RamanProfessor of Medicine


Address: 
 

Shelby Building, Room 305
1825 University Boulevard
35294-2182

Telephone:(205) 934-2472
Email: craman@uab.edu

 

Education

BSc (Zoology), Madras University, India
MSc (Microbiology), Idaho State University
PhD (Microbiology-Immunology), Southern Illinois University
Postdoctoral Studies, Loyola University in Chicago, Stritch School of Medicine, with Dr. Katherine Knight

 

Research Description


Dr. Raman’s laboratory interrogates molecular and cellular mechanisms driving the immunopathogenesis of autoimmune diseases with a special emphasis on multiple sclerosis (MS) and rheumatoid arthritis (RA). Within this are of research, the current studies focus on molecular mechanisms underlying activation and differentiation of effector T cells, B cells and innate cells in the pathogenesis of these autoimmune diseases. Current investigations involve human immunology bridged with mouse models to study RA and MS. The major area of investigation is immunopathogenesis of multiple sclerosis. We have several interrelated projects in this area of investigation:

i. Type 1 IFNs (IFN-α and IFN-β) and type 2 IFN (IFN-γ) in pathogenesis and regulation of MS and RA – Our studies primarily focuses on outcomes of signaling from the IFN receptors in different innate and adaptive immune cell populations. Our immunopathogenic mechanism driving progression of multiple sclerosis (MS) that involves human studies and the mouse model, experimental autoimmune encephalomyelitis (EAE).

ii. Molecular mechanisms by which CK2 and GSK3 modulates effector and regulatory cells in the pathogenesis of autoimmunity.

iii. Role of CD5 in T cell and B-1a B cell development, differentiation, immunity and pathogenesis – the laboratory focuses on B-1a B cell-dependent T-independent antibody responses, T-dependent antibody responses, autoreactive B-cell generation and persistence and regulatory B-cells. For these studies, the Raman laboratory has generated unique knock-in CD5 mutant mice in which signaling domains associated with CD5-inhibitory activity (ITIM) and CD5-CK2 activation have been ablated.

iv. TGFβR3/betaglycan dependent regulation of adaptive immune effector cells in the pathogenesis of autoimmune diseases

 

Publications

Click here for a more complete list of publications. Below are a few selected papers


Ortega-Francisco S, de la Fuente-Granada M, Alvarez-Salazar EK, Bolaños-Castro LA, Fonseca Camarillo G, Olguin Alor R, Alemán-Muench GR, López-Casillas F, Raman C, García-Zepeda EA, Soldevila G. 2017. TβRIII is induced by TCR signaling and downregulated in FoxP3+ regulatory T cellsM. Biochem Biophys Res Commun. 2017 Oct 16; PMID: 29050936.


Mier-Aguilar CA, Cashman KS, Raman C, Soldevila G. 2016. CD5-CK2 Signaling Modulates Erk Activation and Thymocyte Survival. PLoS One. 11(12):e0168155.  PMID: 28030587;  PMCID: PMC5193405.


Tang Q, Danila MI, Cui X, Parks L, Baker BJ, Reynolds RJ, Raman C, Wanseck KC, Redden DT, Johnson MR, Bridges SL Jr. 2015. Expression of Interferon-γ Receptor Genes in Peripheral Blood Mononuclear Cells Is Associated With Rheumatoid Arthritis and Its Radiographic Severity in African Americans. Arthritis Rheumatol. 67(5):1165-70.  PMID: 25708927; PMCID: PMC4414815.


Naves R, Singh SP, Cashman KS, Rowse AL, Axtell RC, Steinman L, Mountz JD, Steele C, De Sarno P, Raman C. 2013.  The interdependent, overlapping, and differential roles of type I and II IFNs in the pathogenesis of experimental autoimmune encephalomyelitis. J Immunol. 191(6):2967-77. PMID: 23960239; PMCID: PMC3779698.


Axtell RC, de Jong BA, Boniface K, van der Voort LF, Bhat R, De Sarno P, Naves R, Han M, Zhong F, Castellanos JG, Mair R, Christakos A, Kolkowitz I, Katz L, Killestein J, Polman CH, de Waal Malefyt R, Steinman L, Raman C. 2010. T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis. Nat Med. 16(4):406-12. PMID: 20348925; l PMCID: PMC3042885.

 

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