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Program in Structural Biology
Heersink School of Medicine
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Promoting cutting-edge research in structural biology through research, education and technology development.

The UAB Structural Biology Program (SBP) brings together investigators focused on determining structures of macromolecules, and macromolecular complexes, to understand how cells, virus and bacteria function at the molecular level. Program members are committed to using structure-guided discoveries to treat cancer, infectious disease and autoimmunity.


UAB-SERCAT STRUCTURAL BIOLOGY SYMPOSIUM

Molecular Insights into Human Disease
When: March 14th and 15th
Where: Edge of Chaos
Click here for more information.

The Unifying Theme of the Structural Biology Program is 3-Dimensional Structure.

The Unifying Theme of the Structural Biology Program is 3-Dimensional Structure.

SBP faculty use core technologies of X-ray Crystallography (X-ray), Nuclear Magnetic Resonance (NMR) and Cryo-Electron Microscopy (Cryo-EM) to elucidate 3D structures of macromolecules that impact human health. The diverse problems under investigation include bacterial pathogenesis, virus assembly and replication, and fundamental cell processes that impact cancer, vaccine development and autoimmune disease.

SBP Faculty Elucidate Structure-Based Molecular Mechanisms.

SBP Faculty Elucidate Structure-Based Molecular Mechanisms.

There is a difference between making an observation and understanding the molecular mechanism behind that observation. Elucidating 3D structure information is only the beginning of scientific discovery. SBP faculty collaborate to apply multiple structural techniques (X-ray, NMR, Cryo-EM, and structural mass spectrometry) and cellular assays to define how macromolecules perform their molecular functions.

 
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