Assistant Professor

Research Interests
primary hyperoxaluria, oxalate endogenous synthesis, calcium oxalate kidney stones, inherited metabolic disorders

Biography

Dr. Fargue’s main research interest is in the pathophysiology of inherited calcium oxalate stone disease, the primary hyperoxaluria (PH). As a clinician in France, Dr. Fargue conducted studies on patients with primary hyperoxaluria type 1 focusing on genotype/phenotype correlations in PH1 and evaluation of treatment in children with PH1. She pursued a PhD in the UK, focusing on alanine glyoxylate aminotransferase (AGT), the enzyme deficient in PH1. She determined how several PH mutations resulted in mitochondrial mistargeting and that pyridoxine, the cofactor of AGT acts both as a chaperone to minimize the mistargeting and stability and as a prosthetic to increase the activity of the enzyme. As a postdoctoral fellow at UAB she studied the effect of the metabolism of glycolate, a precursor of oxalate, in a cell model. She also collaborated on projects aimed at elucidating some of the mechanisms of endogenous oxalate synthesis, notably examining the role of hydroxyproline as a source, in human and model system studies.

Education

Graduate
University College London, Ph.D.

Medical School
Universite Claude Bernard Lyon I, Lyon, France

Postdoctoral Training
University of Alabama at Birmingham

Fellowship
Universite Claude Bernard Lyon I, Lyon, France
Pediatric Nephrology 

Awards and Honors

K01 NIH/NIDDK Mentored Scientist Development Award, 2017-2022
Faculty Development, University of Alabama at Birmingham, 2016
Research Scholarship, American Urological Association/Urology Care Foundation, 2014
Graduate Scholarship, French Society of Nephrology, 2008

Society Memberships

American Society of Nephrology
American Society of Urology
American Physiological Society
French Society of Pediatric Nephrology
OxalEurope

Contact Information

Location
848 Kaul Genetics Building
705 20th Street South

Email: sfargue@uab.edu