Gnotobiotic and Genetically-Engineered Mouse Core

Research Administration Centers and Cores Gnotobiotic and Genetically-Engineered Mouse Core

Gnotobiotic and Genetically-Engineered Mouse Core

Directory Category: Institutional Core

In the last two decades it has become clear that the microbiota (microbial inhabitants) of the human body and their interactions with the host are far more complex than previously recognized, and have major roles in health and disease, including inflammatory bowel diseases (IBD; Crohn’s disease and ulcerative colitis, obesity, type 2 diabetes, hypertension, atherosclerosis, colon cancer, hypersensitivity diseases such as asthma, hepatic metabolism of xenobiotics, and neurological development and behavior. Gnotobiotic and “humanized” animal models are essential tools for investigating the role of the microbiome in health and disease. The purpose of this facility is to provide UAB investigators access to such models.