News

UAB School of Engineering and Medicine
Weekly Seminar
Janusz Kabarowski and SteveBarnes
1:25 pm – 2:15 pm, Friday, October 27, 2017
Heritage Hall – Room 125

Stephen Barnes, Ph.D.

Professor of Pharmacology and Toxicology, Biochemistry and Molecular Genetics, Environmental Health Sciences, and Vision Sciences
Director, Targeted Metabolomics and Proteomics Laboratory
Senior Scientist, UAB Comprehensive Cancer Center

“Metabolomics and engineering – a two-way process”

As for many other areas of science, bioanalysis is built on the principles of physics and its application to physical processes and the engineering needed to make it better/faster/cheaper. Chromatographic separation of biological analytes is no exception - it began over a century ago in the separation of plant pigments, and has moved to concepts of phase partition (and a Nobel Prize in 1952) to GC and LC and is combined with all sorts of detection systems (another Nobel Prize in 2002). By identifying critical steps in metabolism associated with disease identified with metabolomics, geneticists are applying gene therapy as clinical treatments. The same principles can be applied to organisms that can be engineered make either unique compounds with complex chiral chemistry, or large amounts of chemicals suitable as feedstocks. Engineering and science is now catching up with yeasts and the wine industry that figured out how to this before the advent of systematic bioanalytical science.

Read Flyer.

Teaching metabolomics: a UAB outreach to researchers in sub-Saharan Africa

by Jeff Hansen
May 31, 2016

Mali

For the last 10 weeks, Stephen Barnes, Ph.D., University of Alabama at Birmingham, has taught a group of master’s degree students at a university in the land-locked African nation of Mali. His outreach — via two hours of video conferencing each day and a lot of class material preparation — came at the request of the National Institute of Allergy and Infectious Diseases, to help NIAID create a cadre of bioinformatics researchers at one of the ground zeros for the deadly infectious disease malaria.

Read more at UAB News.

UAB Tissue Imaging Mass Spectrometry detects early lipid changes in acute kidney injury

by Jeff Hansen
March 23, 2016

Janusz Kabarowski and SteveBarnes

University of Alabama at Birmingham researchers have made a microscopic snapshot of the early renal lipid changes in acute kidney injury, using a laser-scanning method called MALDI tissue imaging to localize the changes.

These disease-model results, recently published in American Journal of Physiology’s Renal Physiology, show an example of the power of MALDI tissue imaging. MALDI tissue imaging is now available at UAB, and it will be able to aid basic and clinical biomedical research across the campus, said corresponding author Janusz Kabarowski, Ph.D., associate professor of microbiology.

Read more at UAB News.

Interdisciplinary UAB researchers collaborate to establish new imaging method

by Jim Bakken
January 31, 2014

Janusz Kabarowski and Steve Barnes

An interdisciplinary collaboration at the University of Alabama at Birmingham recently established a research method that has expanded the institution’s already robust capacity for discovery, addressing a need that will aid in critical initiatives addressing a variety of diseases including cancer, chronic inflammatory autoimmune diseases and age-related degenerative diseases.

The matrix-assisted laser desorption/ionization imaging mass spectrometry, or MALDI-IMS, method is a powerful tool for investigating the distribution of molecules within biological systems through the direct analysis of thin tissue sections.

Read more at UAB News.

Barnes selected 2012 UAB Distinguished Faculty Lecturer

September 17, 2012

Steve Barnes

Stephen Barnes, Ph.D., a London native, still remembers how tough times were in post-World War II England. The fighting had devastated the country’s economy, and because resources were not available to expand food production and imports, rationing was common.

“We had rationing of things like sugar and butter until I was 10 years old,” says Barnes, a UAB professor of Pharmacology & Toxicology. “That was the world we knew.”

Children like Barnes were expected to get an education and make money to help get the country back on track. Barnes figured that, like many of England’s youth, he would wind up in industry. But his applied chemistry degree and industrial training instead steered him into the area of research, where he eventually worked under the tutelage of Nobel Laureate Sir Ernst Chain, the co-discoverer of penicillin. There he began using a form of metabolomics, now very popular in modern biomedical research.

Read more at UAB News.

UAB professor attains high honor in nutrition world

by Jim Bakken
April 02, 2012

Steve Barnes

Stephen Barnes, Ph.D., professor of pharmacology and toxicology in the UAB School of Medicine, has been elected as a member of the American Society for Nutrition’s Fellows Class of 2012. Induction into this program is the highest honor the ASN bestows to recognize scientists who have had distinguished careers in the field of nutrition and are age 65 or older.

Barnes, who holds several additional appointments throughout the UAB campus, was nominated for this honor by the UAB Nutrition and Obesity Research Center, where he serves as senior scientist.

Fellows will be recognized during the ASN Awards Ceremony on Sunday, April 22, 2012.

Read more at UAB News.