External Radiation Therapies : EBRT : Total Skin Irradiation (TSI); aka “TSEI” or “TSEB”

Total Skin Irradiation (TSI), and also referred to as TSEI or TSEB, is an External Beam Radiotherapy (EBRT). This treatment therapy uses electrons directed at the entire surface of the body. The radiation goes into the outer layers of the skin, but does not go deeper into tissues and organs below the skin. It is often used to treat cutaneous T-cell lymphoma. If detected early, it can result in the disappearance of any signs or symptoms of the disease.

Body Sites Whole Body
Location HSROC
Therapeutic Technique EBRT
Radioactive Source Electrons
Equipment Linear Accelerator
Method of Delivery External

For more information, please view the following websites:


  • Radiation Treatment Therapy
    Radiation treatment therapies that utilize radioactive sources are called radiotherapies, or radiation therapy. These sources use high-energy radiation from x-rays, gamma rays, neutrons, protons, and other sources, to kill cancer cells and shrink tumors. Radiation damages both cancer cells and normal cells by damaging their genetic material, but normal cells are able to repair themselves and resume proper function. Because of the powerful properties of radiation, proper targeting of cancer cells is essential. Treatment therapies offered at UAB can be administered either externally or internally. External radiotherapies emit radiation from a source outside the body via a machine and include “External Beam Radiation Therapy (EBRT)” and “stereotactic radiosurgery” procedures. Internal radiotherapies place radioactive materials inside the body. They may be placed in the body near cancer cells, using “brachytherapy”, or they inject or infuse a radiolabeled substance into the body via “Radioisotope Therapy (RIT)”. Radiation therapy may be used alone or in combination with chemotherapy or surgery.
  • EBRT
    EBRT is an acronym for External Beam Radiation Therapy. It is a group of externally-administered radiation therapy treatments that deliver radiation to the patient via a linear accelerator. Radiation treatment therapies in the EBRT group include IGRT (Rapid Arc, Tomotherapy), IMRT, 3D Conformal Radiation Thearapy (3D CRT), Superficial, Total Skin Irradiation (TSI), and Total Body Irradiation (TBI).