Discovery on cross-talk among cancer cells hailed as best paper

sandersonUAB research demonstrating the role of heparanase in regulating exosomes has been selected among the “Best of 2013” by The Journal of Biological Chemistry.

The paper, "Heparanase Regulates Secretion, Composition and Function of Tumor Cell-derived Exosomes," was chosen as the best paper in the Glycobiology and Extracellular Matrices category.

A team led by Ralph D. Sanderson, Ph.D., UAB Endowed Professor of Cancer Pathobiology, revealed that heparanase, an enzyme associated with tumor growth and metastasis, increased secretion of exosomes — tiny particles released by cells that interact with other cells.

“This is a way in which tumor cells talk to each other,” said Sanderson, senior scientist in the UAB Comprehensive Cancer Center. More so, tumor cells rely on exosomes to communicate with their environment as they grow and spread.

“Our studies provide the first evidence that heparanase can regulate exosomes — promoting tumor-host cross-talk and enhancing aggressive tumor behavior,” Sanderson said.

The UAB team now is working to design and test new heparanase-inhibitors that will shut down exosome-mediated communication and tumor growth.

Additional Info

  • Kennedy is helping transfer students start strong — at UAB and across Alabama

    Collat’s Karen Kennedy, Ph.D., and the Alabama Association for Higher Education in Business have worked to streamline the transfer process from two- to four-year schools. 

    posted 3 days ago 195 views
  • UAB salutes Women Who Innovate
    During Women’s History Month, meet one woman each weekday who is redefining the problem as part of pursuing a new solution. Some may be familiar, and others may be new to you. All set an example of excellence. Visit here through March 31 to meet them.
    posted 3 days ago 370 views
  • UAB salutes Women Who Inspire

    During Women’s History Month, meet one woman each weekday who encourage us to look at things differently. Some may be familiar, and others may be new to you. All set an example of excellence. Visit here March 20-24 to meet them.

    posted 10 days ago 2381 views
  • UAB salutes Women Who Lead
    During Women’s History Month, meet one woman each weekday who have the reins of some of our most important missions. Some may be familiar, and others may be new to you. All set an example of excellence. Visit here March 13-17 to meet them.
    posted 17 days ago 3902 views
  • UAB salutes Women Who Serve
    During Women’s History Month, meet one woman each weekday who is working to build a better future. Some may be familiar, and others may be new to you. All set an example of excellence. Visit here March 6-10 to meet Women Who Serve.
    posted 24 days ago 1759 views
  • UAB salutes Women Who Discover
    During Women’s History Month, meet one woman each weekday who is working to build a better future. Some may be familiar, and others may be new to you. All set an example of excellence. We begin March 1-3 with Women Who Discover.
    posted a while back 1760 views
  • Baker works tirelessly to improve care for the elderly

    Natalie Baker’s professional service helps ensure concerns about patient care are translated to competencies in the classroom.

    posted a while back 1594 views
  • Feb. 3 is last day to nominate an outstanding woman

    Join us in recognizing their efforts by nominating an outstanding woman student, postdoc, faculty member, administrator, staff member and community member.  Nominations are due by 5 p.m. Feb. 3. 

    posted a while back 1894 views
  • Nominate a Diversity Champion by Dec. 22

    The annual award recognizes employees, students and organizations that have helped create a more culturally diverse, inclusive university community through their achievements.

    posted a while back 2394 views
  • Armstrong never tires of of saying ‘Thank you’

    Melanie Armstrong, assistant director for Stewardship and Donor Relations, is UAB’s Employee of the Month for March.

    posted a while back 5062 views