Preclinical Imaging Shared Facility

Research Administration Centers and Cores Preclinical Imaging Shared Facility

Preclinical Imaging Shared Facility

Directory Category: Institutional Core

The Preclinical Imaging Core was established to enable UAB researchers to apply non-invasive, molecular imaging technologies in animal models. Imaging is accomplished with a range of imaging modalities, including gamma camera imaging, X-ray CT, microPET/CT, microSPECT/CT, bioluminescence, fluorescence, magnetic resonance (MR) imaging, and ultrasound imaging. It is expected that the successful application of small animal imaging will speed efforts to translate basic research to human clinical trials. The facility has undertaken a multimodality imaging approach to provide a molecular understanding of cancer in animal models by integrating measurements of tumor mass (bioluminescence, ultrasound, CT, and MR), tumor specific targeting (SPECT, ultrasound, fluorescence, microPET), vascular parameters (ultrasound, MR), and specific therapy responses (ultrasound, bioluminescence, SPECT, MR, micoPET). Each imaging modality has advantages and their coordinated application is synergistic.  The facility meets a critical need in evaluation of new therapies for cancer in animal models, thereby enabling translation of the new therapies to human trials.