M | 44 mg/kg
BW IM for sedation (1) |
| N | 20-25
mg/kg BW IM (1) - Cynomolgus macaque |
| R | 44 mg/kg
BW IM (1) |
| Rb | 44 mg/kg
BW IM (1, 3) |
| Re | Snakes: 88-110 mg/kg BW IM (for 3.6- to 4.5-kg animals) (1) 22-44 mg/kg BW IM (for <0.9-kg animals) (1) 50-130 mg/kg BW IM (1) 50 mg/kg BW IM (2) 50-80 mg/kg BW IM (2) 22-66 mg/kg BW IM – Lasts 72hrs (3) |
| Tortoises
and Turtles: 15-60 mg/kg BW IM (1) |
|
| Tortoise: 20-80 mg/kg BW IM (1) |
|
| Sh | 22-44 mg/kg
BW IM (1, 3) 20 mg/kg BW IM (2) 2 mg/kg BW IV – sedation (3) |
|
|
| Sw | 15-25 mg/kg
BW IM (1) 15-20 mg/kg BW IV (1) 10-15 mg/kg BW IM (2) 20-30 mg/kg BW IM (3) 5-20 mg/kg BW IM (4) |
KETAMINE/ACEPROMAZINE (respectively)
| C | 20
mg/kg and 0.11mg/kg BW IM (1, 2) 22 mg/kg and 0.5 mg/kg BW IM (3) 4-6 mg/kg and 0.1-0.2 mg/kg BW IM (4) |
| D | 10 mg/kg
and 0.1 mg/kg (max 2.5ml) IV (3) 4-6 mg/kg and 0.1-0.2 mg/kg BW IM (4) |
| F | 20-35
mg/kg and 0.2-0.35 mg/kg BW IM, SC (1) |
| G | 75 mg/kg
and 3 mg/kg BW IM (1, 2, 3) |
| Gp | 125 mg/kg
and 5 mg/kg BW IM (1, 2, 3) |
| H | 150 mg/kg
and 5 mg/kg BW IM (1, 2, 3) |
| M | 100 mg/kg
and 2.5 mg/kg BW IM (1) |
| N | 11 mg/kg
and 0.5 mg/kg BW IM (3) |
| R | 75 mg/kg
and 2.5 mg/kg BW IM (1) |
| Rb | 75 mg/kg
and 5 mg/kg BW IM (1) |
| Sw | 22 mg/kg
and 1.1 mg/kg BW IM (2, 3) |
| C | 1.0-2.0 mg/kg and 0.1- 0.2 mg/kg BW IV (4) |
| D | 1 mg/kg and 1 mg/kg BW IV (3) |
| F | 25 mg/kg and 2 mg/kg BW IM (1, 2, 3) |
| G | 50 mg/kg BW IM and 5 mg/kg BW IP (1, 2, 3) |
| Gp | 100mg/kg and 5 mg/kg BW IM (1, 2, 3) |
| H | 70 mg/kg and 2 mg/kg BW IP (1, 2) |
| M | 200 mg/kg BW IM and 5 mg/kg BW IP (1) |
| N | 15 mg/kg and 1 mg/kg BW IM (1, 2, 4) |
| R | 40-80 mg/kg and 5-10 mg/kg BW IP (1) |
| Rb | 25 mg/kg and 5 mg/kg BW IM (1, 2, 3) |
| Sh | 10-15 mg/kg and 2 mg/kg BW IM (2) |
| Sw | 10-15 mg/kg
and 0.5-2 mg/kg BW IM (2) 7 mg/kg and 0.5 mg/kg BW IV – sedation (4) 12-20 mg/kg BW IM AFTER first giving 1-2 mg/kg BW IM (4) |
| C | 22 mg/kg and 1.1mg/kg BW IM (2) |
| D | 5 mg/kg
and 1-2 mg/kg BW IV (2) |
| F | 35 mg/kg
and 5 mg/kg BW IM (1) |
| Gp | 40 mg/kg
BW IM and 5 mg/kg BW SC (1) |
| H | 200 mg/kg and 10 mg/kg BW IP (1, 2, 3) |
| M | 200 mg/kg
and 10 mg/kg BW IP (1) |
| N | 10 mg/kg
and 0.5 mg/kg BW IM (1, 2) |
| R | 40-80
mg/kg and 5-10 mg/kg BW IP (1) |
| Rb | 50 mg/kg
and 10 mg/kg BW IM (1) |
|
|
| Sh | 4 mg/kg and
0.2 mg/kg BW IV (2) 11 mg/kg and 0.22 mg/kg BW IM (3) |
| Sw | 4 mg/kg and 4 mg/kg BW IM (3) |
| Am | 60
mg/kg in dorsal lymph sac – Frogs and Toads (1) |
| C | 30 mg/kg
BW IV to effect (1) |
| D | 30 mg/kg
BW IV to effect (1) |
| F | 36 mg/kg
BW IP
(1) 30 mg/kg BWIV (1) |
| G | 6 mg/100gm
BW IP up to 6mg max (1) |
| Gp | 28 mg/kg
BW IP (1) |
| H | 9 mg/100gm
BW IP, boost with 1.2mg/100gm BW (1) |
| M | 40-85
mg/kg BW IP (1) |
| N | 5-15 mg/kg
BW
IV (1) 20-30 mg/kg BW IV (3) 30-35 mg/kg BW IP (3) |
| R | 30-40
mg/kg BW IP (1) |
| Rb | 28 mg/kg
BW IV,
IP (1) 25-30 mg/kg BW IV (4) |
| Re | 16 mg/kg
BW IC, IP – Turtles (1) |
| Sh | 25-30 mg/kg
BW IV (1) 15-30 mg/kg BW IV, lower dose for castrated animals (1) |
| Sw | 25-35 mg/kg
BW PO (1) 30 mg/kg BW IP (1) 20-30 mg/kg BW IV (1) 20-30 mg/kg BW IV – pigs <45 kg – use with respirator (3) 15 mg/kg BW IV – pigs >45 kg – use with respirator (3) |
| C | 5-8
mg/kg BW IV (2) |
| D | 5-7.5
mg/kg BW IV (2) |
| M | 20-30 mg/kg
BW
IV (1) 26 mg/kg BW IV (1) 12-26 mg/kg BW IV (4) |
| N | 7.5-12.5
mg/kg BW IV (1, 2) |
| R | 10 mg/kg
BW IV (1, 2) 7.5-10 mg/kg BW IV (4) |
| Rb | 7.5-15
mg/kg BW IV (1) |
| Sh | 4-5 mg/kg BW IV (2) |
| Sw | 2.5-3.5 mg/kg BW IV (2, 4) |
| C | 0.2-0.5 mg/kg BW PO tid (1) |
| D | 0.2-0.4 mg/kg
BW SC tid (1) 0.2-0.5 mg/kg BW PO tid (1) 1-2 mg/kg BW/day IV over 24 hr (1) |
| Rb | 0.2-0.5
mg/ml BW PO, SC (1) |
| G | 15 mg/kg BW PO bid (1) |
| Gp | 15 mg/kg BW PO bid (1) |
| H | 15 mg/kg BW PO bid (1) |
| Rb | 15 mg/kg BW PO bid (1) |
| C | 7.5
mg/kg BW
IM (1, 2, 4) 2.2-4.4 mg/kg BW IV (4) |
| D | 7.5 mg/kg BW IM (4) |
| F | 22 mg/kg BW IM (1) |
| G | 60 mg/kg BW IM (1) |
| Gp | 10-30 mg/kg BW IM (1) |
| H | 50-80 mg/kg BW IP (2) |
| M | 80 mg/kg BW IP (2) |
| N | 2-6 mg/kg BW IM (1, 4) |
| R | 20-40 mg/kg BW IP (1, 4) |
| Rb | Not
generally recommended except intranasally, nephrotoxicity can occur. 10-25 mg/kg BW IM (1) 10 mg/kg BW intranasally (no renal compromise) (1) 3 mg/kg BW IM (4) Re 22 mg/kg BW IM – Snakes (1) 10-20 mg/kg BW IM – Snakes (1) |
| Sh | 2.2 mg/ml BW IM (1) |
| Sw | 6.6-11 mg/kg
BW IM following Xylazine 2mg/kg BW IM (1) 6-8 mg/kg BW IM (1, 2) 2-4 mg/kg BW IM (2) 4-6 mg/kg BW IM (4) |
| G | 20-30 mg/kg and 10 mg/kg BW IM, IP (4) |
| H | 30 mg/kg and 10 mg/kg BW IP (1, 2) |
| Rb | 15 mg/kg and 5 mg/kg BW IM (1) |
| Sw | 4.4 mg/kg
and 2.2 mg/kg BW IM (1) 6 mg/kg and 2.2 mg/kg BW IM (1, 4) 2-7 mg/kg and 0.2-1 mg/kg BW IM (1, 2) 2 mg/kg and 2 mg/kg BW IV (4) |