Research

Ongoing basic science research within the division can be partitioned into various thematic programs - basic electrophysiology, cardiac remodeling, cardiometabolic disease and inflammation. Our researchers within these themes are highly collaborative and innovative.

Research within each of these themes include:

Basic Electrophysiology

Interdisciplinary studies at the UAB Cardiac Rhythm Management Lab Laboratory (CRML) involve the interaction and collaboration of investigators in the electrophysiology laboratory and surgical operating room. Results from these studies have led to and continue to lead to new devices and new therapeutic strategies to control and cure these arrhythmias in patients.

Cardiac Remodeling

Our Cardiac Remodeling researchers are involved in:
  • Left Ventricular remodeling during mitral regurgitation and volume and pressure overload as well as myocardial infarction
  • Pathophysiological, cellular, and molecular mechanisms of left ventricular remodeling, dysfunction, and repair in heart failure
  • Role of cardiac mesenchymal stem cells during remodeling
  • Development of novel cell-based technologies for therapeutic intervention

Cardiometabolic Disease

Our Cardiometabolic Disease researchers are involved in:
  • Role of mitochondrial dysfunction in the pathogenisis of cardiomyopathy and arrhythmias and contractile dysfunction of the heart
  • Exercise effects of mitochondrial function in cardiac and skeletal muscle
  • Circadian regulation of cardiac metabolism
  • Autophagy-dependent cardioprotection in ischemia/reperfusion injury

Inflammation

The Inflammation team is currently focusing on:
  • Role of regulatory T-lymphocytes, neutrophils and macrophages
  • Influence of IL10 on fibroblast progenitor cells and cardiac fibrosis
  • Impact of oxidation on HDL function, apolipoprotein mimetic peptides, and inflammation-induced vascular injury
  • Coupling of vascular inflammation by Acetylated Proline-Glycine-Proline
  • Resolution of inflammation following adverse cardiac events