Associate Professor
Division of Preventive Medicine

Contact Information:

Medical Towers 641
1717 11th Avenue South
Birmingham, Alabama 35205
Phone: (205) 975-7131
Fax: (205) 934-4262

Research Interests

  • Informatics services for high throughput data including microarray and next generation sequencing (NGS)
  • Integration of Medical Informatics and Bioinformatics through data mining and information system development
  • Application of gene expression profiles for personalized medicine

Educational Background

  • UAB, MS Health Informatics, Birmingham, AL, USA, 2002
  • Mount Sinai -NYU Medical Center, PhD Biomedical Sciences, NY, USA, 1999
  • Bethune Medical University, MD, Changchun, China, 1986

Professional Activities

  • American Society of Gene Therapy (ASGT)
  • American Medical Informatics Association (AMIA)

Selected Recent Publications

  • Ludwig MR, Kojima K, Bowersock GJ, Chen D, Jhala NC, Buchsbaum DJ, Grizzle WE, Klug CA, Mobley JA. Surveying the serologic proteome in a tissue specific kras(G12D) knockin mouse model of pancreatic cancer. Proteomics. 2016 Feb;16(3):516-31. PMID: 26572242.
  • Gu Y, Jones AE, Yang W, Liu S, Dai Q, Liu Y, Swindle CS, Zhou D, Zhang Z, Ryan TM, Townes TM, Klug CA, Chen D, Wang H. The histone H2A deubiquitinase Usp16 regulates hematopoiesis and hematopoietic stem cell function. Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):E51-60. PMID: 26699484; PMCID: PMC4711844.
  • Zhang W, Yi B, Wang C, Chen D, Bae S, Wei S, Guo RJ, Lu C, Nguyen LL, Yang WH, Lillard JW, Zhang X, Wang L, Liu R. Silencing of CD24 enhances the PRIMA-1-induced restoration of mutant p53 in prostate cancer cells. Clin Cancer Res. 2015 Dec 28. PMID: 26712693.
  • Zhang L, Tran NT, Su H, Wang R, Lu Y, Tang H, Aoyagi S, Guo A, Khodadadi-Jamayran A, Zhou D, Qian K, Hricik T, Côté J, Han X, Zhou W, Laha S, Abdel-Wahab O, Levine RL, Raffel G, Liu Y, Chen D, Li H, Townes T, Wang H, Deng H, Zheng YG, Leslie C, Luo M, Zhao X. Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing. Elife. 2015 Nov 17;4. pii: e07938. PMID: 26575292.
  • Metge BJ, Mitra A, Chen D, Shevde LA, Samant RS. N-Myc and STAT Interactor regulates autophagy and chemosensitivity in breast cancer cells. Sci Rep. 2015 Jul 6;5:11995. PMID: 26146406; PMCID: PMC4648342.
  • Liu R, Liu C, Chen D, Yang WH, Liu X, Liu CG, Dugas CM, Tang F, Zheng P, Liu Y, Wang L. FOXP3 Controls an miR-146/NF-κB Negative Feedback Loop That Inhibits Apoptosis in Breast Cancer Cells. Cancer Res. 2015 Apr 15;75(8):1703-13. PMID: 25712342; PMCID: PMC4706751.
  • Che P, Yang Y, Han X, Hu M, Sellers JC, Londono-Joshi AI, Cai GQ, Buchsbaum DJ, Christein JD, Tang Q, Chen D, Li Q, Grizzle WE, Lu YY, Ding Q. S100A4 promotes pancreatic cancer progression through a dual signaling pathway mediated by Src and focal adhesion kinase. Sci Rep. 2015 Feb 13;5:8453. PMID:25677816 PMCID:PMC4326725
  • Chen D, Stueckle TA, Luanpitpong S, Rojanasakul Y, Lu Y and Wang L. Gene expression profile of human lung epithelial cells chronically exposed to single walled-carbon nanotubes. Nanoscale Research Letters. 2015 Jan 27;10:12. PMID:25852310 PMCID:PMC4314466
  • Chen D, Li Y, Wang L, Jiao K. SEMA6D Expression and Patient Survival in Breast Invasive Carcinoma. Int J Breast Cancer. 2015;2015:539721. PMID: 25973277; PMCID: PMC4417987.
  • Addison JB, Koontz C, Fugett JH, Creighton CJ, Chen D, Farrugia MK, Padon RR, Voronkova MA, McLaughlin SL, Livengood RH, Lin CC, Ruppert JM, Pugacheva EN, Ivanov AV. Cancer Res. 2015 Jan 15;75(2):344-55. PMID: 25421577 PMCID:PMC4297582
  • Anderson JC, Willey CD, Mehta A, Welaya K, Chen D, Duarte CW, Ghatalia P, Arafat W, Madan A, Sudarshan S, Naik G, Grizzle WE, Choueiri TK, Sonpavde G. High Throughput Kinomic Profiling of Human Clear Cell Renal Cell Carcinoma Identifies Kinase Activity Dependent Molecular Subtypes. PLoS One. 2015 Sep 25;10(9):e0139267. PMID: 26406598; PMCID: PMC4583516.
  • Lin CC, Sharma SB, Farrugia MK, McLaughlin SL, Ice RJ, Loskutov YV, Pugacheva EN, Brundage KM, Chen D, Ruppert JM. Kruppel-like factor 4 signals through microRNA-206 to promote tumor initiation and cell survival. Oncogenesis. 2015 Jun 8;4:e155. PMID: 26053033.
  • Li Y, Lu W, Chen D, Boohaker RJ, Zhai L, Padmalayam I, Wennerberg K, Xu B, Zhang W. KIFC1 is a novel potential therapeutic target for breast cancer. Cancer Biol Ther. 2015;16(9):1316-22. PMID: 26177331; PMCID: PMC4622065.


  • Individual Postdoctoral Fellowship in Applied Informatics from NLM/NIH. May 2001-April 2003
  • Charles Brooks Award for Creativity, UAB School of Health Professions. 2002
  • CUNY Fellowship for Ph.D. program in Biomedical Sciences. September 1993- September 1994