The Research Integration Venture (REINVENT) program is a collaborative research seed funding program for faculty projects within the Department of Anesthesiology and Perioperative Medicine.
The goal of REINVENT is to promote innovative research, encourage the integration of our clinical, basic, and translational research faculty, foster mentorship, and allocate resources (both time and money) transparently and competitively, with an eye toward future project sustainability. As a merit seed funding program, it encourages both intra-departmental and inter-departmental collaborations and team building, availability of academic time and financial support.
Collaboration is encouraged between clinical and basic/translational faculty; projects can focus on any aspect of research including clinical, education, quality, and operations.
If you have questions about abstracts, contact Brant Wagener at bwagener@uabmc.edu. If you have questions about redcap or your submission, contact Brittany Massie at bmassie@uabmc.edu.
Click here to access the online submission form in REDCap.
Awardees
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Spring 2023
Aftab Ahmad, Ph.D., (PI), David W. Miller, M.D., (Co-PI), John C. Briggs, M.D., (Co-I)
Circulating Factors and Multiorgan Dysfunction in ARDS
Andre F. Gosling, M.D., (PI), Ryan C. Godwin, M.S., Ph.D., (Co-PI), Ryan L. Melvin, M.A., Ph.D., (Co-PI)
Measurement of Pulse Arrival and Transit Times to Approximate Arterial Stiffness in Cardiac Surgery Patients
Weifeng Song, M.D., Ph.D., (PI), Ryan L. Melvin, M.A., Ph.D., (Co-PI), Ryan C. Godwin, M.S., Ph.D., (Co-I)
Continous Assessment of Cerebral Autoregulation After Subarachnoid Hemmorrhade in Neuro ICU: A Feasibility Study -
Summer 2022
Tekuila Carter, MD (PI), Lee Ann Riesenberg, PhD, MS, RN (Co-I)
Tools for Direct Observation and Assessment of Anesthesiology Resident Procedure Skills: A Systematic ReviewJennifer DeBerry, PhD (PI), Promil Kukreja, MD, PhD (Co-I), Rakesh Patel, PhD (Co-I), Ryan Melvin, PhD (Co-I), Ryan Godwin, PhD (Co-I)
Effects of sustained-release oral sodium nitrite supplementation on pain-related outcomes and peri- and postoperative physiology in people undergoing unilateral all-component revision total knee arthroplastyMichelle D Tubinis, MD (PI), Hanna Hussey, MD (Co-PI), Tamas Jilling, MD (Co-PI), Saravanakumar Murugesan, PhD (Co-I)
Angiotensinogen/Vasorin Ratio in Peripheral Blood (PLASMA) as Biomarker of Preeclampsia -
Spring 2021
Epithelial ion channels expression and function regulation in pulmonary aspiration
Riaz Karukappdath, M.D.
Mitochondrial dysfunction contributes to sepsis induced cardiac dysfunction -
Rapid REINVENT
Due to the COVID-19 pandemic, our regular Spring REINVENT cycle was deferred and the Rapid REINVENT program was implemented in April. The purpose of the program was to promote and encourage innovation in COVID-19 research. Seven projects received funding in the first cycle in April and five projects received funding in May.
April Cycle
Kevin S. Harrod, Ph.D. (PI), Brant Wagener, M.D., Ph.D. (Co-I), Jessy Deshane, Ph.D. (Co-I)
Modeling of COVID-19 and SARS-CoV-2 in human lung epithelium.
Qiang Ding, Ph.D., Kevin S. Harrod, Ph.D., Brant Wagener, M.D., Ph.D., Jean-Francois Pittet, M.D.
Repurposing already-available drugs to treat COVID-19; a pilot study for the effect of already-available drugs on COVID-19 virus entry and replication in lung epithelial and endothelial cells
Jean-Francois Pittet, M.D., DEAA and Jaroslaw W. Zmijewski, Ph.D.
Therapeutic recovery of immunosuppression and metabolic maladaptation induced by COVID-19 infection
Dylan R. Addis, M.D.
Investigation of VEGF and sFlt-1 levels in the pathogenesis and severity of COVID-19 disease
Zhen Zheng, M.D. M.S.
Penehyclidine protects lung from SARS-CoV-2-induced endothelial barrier disruption via limiting MLC2 phosphorylation - A novel intervention to ARDS in COVID-19
Brant Wagener, M.D. Ph.D., Timothy J. Ness, M.D. Ph.D., Sonya Heath, M.D., Sadis Matalon, Ph.D., D.Sc.
Exploratory study of the effect of tranexamic acid treatment on the progression of COVID-19 in Outpatients
Sadis Matalon, PhD, D.Sc. (PI), Ahmed Lazrak, D. Sc., (Co-PI)
Inhibition of Lung Ion Channel Activities by SARS CoV-2 S (spike) ProteinMay Cycle
PI: Shama Ahmad, Ph.D., Co-PI: Aftab Ahmad, Ph.D.
Protease activated receptor (PAR) dependent cardiomyocyte damage due to SARS-CoV2 Spike protein
Co-PIs: Jean-Francois Pittet, M.D., Marisa Marques, M.D., Jori May, M.D. and Nita Limdi, Ph.D.
Insights into COVID-19-Mediated Activation of the Coagulation Cascade
PI: Saurabh Aggarwal, M.D., Ph.D.
The role of SARS-CoV-2 Spike Protein in Impairing Bactericidal Function of Macrophages: Therapeutic Potential of Raltegravir
PI: Jianguo Gu, M.B., Ph.D.; Co-PI: Sadis Matalon, Ph.D., Dr.Sc. (Hon.), FAPS
Neurogenic lung inflammation and its therapeutic implications in COVID-19
PI: Promil Kukreja, M.D.,Ph.D., Co-I: Hari Kalagara, M.D., Peter Nagi, M.D., Jeff Dobyns, M.D., MSHA
Effects of COVID pandemic on care and outcomes of elderly hip fracture patients. -
Fall Cycle 2020
Andrew Barker, M.D.
The Effect of Guanfacine on Delirium in Elderly Critically Ill PatientsMark Powell, M.D.
Exosome cargo from preeclamptic patients mediates endothelial dysfuntion, subsequent cardiovascular remodeling, and the preeclamptic pehnotypeAlethia Selliers, M.D.
Precision Medicine in Anesthesia: Genetic Component in Opioid-induced Respiratory Depression
Contact
Brant Wagener, M.D., Ph.D.
Resident researchers are available through the RMRET program. Please contact Dr. Wagener for questions.
Ayesha Bryant, M.D., MSPH
IRB and regulatory assistance is available via Dr. Bryant. Applicants are encouraged to meet with Dr. Bryant prior to submitting their proposal to discuss the timeline required to obtain the necessary regulatory approval.