At any given time, the Department of Anesthesia and Perioperative Medicine has more than 50 ongoing clinical research studies. The Department also hosts several large, multi-center, industry-sponsored trials.

Examples of recent clinical research projects include:

Ryan Almeida, M.D.

High-Frequency Nerve Block for Post-Amputation Pain: A Pivotal Study (Neuros)

Andrew Barker, M.D.

Impact of temperament on the Development of Post-Operative Emergence of Delirium in Children Ages 2 to 8 years

Gwen Boyd, M.D.

Cataract Surgery in a Series of LVAD Patients

Ophthalmic Surgery Morbidity and Mortality: A Retrospective Study 1990-2010

Venous Air Embolism During Ophthalmic Surgery

Ayesha Bryant, M.S.P.H., M.D.

Intraoperative Tourniquet Use and Patients Undergoing Regional Anesthesia

Modifiable Factors that Impact Long-Term Quality of Life and Development of Chronic Pain after Pulmonary Resection

Evaluation of a Method to Increase Adoption of the Optimal Technique for Decreasing Post-Dural Puncture Headaches among Non-Anesthesiologists Performing Diagnostic Lumbar Punctures

Tekuila Carter, M.D.

Novel Biomarkers of Pre-eclampsia:  Aquaporins, Fatty Acids, and S100B

Jack Crawford, M.D., Ph.D.

Impact of Preoperative Steroids on Adrenal Insufficiency and Clinical Outcomes after Neonatal Cardiac Surgery with Cardiopulmonary Bypass

Jeffrey Dobyns, D.O.

Noble Gas Effects on Human Natural Killer Cell Activity and Toxicity

Joel Feinstein, M.D.

Dose Escalation of Dexamethasone to Increase Duration of Transversus Abdominal Plane Block Following Cesarean Section: A Prospective Randomized Double-Blinded Clinical Study

Michael Froelich, M.D., M.S.

Sedation and Pain: The Effect of Sedation on Pain Perception

Effect of Sedation on Cognitive Performance in the Elderly

Christopher Godlewski, M.D.

Superficial Cervical Plexus Blockade for Clavicle Fracture Analgesia

Optimal Injection Site for Serratus Anterior Plane Block in Reconstructive Breast Surgery

Promil Kukreja, M.D., Ph.D.

Effectiveness of Perineural Clonidine as an Adjuvant with Ropivacaine for Popliteal Nerve Block in Patients Undergoing Foot and Ankle Surgery

Factors influencing PACU discharge times following spinal anesthesia for cerclage placement and dilation and curettage- a retrospective study

Mali Mathru, M.D.

Remote Ischemic Preconditioning Living Donor Renal Transplant Protocol

Red Blood Cell Transfusion May Exacerbate Cerebral Vasospasm Associated with Subarachnoid Hemorrhage  

Peter Nagi, M.D.

Intraoperative Low-dose Ketamine Infusion for Patients with Obstructive Sleep Apnea: A Prospective, Randomized, Controlled, Double-Blind Study Protocol  

Timothy Ness, Ph.D., M.D.

Comparison of hemodynamic changes under general anesthesia in patients receiving preoperative block therapy

Intraoperative Hemodynamic Effects and Postoperative Pain Control with a Continuous Epidural Infusion under General Anesthesia

Jean-Francois Pittet, M.D.

Coagulopathy in Severe Pediatric Trauma with and without Head Injury

Effect of Autonomic Nervous System Activity and Early Coagulation Abnormalities on the Development of Systemic Immunosuppression and Nosocomial Pneumonia in Patients with Vascular or Traumatic Brain Injury

Importance of the Type III Secretion (T3SS) Toxin ExoY in the Severity of P. Aeruginosa Pneumonia in ICU Patients

Coagulopathy and Nosocomial Pneumonia After Severe Trauma

A Clinical Proof-of-Concept Study for the Perioperative Surgical Home

The Role of Exo-induced tau phosphorylation in the development of cognitive dysfunction in ICU patients after nosocomial pneumonia

William Potter, M.D.

Association of Intra-operative Hypotension and Post-operative Outcomes in Elective Non-cardiac Surgery

A Comparison of the Efficacy of Continuous Nerve Block with Stimulating Catheters placed under Ultrasound Guidance versus Non-stimulating Catheters placed under Ultrasound

Mark Powell, M.D.

Utility of Ultrasound in Identification of Midline and Placement of Epidural in Severely Obese Parturients: A Randomized, Prospective Study

Comparing Bupivacaine, Lidocaine, and a Combination of Bupivacaine and Lidocaine for Labor Epidural Activation: A Prospective, Randomized, Double-Blind Study

Comparing Low-dose Bupivacaine with Epidural Volume Extension to Standard Bupivacaine dosing for short obstetric procedures: A prospective, randomized study

Assessment of the Endothelial Glycocalyx of an Ex Vivo Preparation of Human Umbilical Veins after Exposure to a Simulated Colloid and Crystalloid Bolus

A Randomized Controlled Trial of Regional Versus General Anesthesia for Promoting Independence after Hip Fracture (REGAIN trial)

Blair Smith, M.D.

Nitrite Infusion in Islet Cell Transplantation:  Test of Clinical Efficacy and Determination of Cytoprotective Mechanisms

Yasser Sakawi, M.D.

Quality Improvement of post-partum neuromuscular complications using retrospective and prospective chart review of a recently instituted clinical protocol

Roland Short, M.D.

Hospital Naloxone Administration Rates Before and After Implementation of Standardized Patient Controlled Analgesia (PCA) Order Sets and Capnography Monitoring

Oral Morphine Equivalents as a Predictor for Morbidity and/or 30 day Readmission Following Surgery 

Vinod Singh, M.D.

Incidence of Acute Kidney Injury in Neurologically Injured Patients Receiving Hypertonic Sodium Chloride versus Hypertonic Sodium Acetate Intravenous Solutions

Efficacy of Ketamine Infusion Compared with Traditional Anti-epileptic agents in refractory status epilepticus: a pilot study

Use of Cumulative Summation (CUSUM) Scoring for Defining Competence in Central Venous Line Insertion in Inexperienced Trainees

Kenneth Smithson, D.O.

Volatile anesthetics may upregulate Glioblastoma Multiforme Tumor Promotor

Ahmed Zaky, M.D., M.P.H.

Right Ventricular Dysfunction in Pregnancy-Induced Hypertension: a Pilot Study

The Role of Intravenous Fluid and Vasoactive Agents Resuscitation in the Development of Early Acute Kidney Dysfunction in Two Cohorts of Intensive Care Unit Patients