A Phase III, Randomized, Multicenter, Double-Bling, Placebo-Controlled Clinical Trial of Omalizumab in Patients with Chronic Rhinosinusitis with Nasal Polyps

The purpose of this study is to determine the efficacy and safety of omalizumab compared with placebo in adult participants with chronic rhinosinusitis with nasal polyps (CRSwNP) who have had inadequate response to standard-of-care treatments.

Principal Investigators: Do-Yeon Cho, MD

Pain Management in Head and Neck Surgery Patients

The purpose of this study is to compare the use of a combined pain regimen with a traditional opioid pain regimen in the post-operative setting of moderate head and neck surgery operations. Our study aims to see if the addition of a scheduled non-opioid pain regimen will decrease the use and risk of opioid pain medications as well as improve pain control.

Principal Investigators: Erin P. Buczek, MD 

Voice and Swallowing Outcomes Following Revision Anterior Cervical Spine Surgery

The purpose of this research study is to document the voice and swallowing functions of patients undergoing revision anterior cervical spine surgery in an effort to find better ways to identify and treat complications that arise from this commonly performed procedure.

Principal Investigator: William Carroll, MD

Phase I, Open-Label Study Evaluating the Safety and Pharmacokinetics of Escalating Doses of Cetuximab-IRDye800 as an Optical Imaging Agent to Detect Cancer During Surgical Procedures

This is a Phase I trial designed to evaluate the safety of escalating dose levels of an investigational study drug, conjugated panitumumab-IRDye800, used in subjects with head and neck squamous cell carcinoma who undergo surgery with curative intent. It is hoped that this study will assist with finding better methods for identifying cancer intraoperatively for a more complete surgical resection.

Principal Investigator: William Carroll, MD

Single-Use Negative Pressure Wound Therapy for Free Flap Donor Sites

The purpose of this study is to investigate outcomes in the use of the PICO single-use negative pressure wound therapy device in selected surgical sites and compare it directly to the traditional post-operative dressing methods.

Principal Investigator: Brian Hughley, MD

Adherence and Outcome of Upper Airway Stimulation (UAS) for OSA International Registry

The purpose of this registry is to gather information on how the Inspire Upper Airway System (Inspire system) is used and performs for patients in the commercial setting. In addition, the information collected will continue to educate physicians who treat obstructive sleep apnea (OSA).

Principal Investigator: Kirk Withrow, MD

InspireĀ® Upper Airway Stimulation (UAS) System: Post Approval Study

The purpose of this study is to gather information in the post approval setting on how the Inspire Airway System (Inspire system) works and assess patient outcomes.

Principal Investigator: Kirk Withrow, MD

Prospective Observational Study to Evaluate Outcomes from Trans-oral Base of Tongue Resection for Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS)

The purpose of this study is to evaluate the use of robotic-assisted surgery for better visibility and access for trans-oral base of tongue resection, a common treatment for obstructive sleep apnea.

Principal Investigator: Kirk Withrow, MD

Invacaftor for Acquired CFTR Dysfunction in Chronic Rhinosinusitis (EDSPD Protocol)

The purpose of this study is to establish the novel endoscopically-directed sinus potential difference (EDSPD) assay as an endpoint for therapy of sinus disease. This assay provides a means to measure CI-secretion across the sinus epithelium in human subjects with chronic rhinosinusitis (CRS) and test the relationship between this data and endoscopic findings of inflammation. 

Principal Investigator: Bradford Woodworth, MD

Chloride Secretagogues for Acquired CFTR Dysfunction in Chronic Rhinosinusitis (NPD Protocol)

The purpose of this study is to determine if acquired (partial) Cystic Fibrosis Transmembrane conductance Regulator (CFTR) deficiency contributes substantially to the pathogenic mechanisms underlying Chronic Rhinosinusitis (CRS), creating a localized environment that impairs mucociliary clearance (MCC).

Principal Investigator: Bradford Woodworth, MD