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  • How T cell-derived interleukin-22 promotes antibacterial defense of colonic crypts

    How T cell-derived interleukin-22 promotes antibacterial defense of colonic crypts Researchers show how two types of immune cells — one a part of the innate immune system and the other a part of the adaptive immune system — play distinct and indispensable roles in the colon to defend against pathogenic bacteria.

  • Whole-Genome Assembly Improved in Long-Read Sequencing

    Previously updated in 2013, researchers behind the Telomere-to-Telomere Consortium have now published the first complete, gapless sequence of a human genome. It will now replace the reference genome first drafted in 2000 under the original Human Genome Project.

  • Apr. 1, 2022 PowerTalk Seminar Series: Clinical Informatics with Fabricio Kury, MD

    Apr. 1, 2022 PowerTalk Seminar Series: Clinical Informatics with Fabricio Kury, MD Friday, Apr 1 | 10 to 11 a.m. | Zoom Meeting Please join us for the Informatics Institute PowerTalk Seminar Series-Clinical Informatics! “Current Practices and Frontiers in Rule-Based Electronic Phenotyping” Fabricio Kury, MDClinical Data Strategist AbstractElectronic phenotyping is the process of identifying patient subjects for study, as well as their covariates, and is integral to the majority of secondary use cases of electronic health data sets. Rule-based phenotyping, the most common kind, starts from a definition in medical language, and manually produces a computer algorithm to model that definition based on how patient data is expected to exist, if it does. This presentation leverages examples from current phenotyping practice to walk the audience through its work process, and illustrate hindrances found along the way. Discussed topics include practical matters, such as deciphering mismatches in the results between phenotypes, uncovering logical gaps in medical definitions, comparing phenotypes definitions themselves, computing clinical scores from groups of data elements, as well as higher-level matters such as current software tools, and computational complexity in phenotyping.

  • Mar. 25, 2022 PowerTalk Seminar Series: Bioinformatics with Qianqian Song, PhD

    Mar. 25, 2022 PowerTalk Seminar Series: Bioinformatics with Qianqian Song, PhD   Friday, Mar 25, 10 to 11 a.m. | Zoom Meeting Please join us for the Informatics Institute PowerTalk Seminar Series – Bioinformatics! “Data-driven Informatics Research for Precision Oncology” Qianqian Song, PhDAssociate Professor of Cancer BiologyWake Forest School of Medicine

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