XENOTRANSPLANT
Update: UAB Heersink School of Medicine researchers show genetically modified pig kidneys provide life-sustaining kidney function.
Genetically modified pig kidneys provide “life sustaining kidney function” in latest Parsons model study — all while using current standard-of-care immunosuppression medication. It is the first time xenotransplanted pig kidneys have showed function and renal clearance, say UAB researchers.
Xenotransplant is defined as transplanting an animal organ or product into a human to cure disease. Utilizing genetically modified pig kidneys could provide an increased supply for those needing a kidney transplant.
Why do we need xenotransplantation?
“We have this amazing therapy called kidney transplantation that works 95 to 98 percent of the time, and yet there are only about 25,000 kidneys to go around in the U.S. every year, but we have 800,000 people who need them. The hardest part is seeing patients in clinic and wait-listing them knowing they might actually die before I ever get an organ-offer to transplant them.
So the opportunity to have an organ that is waiting there for the person who needs it is just overwhelming to think about. I feel very privileged to be just a tiny part of a really big puzzle that people have been working on for many years.”
- Dr. Jayme Locke, Director, Division of Transplantation,
Heersink School of Medicine
UAB advances the science in 2023
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New study: Pig kidneys — for the first time — demonstrate “life-sustaining kidney function” in a human
This study, performed in a pre-clinical human model, is the first time xenotransplanted pig kidneys have shown clearance of creatinine and shown a standard immunosuppression regimen may be sufficient.Read how we’re advancing the science7548 viewsRead more about UAB’s 2022 breakthrough
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Pig kidneys to humans: next steps for the UAB xenotransplantation program
UAB physicians are working on the next steps to begin compassionate or emergency use of the pig kidneys in living humans. Two major approvals will be required.What’s on the horizon for xenotransplantation?14279 views
UAB announces first clinical-grade transplant of gene-edited pig kidneys into brain-dead human
In the study published in the American Journal of Transplantation, UAB researchers tested the first human preclinical model for transplanting genetically modified pig kidneys into humans.Why did UAB publish this study?39188 views
Selfless act paves the way for more people to receive lifesaving organs
Jim Parsons’ legacy paves the way for thousands to potentially receive lifesaving organs through UAB’s xenotransplantation program.The Parsons family and their gift15127 views
The 10-gene pig and other medical science advances enabled UAB’s transplant of a pig kidney into a brain-dead human recipient
The human preclinical model at UAB provides important knowledge before a Phase I clinical trial can begin for living human recipients. Decades of work by researchers across the world preceded UAB’s first clinical-grade pig kidney xenotransplant.The science behind the study18535 views
Pig-to-human kidney transplant one of many feats for Locke, UAB Comprehensive Transplant Institute
From its incompatible kidney transplant program to deceased donor programs, to xenotransplantation, UAB continues to seek ways to help patients who face end-stage renal disease.Meet Jayme Locke, M.D.9828 viewsStories about the 2022 project
Photos from 2022
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Dr. Jayme Locke and the UAB xeno transplant team.
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The team preparing the porcine kidneys for transplantation into the brain-dead recipient.
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Dr. Jayme Locke with UAB's kidney transplant and xeno transplant teams.
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Jim Parsons enjoying his passion for motorcycles in 2003.
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Jim with his three children, Cole, David and Ally, celebrating Ally’s graduation from high school.
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Jim at the top of American flag mountain in Colorado.
Pointing the way forward: This study was conducted to meet the same standards as a Phase I clinical trial, making it mirror — as much as possible — every step of a normal transplant between humans.
First peer-reviewed, published study on a clinical-grade genetically modified pig kidney xenotransplant in a human, in which native kidneys were removed from the human recipient and pig kidneys were transplanted inside the body.
Prior to surgery, the team validated a UAB-developed compatibility test to determine that the genetically modified pig kidney was a good tissue match for the human recipient.
The pig kidneys were placed in the same anatomic locations used for human donor kidneys, with the same attachments to the renal artery, renal vein and to the ureter that carries urine from the kidney to the bladder.
UAB’s breakthroughs in the news
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Pig organs for transplant patients
Nouvelle greffe d’un rein de porc chez un humain aux États-Unis
Kidneys From a Genetically Altered Pig Are Implanted in a Brain-Dead Patient
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