Charles O. Elson, III, MD - Selected Recent Publications in Peer Reviewed Journals

Feng T, Qin H, Wang L, Benveniste EN, Elson CO, Cong Y. 2011. Th17 Cells Induce Colitis and Promote Th1 Cell Responses through IL-17 Induction of Innate IL-12 and IL-23 Production. J Immunol. 186(11):6313-8. PMID:21531892


Feng T, Elson CO, Cong Y. 2010. Microbiota: Dual-faceted player in experimental colitis. Gut Microbes. 1(6):388-391. PMID:21468221


Saleh M, Elson CO. 2011. Experimental inflammatory bowel disease: insights into the host-microbiota dialog. Immunity. 34(3):293-302. PMID:21435584


Feng T, Cao AT, Weaver CT, Elson CO, Cong Y. 2011. Interleukin-12 Converts Foxp3(+) Regulatory T Cells to Interferon-γ-Producing Foxp3(+) T Cells That Inhibit Colitis. Gastroenterology. 140(7):2031-43. PMID:21419767


Feng T, Elson CO, Cong Y. 2011. Treg cell-IgA axis in maintenance of host immune homeostasis with microbiota. Int Immunopharmacol. 11(5):589-92. PMID:21111079


Feng T, Elson CO. 2011. Adaptive immunity in the host-microbiota dialog. Mucosal Immunol. 4(1):15-21. PMID:20944557


Feng T, Cong Y, Qin H, Benveniste EN, Elson CO. 2010. Generation of mucosal dendritic cells from bone marrow reveals a critical role of retinoic acid. J Immunol. 185(10):5915-25. PMID:20944006


Feng T, Wang L, Schoeb TR, Elson CO, Cong Y. 2010. Microbiota innate stimulation is a prerequisite for T cell spontaneous proliferation and induction of experimental colitis. J Exp Med. 2010 Jun 7;207(6):1321-32. Erratum in: J Exp Med. 207(7):1569. PMID: 20498021


Cong Y, Feng T, Fujihashi K, Schoeb TR, Elson CO. 2009. A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota. Proc Natl Acad Sci U S A. 106(46):19256-61. PMID: 19889972


Cong Y, Wang L, Konrad A, Schoeb T, Elson CO. 2009. Curcumin induces the tolerogenic dendritic cell that promotes differentiation of intestine-protective regulatory T cells. Eur J Immunol. 39(11):3134-46. PMID: 19839007


Shih DQ, Kwan LY, Chavez V, Cohavy O, Gonsky R, Chang EY, Chang C, Elson CO, Targan SR. 2009. Microbial induction of inflammatory bowel disease associated gene TL1A (TNFSF15) in antigen presenting cells. Eur J Immunol. 39(11):3239-50. PMID: 19839006


Qin H, Wang L, Feng T, Elson CO, Niyongere SA, Lee SJ, Reynolds SL, Weaver CT, Roarty K, Serra R, Benveniste EN, Cong Y. 2009. TGF-{beta} Promotes Th17 Cell Development through Inhibition of SOCS3. J Immunol. 183(1):97-105. . PMID: 19535626.


Lee YK, Turner H, Maynard CL, Oliver JR, Chen D, Elson CO, Weaver CT. 2009. Late developmental plasticity in the T helper 17 lineage. Immunity. 30(1):92-107. PMID: 19119024.


Mestecky J, Elson CO. 2008. Peyer's patches as the inductive site for IgA responses. J Immunol. 180(3):1293-4. PMID: 18209022.


Qin H, Roberts KL, Niyongere SA, Cong Y, Elson CO, Benveniste EN. 2007. Molecular mechanism of lipopolysaccharide-induced SOCS-3 gene expression in macrophages and microglia. J Immunol. 179(9):5966-76. PMID: 17947670.


Mestecky J, Russell MW, Elson CO. 2007. Perspectives on mucosal vaccines: is mucosal tolerance a barrier? J Immunol. 179(9):5633-8.  PMID: 17947632.


Duck LW, Walter MR, Novak J, Kelly D, Tomasi M, Cong Y, Elson CO. 2007. Isolation of flagellated bacteria implicated in Crohn's disease. Inflamm Bowel Dis. 13(10):1191-201. PMID: 17712838.


Elson CO
, Cong Y, Weaver CT, Schoeb TR, McClanahan TK, Fick RB, Kastelein RA. 2007. Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice. Gastroenterology. 132(7):2359-70.  PMID: 17570211.


Konrad A, Cong Y, Duck W, Borlaza R, Elson CO. 2006. Tight mucosal compartmentation of the murine immune response to antigens of the enteric microbiota. Gastroenterology. 130(7):2050-9. PMID: 16762628.


Mangan PR, Harrington LE, O'Quinn DB, Helms WS, Bullard DC, Elson CO, Hatton RD, Wahl SM, Schoeb TR, Weaver CT. 2006. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature. 441(7090):231-4. PMID: 16648837.


Elson CO
, Cong Y, McCracken VJ, Dimmitt RA, Lorenz RG, Weaver CT. 2005. Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota. Immunol Rev. 206:260-76.  PMID: 16048554.


Lorenz RG, McCracken VJ, Elson CO. 2005. Animal models of intestinal inflammation: ineffective communication between coalition members. Springer Semin Immunopathol. 27(2):233-47.  PMID: 16028027.