Our structural biology faculty members are a diverse group, housed in many departments. The common theme of the structural biology faculty members is the recognition of the central importance of the gaining and utilizing structural information to understand biological function at the molecular level.
The systems under study include proteins involved in the immune response, ion and metabolite transport, cell-cell recognition, multidrug resistance, virus-host interactions and signal transduction protein folding, protein-nucleic acid interactions and more.
In addition, a number of our faculty utilize structural data to design novel drugs for a variety of infectious and chronic diseases including influenza and HIV, bacterial host interactions, methicillin-resistant Staphylococcus aureus (MRSA), anthrax, tularemia and other pathogenic bacteria, oral bacteria that cause gum and tooth diseases, cystic fibrosis, Parkinson’s and Alzheimer’s diseases, atherosclerosis, diabetes and several different cancers (i.e. prostate, colon, breast and lung cancer).
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Structure/function of membrane
proteins, crystallography scaffolds, structure-based drug design, nanoprobes
mass spectrometry, crystallins, bile acid acyltransferase
Protein Structural Cooperativity and Energetics, Biophysics, Antibacterial
Drug Design and Medicinal Chemistry, Biodefense, Molecular Modeling
Protein structure based drug discovery, Host pathogen interaction, Vaccine design
X-ray Crystallography, Dental caries, bacterial surface proteins, Enzymes
|Larry J. DeLucas
membrane protein structure-function relationships, cystic fibrosis transmembrane regulator, X-ray crystallography
Virus Assembly, Cryo-Electron Microscopy
Protein crystallography, molecular mechanisms of cell signaling, metabolic disease
Protein/nucleic Acid Interactions, Intercalating Agents, NMR, Biophysics
Viral transcription and replication, capsid structure
Biological Nanomaterials, Polymer Chemistry
Proteomics of Dementia, Protein Oxidation, Mass Spectrometry
|N. Rama Krishna
Protein Structural Biology, Protein-Ligand Interactions, High-Field NMR Spectroscopy, NMR Methodology
Protein Machines, Motor Proteins, Chaperone/Protease Systems, Biophysics
Virus structure, antiviral drugs, X-ray crystallography
|James A. Mobley
Molecular Biophysics, Drug-protein Interactions, Conformationally Constrained Retinoids
|James C. Patterson
Computational Inorganic Chemistry, Computational Biophysics
|Peter E. Prevelige
Virus assembly, Bio-inspired Nanoparticles, Mass Spectrometry
|Jamil S. Saad
HIV-host interactions, NMR, protein-protein and protein-lipid interactions
|Jere Segrest||Bingdong Sha
Molecular Chaperones, Unfolded Protein Response, Mitochondrial Translocons
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Computational biology, cancer biology, cell adhesion and focal adhesion disassembly
Microbial Pathogenicity, Macromolecular Structure/Function, X-ray Crystallography
|Tim M. Townes|
|Dmitry Vassylyev||Sadanandan Velu
Structure Based Drug Design, Anti-cancer Agents, Anti-infective Agents.
Photochemistry, carbohydrate chemistry, organic synthesis, photo responsive materials