UAB COVID-19 CORE (Collaborative Outcomes Research Enterprise) - Scientific Community of Outcomes Researchers

Purpose:

To engage a collaborative working group to coordinate, collate, and facilitate the rigorous and expeditious completion of COVID-19 health services, outcomes and population health studies conducted by interdisciplinary research teams addressing prescient questions germane to the individuals, communities and populations we serve in our city, county, state, and Deep South region.

Functions:
- Collation / Clearinghouse of COVID-19 databases (e.g., health system registries, ADPH surveillance)
- Determination and development of specific COVID-19 cohorts / phenotypes (e.g., testing, ICU)
- Concept Proposal coordination: submission, review, feedback (web based, REDCap platform)
- Identify interdisciplinary investigators to form research teams for ‘approved’ Concept Proposals
- Database / Informatics liaison to generate study specific datasets
- BERD liaison to provide feedback and support for design, data analysis, interpretation and dissemination
- Explore multisite collaborative opportunities for Concept Proposals across the CCTS Partner Network
Leadership

Emily Levitan, ScD
CORE Co-Chair
Co-Director, Center for Outcomes and Effectiveness Research and Education
Associate Professor, Epidemiology
School of Public Health

Michael Mugavero, MD, MHSc
CORE Co-Chair
Co-Director, Center for Outcomes and Effectiveness Research and Education
Director, CCTS Training Academy
Professor, Infectious Diseases
School of Medicine

Becky Reamey, PhD
Program Director, Scientific Community of Outcomes Researchers
Program Director, Center for Clinical and Translational Science (CCTS) Training Academy

Organizational Chart

Advisory Committee

Andrew Butler, MPT, MBA, PhD
Dean, School of Health Professions

James Cimino, MD
Senior Scientist, Informatics Institute
School of Medicine

Paulette Dilworth, PhD
Vice President Diversity, Equity and Inclusion

Craig Hoesley, MD
Professor, Infectious Diseases
School of Medicine

Keith A. (Tony) Jones, MD
Senior Associate Dean
Clinical Affairs

Robert Kimberly, MD
Director, Center for Clinical and Translational Science
Professor of Medicine, Immunology and Immunotherapeutics
School of Medicine

Jeanne Marrazzo, MD
Professor of Medicine, Infectious Disease
School of Medicine

Kristi Menear, PhD
Professor, Department of Human Studies
School of Medicine

Paul Muntner, PhD
Professor and Associate Dean, Epidemiology
School of Public Health

Kenneth Saag, MD
Director, Center for Outcomes and Effectiveness Research and Education
Professor of Medicine, Immunology
School of Medicine

David Schwebel, PhD
University Professor
Associate Dean for Research
College of Arts and Sciences

David Vance, Phd, MGS, MS
Professor and Associate Dean
School of Nursing

Molly Wasko, PhD
Professor and Associate Dean
Collat School of Business
Programmatic Groups: Building the Research Platform

Programmatic groups convene interdisciplinary faculty spanning schools at UAB to define and prioritize existing (for secondary analyses) and desired (for future capture) data elements for inclusion in a shared CORE research platform. These time-limited groups define the data elements initially available and then transition to a dormant phase, with reactivation, as needed, as new data elements come available for addition to the CORE research platform. Programmatic groups are closed and included invited individuals spanning diverse scientific disciplines and Schools at UAB.
Programmatic Working Group 1: Health System Data
Co-Chairs:

James Willig and Matt Wyatt

Members:

Sue Feldman, Craig Hoesley, Anand Iyer, Kierstin Kennedy, Yulia Khodneva, Rachael Lee, Audrey Lloyd, Patricia Patrician, David Redden

Goals:

Define case definitions for cohorts (e.g. testing, PUI, confirmed cases)

Determine harmonized catalog of health systems data elements

Determine structured data elements amenable to query

Determine unstructured data elements requiring abstraction

Develop data management/data coordination procedures
Programmatic Working Group 2: Questionnaire & Patient Reported Outcome Data
Co-Chairs:

Allyson Hall and Faith Fletcher

Members:

Mirjam-Collette Kempf, Merry-Lynn McDonald, Gabrielle Rocque, Patricia Patrician, Libby Van Gerwen

Goals:

Identify potenal questionnaires/validated instruments and Patient Reported Outcomes (PROs) for adjunctive data capture

Determine prioritization for questionnaire and PRO administration

Define timing, frequency and preferred modality of questionnaire and PRO administration
Programmatic Working Group 3: Community & Public Health Data
Co-chairs:

Irfan Asif and Monica Aswani

Members:

Ellen Eaton, Eric Ford, Brandi McCleskey, Becky Reamey

Goals:

Identify and collate sources of COVID-19 community data capture

Liaise with Jefferson County Health Department and Alabama Department of Public Health re: COVID-19 surveillance data capture

Liaise with the City of Birmingham #BHMStrong team re: non-health related data capture germane to COVID-19 (e.g., economic, employment)
Programmatic Working Group 4: Research Coordinating Committee
Co-chairs:

Emily Levitan and Mike Mugavero

Members:

Jeff Foster, Lisa Jackson, Dustin Long, Aadia Rana

Goals:

Determine human subjects and regulatory considerations with IRB

Develop COVID-19 CORE Concept Proposal

Develop procedures for project coordination following concept proposal submission in collaboration with data management/data coordination and BERD (Biostatistics, Epidemiology, Research Design)
Scientific Groups: Conducting Thematic Outcomes Research Studies

Scientific groups convene interdisciplinary investigators with shared interests in thematic areas to vet ideas, hone research questions, build interdisciplinary study teams and facilitate concept proposal submissions. Scientific groups are open to all interested faculty, staff, and students at UAB.

Scientific Working Group 1: Health Disparities

Co-Leaders:

Faith Fletcher, Allyson Hall & Mandy Willig

Join the Health Disparities Working Group:

First Name
Invalid Input

Last Name
Invalid Input

Career Level
Invalid Input

Title:
Invalid Input

Department:
Invalid Input

Email Address
Invalid Input

Captcha(*)

Invalid Input

Scientific Working Group 2: Neurocognition

Co-Leaders:

Richard Kennedy & David Vance

Join the Neurocognition Working Group:

First Name
Invalid Input

Last Name
Invalid Input

Career Level
Invalid Input

Title:
Invalid Input

Department:
Invalid Input

Email Address
Invalid Input

Captcha(*)

Invalid Input

Scientific Working Group 3: Critical Care

Co-leaders:

Sheetal Gandotra, Russell Griffin & Derek Russell

Join the Critical Care Working Group:

First Name
Invalid Input

Last Name
Invalid Input

Career Level
Invalid Input

Title:
Invalid Input

Department:
Invalid Input

Email Address
Invalid Input

Captcha(*)

Invalid Input

Scientific Working Group 4: Financial & Operational Implications

Co-leaders:

Eric Ford, Bunyamin (Ben) Ozaydin & Ferhat Zengul

Join the Financial & Operational Implications Working Group:

First Name
Invalid Input

Last Name
Invalid Input

Career Level
Invalid Input

Title:
Invalid Input

Department:
Invalid Input

Email Address
Invalid Input

Captcha(*)

Invalid Input

Scientific Working Group 5: Chronic Co-morbidities

Co-leaders:

Lyse Norian & Gabrielle Rocque

Join the Chronic Co-morbidities Working Group:

First Name
Invalid Input

Last Name
Invalid Input

Career Level
Invalid Input

Title:
Invalid Input

Department:
Invalid Input

Email Address
Invalid Input

Captcha(*)

Invalid Input

Scientific Working Group 6: Patient Safety & Quality

Co-leaders:

Patricia Patrician

Join the Patient Safety & Quality Working Group:

First Name
Invalid Input

Last Name
Invalid Input

Career Level
Invalid Input

Title:
Invalid Input

Department:
Invalid Input

Email Address
Invalid Input

Captcha(*)

Invalid Input

Scientific Working Group 7: Healthcare Worker Well-being & Satisfaction

Co-leaders:

Greer Burkholder, Crystal Chapman-Lambert, Katherine Meese

Join the Healthcare Worker Well-being & Satisfaction Working Group:

First Name
Invalid Input

Last Name
Invalid Input

Career Level
Invalid Input

Title:
Invalid Input

Department:
Invalid Input

Email Address
Invalid Input

Captcha(*)

Invalid Input

Suggest a new scientific working group:

First Name
Invalid Input

Last Name
Invalid Input

Career Level
Invalid Input

Title:
Invalid Input

Department:
Invalid Input

Email Address
Invalid Input

Please provide a title for your suggested Scientific Working Group:
Invalid Input

Please provide a brief description and list of suggested goals for this Scientific Working Group:
Invalid Input

Captcha(*)

Invalid Input
Process & FAQs
Once a Concept Proposal has been submitted, a member of the CORE team will reach out to schedule a Scientific Gateway Meeting. This is a call with the investigative teamt that includes representatives from Enterprise Data Warehouse (EDW), Clinical/Medical Informatics, CCTS BERD (Biostats, Epi, Research Design) and COERE/outcomes research. The concept proposal will be distributed to this group in advance of the call to facilitate a more informed discussion.

The Scientific Gateway Meeting ultimately leads to a Data Gateway Meeting which is requested by submitting a Data Extraction/Transformation request form. Data Extraction/Transformation requests generate a study specific analysis dataset. Once submitted, a member of the CORE team will reach out to schedule a Data Gateway Meeting. This is a call with the investigative team that includes representatives from Enterprise Data Warehouse (EDW) and Clinical/Medical Informatics. The completed Data Extraction/Transformation request form will be distributed to this group in advance of the call to facilitate a more informed discussion.
Submit a Concept Proposal

Once submitted, a member of the CORE team will reach out to you to schedule a Scientific Gateway Meeting. This is call with your investigative team that will include representatives from Enterprise Data Warehouse (EDW), Clinical/Medical Informatics, CCTS BERD (Biostats, Epi, Research Design) and COERE/outcomes research. Your concept proposal will be distributed to this group in advance of the call to facilitate a more informed discussion.

Lead Investigator:

(Point person who will oversee project, including contact information) Invalid Input

Lead Investigator's Email Address:

Invalid Input

Co-investigator(s):

(Collaborator(s) who will participate in project) Invalid Input

Research question(s):

(Define the question(s) the proposal is designed to address.) Invalid Input

Background:

(Paragraph describing why is this question relevant? What unique perspective does this proposal bring?) Invalid Input

Will you be requesting biospecimen samples for this project?

YesNo Invalid Input

Study sample:

(Detailed eligibility criteria that define participation in the proposed study?) Invalid Input

Outcome variable(s):

(Primary variable(s) related to the research question. Ex: Inpatient hospital survival vs. death) Invalid Input

Confounding & control variable(s):

**Please include ALL requested confounding & control variables** (Variables that may be associated with the primary predictor and outcome variables as supported by clinical or public health practice and the literature that should be included in statistical models) Invalid Input

Statistical analysis:

(Statistical / analytical tests to be completed including descriptive, unadjusted and adjusted analyses) Invalid Input

Limitations:

(List limitations to the proposed study) Invalid Input

Type of journal:

(Target journal and / or focus. Ex: internal medicine, public health) Invalid Input

Literature cited:

Include articles related to topic, emphasizing the relevance of the proposed research) Invalid Input

(*)

Invalid Input

Submit

Request Data Extraction/Transformation

Request Data Extraction/Transformation to generate a study specific analysis dataset. Once submitted, a member of the CORE team will reach out to you to schedule a Data Gateway Meeting. This is call with your investigative team that will include representatives from Enterprise Data Warehouse (EDW) and Clinical/Medical Informatics. Your Data Extraction/Transformation Request will be distributed to this group in advance of the call to facilitate a more informed discussion.

*Please note the following:

1. Once we have completed the data request and mappings, depending on the complexity and existing work queue we will provide you with an estimated date of completion. Please keep in mind that our team serves multiple investigators and interests within the institution.

2. Expect to be contacted within 2 business days from form submission for clarification.

3. Once you receive data, please review carefully and ensure that it meets your needs. You will have 3 business days to contact us for clarifications/changes to request. Requests for changes received after this time period will result in your query returning to the bottom of the New Request queue.

**Data requests should NOT include protected health information (PHI) such as names, MRNs, birthdates, etc.

Project/Grant/Study Title:

Invalid Input

Requesting person/entity:

Invalid Input

Requestor's Email Address

Invalid Input

Research Question(s)/Objective(s):

(Define the question(s)/objective(s) the project is designed to address.) Invalid Input

Purpose of request: (feasibility, analysis, grant submission, etc.)

(Feasibility, analysis, grant submission, etc.) Invalid Input

Has this request been run before? If yes, please provide the date.

Invalid Input

Clearly define population for this data request:

Invalid Input

Type of journal:

(Target journal and / or focus. Ex: internal medicine, public health) Invalid Input

Specify and define period for all requested variables:

Invalid Input
- Sheet 1: Variables that appear once in a dataset (demographics and patient related data as well as any variables you are calculating to be one indicator per person) - All subsequent Sheets: Patient identifier/FIN, Encounter or NA/Requested Variable Variables that appear more than once

Please select your preferred file format for data delivery:

.csv.xlsx Invalid Input

Please indicate your preferred mechanism for data delivery:

Invalid Input

Please provide a copy of your HSP submission as well your IRB approval letter:

Invalid Input

Comments/clarifications:

Invalid Input

I am not a robot(*)

Invalid Input
Your Name:

Invalid Input

Your Email:

Invalid Input

Subject:

Invalid Input

Message:

Invalid Input

(*)

Invalid Input

Purpose:

Functions:

Leadership

Organizational Chart

Advisory Committee

Programmatic Groups: Building the Research Platform

Programmatic Working Group 1: Health System Data

Programmatic Working Group 2: Questionnaire & Patient Reported Outcome Data

Programmatic Working Group 3: Community & Public Health Data

Programmatic Working Group 4: Research Coordinating Committee

Scientific Groups: Conducting Thematic Outcomes Research Studies

Scientific Working Group 1: Health Disparities

Co-Leaders:

Join the Health Disparities Working Group:

Scientific Working Group 2: Neurocognition

Co-Leaders:

Join the Neurocognition Working Group:

Scientific Working Group 3: Critical Care

Co-leaders:

Join the Critical Care Working Group:

Scientific Working Group 4: Financial & Operational Implications

Co-leaders:

Join the Financial & Operational Implications Working Group:

Scientific Working Group 5: Chronic Co-morbidities

Co-leaders:

Join the Chronic Co-morbidities Working Group:

Scientific Working Group 6: Patient Safety & Quality

Co-leaders:

Join the Patient Safety & Quality Working Group:

Scientific Working Group 7: Healthcare Worker Well-being & Satisfaction

Co-leaders:

Join the Healthcare Worker Well-being & Satisfaction Working Group:

Suggest a new scientific working group:

Process & FAQs

Submit a Concept Proposal

Request Data Extraction/Transformation