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Taneicia Mitchell NewsTanecia Mitchell, Ph.D., Assistant Professor with the University of Alabama at Birmingham Department of Urology, has been awarded an $2.7 million R01 grant to investigate the role of dietary oxalate on immune function in kidney stone disease. Read more

Shalev NewsIn groundbreaking diabetes research over the past two decades, Anath Shalev, M.D., Nancy R. and Eugene C. Gwaltney Family Endowed Chair in Juvenile Diabetes Research, has shown that the protein TXNIP regulates survival and function of beta cells, the pancreatic cells that produce the hormone insulin to lower levels of glucose in the blood. In an article in the journal Endocrinology, Shalev and colleagues now report that downregulation of alpha cell TXNIP can inhibit alpha cell glucagon secretion, which in turn may help explain the improvement in hyperglucagonemia and hyperglycemia observed in diabetic aTKO mice. Read more

Shi News 2In a report published in Nature Communications, researchers led by Lewis Zhichang Shi, M.D., Ph.D., and UAB Department of Radiation Oncology Chair James A. Bonner, M.D., created a cleaner mouse melanoma model by knocking out the receptor gene for interferon-gamma signaling. They used this improved knockout model, called IFNγR1KO, to probe the mechanisms of immune checkpoint blockers (ICB) resistance. Their findings support the possibility that melanoma might be treatable by bypassing therapeutic resistance to ICBs. Read more

James KobieIn collaborative studies, James J. Kobie, Ph.D., and Mark R. Walter, Ph.D., of the University of Alabama at Birmingham, and Luis Martinez-Sobrido, Ph.D., of the Texas Biomedical Research Institute, San Antonio, Texas, discovered a neutralizing monoclonalMark Walter antibody that potentially acts as a potent universal coronavirus therapy. Read more

Casey Weaver 2022For just the third time in history, a University of Alabama at Birmingham faculty member, Casey Weaver, MD from the Department of Pathology, has been elected to the prestigious National Academy of Sciences Read more

Allan Zajac 2022In a study published in the journal Science Immunology, Allan Zajac, Ph.D., and co-first authors Shannon M. Kahan, Ph.D., and Rakesh K. Bakshi, Ph.D., from the Department of Microbiology at UAB, show that two subsets of CD8 T cells develop to provide either short-term or long-term immune protection. The study focuses on one factor that guides this developmental bifurcation — interleukin-2 (IL-2). Read more

Casey Morrow 2022Koo 2022 Casey D. Morrow, PhD and Hyunmin Koo, Ph.D. have refined a microbiome “fingerprint” method that tracks sub-strain variants of a single gut microbe strain. The study was published in the journal Scientific Reports. Read more

Casey Weaver 2022In a study published in the journal Immunity, Carlene L. Zindl, Ph.D., and Casey T.Weaver, M.D, of the UAB Department of Pathology show how two types of immune cells — one a part of the innate immune system and the other a part of the adaptive immune system — play distinct and indispensable roles to defend that barrier. Read more

Beatriz Leon Ruiz 04052022Beatriz León, Ph.D., and her UAB colleagues unraveled a complex trail for the antagonistic mechanisms of LPS to promote or prevent allergic disease through activation or suppression of T helper-2 immune cells. Read more

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