Van Meir, Osuka

A previous article published in the Journal of Clinical Investigation titled "N-cadherin upregulation mediates adaptive radioresistance in glioblastoma" has been recommended in Faculty Opinions as special significance in its field by University of Missouri faculty member Alan Parrish, Ph.D. UAB Department of Neurosurgery Professor Erwin G. Van Meir, Ph.D., and Assistant Professor Satoru Osuka, M.D., Ph.D., co-authored this paper in 2021. 

Faculty Opinions is an in-depth directory of the top articles in biology and medicine, as recommended by a Faculty of over 5,000 expert scientists and clinical researchers, assisted by 5,000 associates. Articles are rated, and expert commentaries explain their importance.

"This paper demonstrates that N-cadherin expression mediates radioresistance in glioblastoma. N-cadherin expression is upregulated in surviving cell subpopulations following irradiation. Increased N-cadherin expression was associated with radioresistance in glioma stem cell, while radioresistant glioma stem cells lost their phenotype following CRISPR/Cas9 knockdown of N-cadherin. Mechanistically, the N-cadherin effect may be mediated by the suppression of Wnt/beta-catenin signaling," says Parrish.

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Other authors from UAB are G. Yancey Gillespie, Ph.D., Chaoxi Li, M.D., Christian T. Stackhouse and Christopher D. Willey, M.D. Co-authors from Emory University are Dan Zhu, Zhaobin Zhang and Jeffrey J. Olson. Co-authors from Keio University, Tokyo, Japan, are Oltea Sampetrean and Hideyuki Saya.