UAB - School of Medicine - O'Brien Center

O'Brien Core Center for Acute Kidney Injury Research Core Usage Request Form.

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NIHOther FederalFoundationInstitutional FundsOther

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See Core Request Form PDF for more detailed descriptions of each core and assay/technique.

Check desired core resources for your project and any other pertinent information.

Biostatistical Core

Analysis of pilot data
Design of epidemiological, clinical studies or clinical trials
Sample size and/or power analysis
Analyses of study results
Database development
Forms and/or instrument development

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Clinical Studies in AKI (Core A)

Study Planning and Design
Study Initiation and Conduct
Study Analysis and Interpretation (in Conjunction with Biostatistical Core)
Biological Sample Repository
Design of Genetic studies of AKI
Design of single nucleotide polymorphism assays
Preparation of genomic DNA, with quality control
Performance of single nucleotide polymorphism assays
QC of SNP assays
Informatics and statistical genetics of SNP information

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Pre-Clinical Studies of AKI (Core B)

Orthotopic Kidney Transplantation
Heterotopic Heart Transplantation
Orthotopic Abdominal aorta transplantation
Renal ischemia/reperfusion
Nephrotoxin-induced models of AKI
Rhabdomyolysis model of AKI
Other Procedures
Arterio-venous fistula
Use of Microsurgical Workstation
Hands-on training of a surgical protocol
Isolation and culture of primary cell lines
Functional renal imaging analysis
Ultrasound
MicroCT
Gamma Camera
SPECT/CT
Bioluminescence
Fluorescence
Whole kidney clearance and oxygen consumption studies
Tissue oxygen partial pressure determination in kidney
Nitric oxide generation
Invitro assessment of O2 consumption by isolated proximal tubule segments
Micropuncture for nephron function and tubuloglomerular feedback
Metabolic cage experiments in mice
Radioimmunoassay of angiotensin II
Videometric flow velocitometry (VMFV)

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Bioanalytical Core (Core C)

Training in proteomics and mass spectrometry approaches
Consultation for analysis of oxidative stress biomarkers in AKI
Biomarkers for AKI
Serum/plasma/urine creatinine determination by isotope dilution LC-MS/MS
Assays for oxidative stress markers
Oxidized fatty acid LC-MS/MS
Bioenergetics and Mitochondrial Function Assessment for AKI
Assays for post-translational modification of proteins
Quantitative analysis of Krebs cycle and glycolytic intermediates by LC-MS/MS

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If you would prefer to submit a copy of the filled out PDF please do so here:

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Please remember to cite the grant DK079337 and acknowledge UAB-UCSD O’Brien Center for support.

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