The Center for Injury Science, founded in 1999, conducts research to promote injury prevention and to improve trauma care. Our mission is to improve outcomes from injury at all stages of care, from the prehospital setting through to resuscitation, acute care and rehabilitation.

Our approach is cross-cutting and multidisciplinary. We support research across UAB and have experience working with the following departments:

  • Anesthesiology 
  • Cardiology 
  •  Emergency Medicine
  •  Infectious Diseases
  • Neurology
  •  Neurosurgery
  •  Pediatric Nephrology
  •  Physical Medicine
  •  Radiology
  •  Surgery

The center is comprised of four research units: the Clinical Trials Unit, the Trauma Care Delivery Research Unit and the Basic Science and Translational Research Unit.

Project Highlight:

PhoXstat Trial

This study uses a novel product called XSTAT. It has been used in the military setting to control bleeding in wounds on the battlefield. The purpose of this study is to see whether XSTAT can be formally studied in a civilian EMS system. If this small study shows that XSTAT might be helpful in this setting, we will conduct a larger study to evaluate whether XSTAT makes a difference to patients’ outcomes.

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Complete Project Listing:

Preclinical identification of patients at high risk for developing in-hospital sepsis

A prospective observational trial using a novel biomarker (CNA Diagnostics Inc.) based on circulating cell-free DNA (cfDNA) in the blood stream to identify patients who are likely to develop sepsis within the next 120 hours.

CORNET Clinical Registry: Characterizing Patient Populations, Interventions and Outcomes in the Cleft Outcomes Research Network (CORNET)

To understand the variability, progression, and current treatment practices for CP+L, to better guideand assess therapeutic intervention; and to provide data necessary for hypothesis generation and study design for studies under development by the CORNET.

Non-Invasive Monitoring of Traumatic Brain Injury Progression using the Infrascanner

To evaluate the feasibility of hourly Infrascanner use in TBI patients and the devices ability to detect enlargement of intracranial hematomas and avoiding routine repeat CT scans in patients with mild or moderately severe traumatic brain injuries.

A Multi-Center Prospective Comparison of Intracorporeal and Extracorporeal Anastomoses for Minimally Invasive Right Colectomy

To compare intracorporeal and extracorporeal anastomosis in right colectomy procedures performed for benign or malignant disease using a robotic or laparoscopic approach.

Endothelial Glycocalyx Dysfunction in Trauma

Observation study designed to collect blood samples to evaluate the role of heparanse and endothelial glycocalyx disruption and the evaluate the association with outcomes among patients with hemorrhagic shock.

Adolescent Bariatrics: Assessing Health Benefits and Risks

To study obese adolescents who are undergoing weight loss surgery with regard to weight, health and emotional changes and quality of life.

Trauma Resuscitation with Group O Whole Blood Or Products - Planning Grant

To mature the statistical design of the TROOP trial, and to develop the research infrastructure required to carry out the trial

Reversing the Endotheliopathy of Infection with COVID-19

To evaluate the safety, clinical outcomes of plasma-based resuscitation in patients with COVID-19 and evaluate a range of biomarkers, which could help to explain mechanistic aspects of the role of plasma in patients with COVID-19.

Restoration of Endothelial Integrity after Traumatic Brain Injury

To evaluate the safety and feasibility of conducting a RCT of plasma-based resuscitation in patients with isolated traumatic brain injuries, and the identify endpoints and biomarkers which could help to explain mechanistic aspects of the role of plasma in patients with traumatic brain injuries.

Trauma Resuscitation with Group O Whole Blood Or Products

A multicenter clinical trial (TROOP) comparing whole blood vs conventional separated component blood in the resuscitation of traumatic hemorrhagic shock.

Management of Acute Appendicitis and Cholecystitis During the COVID-19 Pandemic: An EAST Multicenter Contemporaneous Cohort Study

To evaluate the management of acute appendicitis and cholecystitis among all adult patients (COVID-positive, -negative, and -unknown) during the COVID-19 pandemic and compare to management prior to and after this period.

Aortic Occlusion for Resuscitation in Trauma and Acute Care Surgery registry

The American Association for the Surgery of Trauma Aortic Occlusion for Resuscitation in Trauma and Acute Care Surgery registry prospectively identified trauma patients requiring AO from eight ACS Level 1 centers.

Evaluation of a Novel Hemostatic Agent in Junctional Trauma

To evaluate the feasibility of conducting a randomized clinical trial of the XSTAT® device, in the prehospital setting.

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Pre-operative Regional Nerve Block to Decrease Acute and Chronic Post-Operative Pain and Narcotic Use following Mastectomy

To evaluate the effectiveness of pre-operative nerve block in managing short- and long-term post-mastectomy pain.

Reducing Exsanguination Via In-Vivo Expandable Foam

To study whether ResQFoam can help slow or stop severe internal bleeding in the abdomen while the patient is being brought in for surgery.

Strategy to Avoid Excessive Oxygen for Critically Ill Burn Patients

To determine the feasibility, safety, and effectiveness of the targeted normoxia approach to conserve oxygen and improve clinical outcomes in critically injured patients.

Strategy to Avoid Excessive Oxygen for Critically Ill Trauma Patients

To determine the feasibility, safety, and effectiveness of the targeted normoxia approach to conserve oxygen and improve clinical outcomes in critically injured patients.

Embolization in Splenic Trauma

A prospective, randomized, pilot study to demonstrate the feasibility of such a trial and evaluate clinical outcomes such as splenic preservation, technical success, complications, and costs of using coils vs. plugs for pSAE in the setting of trauma

Embolization in Splenic Trauma, A multicenter RCT

A multicenter RCT to evaluate clinical outcomes such as splenic preservation, technical success, complications, and costs of using coils vs. plugs for pSAE in the setting of trauma

Evaluation of a ketogenic diet for improvement of neurological recovery in individuals with acute spinal cord injury

Test the safety and feasibility of a ketogenic diet intervention in the acute stages of spinal cord injury, to assess the effects of a KD on neurological recovery, and identify potential serum biomarkers associated with KD-induced changes in neurological recovery.

A Multicenter Prospective Observational Study for the Assessment of Urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) to Predict Acute Kidney Injury (AKI) in children receiving Multiple Nephrotoxic Medications

The goal of this study is to assess if daily urine biomarker NGAL can replace daily serum creatinine measurements in children as the marker of choice in the epidemic of nephrotoxic medication (NTMx) exposure as a cause of acute kidney injury (AKI).

Caroid And Veterbral Artery Injury Study

Randomized clinical trial of Blunt Cerebrovascular Injury

Emergency Medical Stroke Assessment Tool

To validate a simple scale used to identify patients with prehospital stroke with large vessel occlusion (LVO), without losing sensitivity for other stroke types.

Testing of Identification Markers for strokE (TIME)

This study aims to evaluate the diagnostic performance (e.g. sensitivity, specificity, accuracy, NPV, PPV) of a panel of blood biomarkers, in conjunction with clinical data, for the identification of large vessel occlusion ischemic stroke subtype. This study will allow the identification and evaluation of a final panel of biomarkers and will prompt the development of a test for stroke diagnosis in the ambulance.

COVID-19 Enterprise Biorepository and Data Registry

Institutionwie Biorepository and Data Registry of known positive COVID 19 patients

Longitudinal Assessment of Port-Traumatic Syndromes

To identify and characterize the trajectories of the most common trauma-induced adverse posttraumatic neuropsychiatric sequelae.

Bougie or Stylet In Patients Undergoing Intubation Emergently

A multi-center randomized trial to compare first-attempt bougie use versus endotracheal tube with stylet use for tracheal intubation of critically ill adults in the ED and ICU.

Distinguish Respiratory Underlying Pathogen associated host response in Acute Respiratory Infection: An Evaluation of FebriDx POC Test

To determine the accuracy of the FebriDx® test at identifying an immune response consistent with a viral and/or bacterial infection in patients presenting with a measured fever or recent history of measured fever (in the last 3 days) and show clinical signs and symptoms of an acute respiratory infection.

ED Use of Buprenorphine for the Treatment of Acute Opioid Withdrawal

Initiating Medication Assisted Treatment of Opioid Addiction in the Emergency Department: The ED MAT Protocol

Using Short Stay Units Instead of Routine Admission to Improve Patient Centered Health Outcomes for AHF Patients.

A multi-center, RCT to test whether Short Stay Unit AHF management for less than 24 hours increases DAOOH and QoL compared to usual care, defined as in-hospital management.

COVID Evaluation of Risk for Emergency Departments (COVERED)

A multicenter observational enrolled-cohort surveillance to capture the risk of community transmission and transmission between healthcare providers in the work environment.

Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (ICECAP)

A multicenter, randomized, adaptive allocation clinical trial to determine if increasing durations of induced hypothermia are associated with an increasing rate of good neurological outcomes and to identify the optimal duration of induced hypothermia for neuroprotection in comatose survivors of cardiac arrest.

Shared Decision Making for Stroke Prevention in Atrial Fibrillaiton

The goal of this study is to determine the extent to which the Anticoagulation Choice tool promotes shared decision making and its impact on anticoagulation use and adherence versus standard care in patients with nonvalvular atrial fibrillation.

Randomized Evaluation of Decision Support Interventions for Atrial Fibrillation

To determine what type of “decision aid” will be most helpful for patients with atrial fibrillation (AF) who are facing complicated decisions about medical care for stroke prevention.

The Biosonographic Index

A Novel Index for the Early Detection of Acute Kidney Injury A􏰁er Vascular Surgery – An Exploratory Study

Coagulopathy and Nosocomial Pneumonia After Severe Trauma

To determine the role of coagulation abnormalities and the development of ventilator acquired pneumonia (nosocomial lung infection) after severe trauma.