Civitan International Research Center (University-Wide Interdisciplinary Research Center)

Director:  Harald Sontheimer, PhD

Medical Director:  Alan J. Percy, MD

Established:  1989

 

Mission and Demographics

            The mission of the Civitan International Research Center is to conduct basic and applied neurodevelopmental research and to improve the well-being and quality of life for individuals and families affected by mental retardation and developmental disabilities.  The Center currently has 89 associated faculty representing 21 departments and 9 schools at UAB.

Center Research 

            The research, training, and clinical services of the Center are focused on nervous system development and disorders as well as preventing and treating a wide range of developmental disabilities that affect children and families around the world.  Home of the Civitan - Sparks Clinics and Alabama's University Center for Developmental Disabilities Education, Research, and Service (UCEDD), the Center provides a stimulating environment for researchers whose theories and findings may prove useful to one another through multidisciplinary and collaborative efforts.  The Center’s facilities include 60,000 square feet in the Civitan building and 3,000 square feet in the 20th Street Community Health building.

            The Civitan - Sparks Clinics represent the Center’s clinical services division and provide direct clinical services related to developmental disabilities.  The 19 specialty clinics also include specialized equipment for testing procedures in audiology, speech pathology, psychology, dentistry, and optometry.  The Center-based clinics experienced nearly 8,000 client encounters during fiscal year 2005 and more than 17,000 additional encounters took place in community settings throughout Alabama

            The UCEDD works to improve the lives of persons with developmental disabilities and their families so that they may become more fully integrated into their communities and lead productive and independent lives.  Funded by the US government through the Administration on Developmental Disabilities and the Maternal and Child Health Bureau, the UCEDD provides leadership in the field of developmental disabilities to upgrade and broaden the skills of professionals and caregivers to ensure the rights of persons with developmental disabilities.    Nearly 1 in 160 children are diagnosed with autism.  In response the CIRC has chosen Autism as an area of research focus for the next 5-10 years.  New faculty have been recruited to study this puzzling disorder and our current clinical staff have stepped up their research efforts to better understand Autism Spectrum Disorders (ASD) and to help develop treatments and therapy to improve the lives of individuals with ASD.  Center scientists are involved in research collaborations with Baylor School of Medicine, University of California MIND Institute and the University of Alabama. 

            The Center is involved in basic research in collaboration with the Department of Neurobiology.  While the focus of the Department's research is on the molecular and cellular basis of normal structure and function of the nervous system, much of the work addresses major issues in neurological health and disease which are related to the focus of the Center including: epilepsy, brain/spinal cord injury, mental retardation/developmental disorders, perceptual disorders, and learning and memory.

Mental Retardation/Developmental Disabilities Research Center

            The Civitan Center also incorporates the UAB Mental Retardation Research Center (MRRC).  Funded by a grant from the National Institute on Child Health and Human Development, the MRRC includes projects in basic neurosciences, prenatal development, and neurological processes in myelinogenesis.  It also contains administrative, neuroscience, and data analysis support cores.

Center for Glial Biology in Medicine

            In February of 2006 the UAB Board of Trustees approved the formation of a new research center devoted exclusively to the study of glial cells and their role in developmental disabilities, acute injury and related disease of the nervous system.  The Center for Glial Biology in Medicine, the first of its kind in the US has 30 participating faculty that span many departments and schools at UAB.  The administration of the Center and several core research laboratories are housed on the 4th and 5th floor of the CIRC.

Training

Pre- and post-doctoral training take place through the Center in the following disciplines: pediatrics, psychiatry, neurobiology, rehabilitation, physical therapy, occupational therapy, audiology, speech/language pathology, psychology, nutrition, social work, optometry, and dentistry.  The Civitan Center’s Leadership Education in Neurodevelopmental Disorders program currently includes 13 intermediate-term (41-200 hours) and 27 long-term (300 hours or more) students and interns, as well as 3 post-doctoral fellows.  The Department of Neurobiology has 32 pre-doctoral students and 11 post-doctoral fellows.  During the past five years, some 550 Center students and fellows have come from 28 states and 17 countries.

National and International Collaborations

           The Center is also engaged in research in the area of acute traumatic brain and spinal cord injury.  Center scientists in the department of Physical Medicine and Rehabilitation are looking at novel therapies to mitigate the long term disability associated with these types of injury.  In addition, a recent grant award from the Department of Defense will study the effects of explosive percussion waves on the brain that is experienced by servicemen and women in our military.           

            A partnership with PICK (Parents of Infants and Children with Kernicterus) strives to prevent a disability that can result from a breakdown of bilirubin in the blood of newborn children.  The condition can lead to brain damage affecting a child’s ability to maintain posture, coordinate movements, and hear properly.

UAB Functional Neuroimaging Laboratory 

            Our new fMRI facility in the CIRC, began operations April 1, 2007, and is dedicated to research of neurodevelopmental disorders and disabilities.  The centerpiece of the UAB Functional Neuroimaging Laboratory will be a Siemens 3.0 Tesla Allegra head-only MRI scanner.  The short bore of the scanner allows family members or companions to remain with the subject if they are frightened or agitated.  N. Shastry Akella, PhD, Research Assistant Professor in Biomedical Engineering is the Director of the UAB Functional Neuroimaging Lab.

Center Sponsorship

The Civitan Center receives annual support from the Civitan International Foundation, the charitable arm of Civitan International, a volunteer service organization with chapters in 24 countries, committed to helping people with developmental disabilities.  The Foundation contributes toward a multi-year total pledge of $20 million to provide core support for the Center.

 

For more information or clarification, please contact:

            Anne Wailes, Program Director I

Email:  awailes@ uab.edu

Phone:  205-934-8900 or 1-800-822-2472

Facsimile:  205-975-6330

Web Site:  http://www.circ.uab.edu/

 

 

Approved by:  Harald Sontheimer, PhD, Director

Date:  April 21, 2008

 

 

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