The Department of Urology at UAB is actively involved in both clinical, basic science, and translational research endeavors. We have a large tissue and biologic fluids library of hundreds of urologic cancer specimens for internal study. This repository is a basis through which we are attempting to identify markers and characteristics to stratify patients into risk groups. We are also investigating renal ischemia in an animal model to identify means of optimizing renal function and markers that predict outcomes.  Our residents spend 4 month blocks performing both clinical and basic science research during their tenure at UAB.

The Department of Urology participates in multiple clinical trials. We are members of the Eastern Cooperative Oncology Group and Early Detection Research Network (branch of the National Cancer Institute), actively involved in multi-institutional studies in urologic cancer. Our translational involvement in chemoprevention studies of bladder and prostate cancer is part of the chemoprevention consortium of our NCI Comprehensive Cancer Center. We participate in numerous non-cancer studies including investigating the feasibility of tissue engineering and the role of bladder replacement in both pediatric and neuro-urology patient populations.

We are currently enrolling patients for multiple studies:

- Predictors of microsurgical varicocele ligation, and mechanisms of male infertility

- We are part of a nationwide Andrology Research Consortium evaluating etiologies, treatments, and outcomes for male infertility

- A study combining Bacillus Calmette-Guerin (BCG) with ALT-803, an immunomodulator, in patients undergoing treatment for non-muscle invasive bladder cancer
https://clinicaltrials.gov/ct2/show/NCT02138734?term=ALT-803&rank=6

- Pomegranate juice extract (Pomex) and its role in prostate cancer patients on active surveillance
https://clinicaltrials.gov/ct2/show/NCT02095145?term=pomx&rank=10

- The Rare Diseases Clinical Network provides funding for our study on cystinuria patient with kidney stone disease
https://clinicaltrials.gov/ct2/show/NCT00588562?term=cystinuria&rank=3

- We also have a state-of-the-art kidney stone laboratory with multiple NIH-funded scientists studying kidney stone disease
https://www.uab.edu/medicine/urology/research/kidney-stone-laboratory


For more information on these studies, including how to enroll, please contact Ralee' Bunt at 205-934-2272, or Lisa Harvey at 205-996-2613