Overview


 Educational and Enrichment programs of the UAB-UCSD O'Brien Center are intended to:

  • Catalyze collaborative interactions among Center members
  • Enhance the conceptual, technical and methodological expertise of UAB-UCSD investigators
  • Foster the development of new, innovative projects that emphasize potential translation to clinical studies
  • Facilitate the training of the next generation of investigators interested in kidney-related research

Dr. Agarwal co-ordinates the overall educational program and Dr. Mehta oversees these program implementations at UCSD.
The following are a list of various events conducted by the center
  • The Annual AKI Symposium
  • The Rodent Kidney Physiology/Injury Workshop
  • The Core Competencies in Kidney Research Seminar Series
  • Annual National Metabolomics Workshop
  • The Annual Comprehensive Research Symposium
  • The O'Brien Center Lecture Series
  • Nano-Sabbatical and Micro-Sabbatical programs
  • Summer Students Training Program for Medical Students

Sabbatical Program


Nano-sabbatical and Micro-sabbatical Program

This program allows interested investigators to visit the Center and acquire new experimental techniques that they can utilize to address their experimental questions or to pursue new methods, technology and develop novel lines of investigations.

Nano-sabbatical: This program lasts 1 to 2 days

Micro-sabbatical: This program lasts 1 to 2 weeks.

Your time in a sabbatical is intended to provide training tailored to your needs and can include any of the following plus more.

  1. Models of AKI
  2. Kidney Transplantation techniques and training
  3. Collecting and growing primary cell lines
  4. Determining oxygen consumption
  5. Assays for Ang II and other molecules

After returning to your institution, interactions with appropriate faculty will be maintained to help with trouble shooting and establishment of the methods at your institution.

Symposia & Workshops



The Annual AKI Symposium


This one-day symposium, is held in conjunction with the annual International CRRT meeting in San Diego.  These content-focused workshops and symposia involve not only experts from UAB and UCSD but also outstanding investigators in the AKI field. 

AKI Symposium 2017
AKI Symposium 2016

AKI Symposium 2015

AKI Symposium 2014

AKI Symposium 2013

AKI Symposium 2012
AKI Symposium 2011

Annual Comprehensive Research Symposium

The UAB-UCSD O'Brien Core Center sponsors and annual comprehensive symposium.  This is a one-day event and alternates between UAB and UCSD.  Invited scientists include a keynote speaker (prominent investigator in the AKI field), selected speakers from the Center membership, and short presentations from each of the Pilot Study awardees.  The entire symposium is broadcast live at both UAB and UCSD campuses via video conferencing.

This symposium is open to all UAB/UCSD students and faculty as well as all members of the Extended Research Base. It has served as a centerpiece of the Educational Enrichment Program, providing unparalleled opportunities for multidisciplinary interactions.  In addition, this symposium provides an excellent opportunity to recruit new students to AKI-related research. The expense of this important educational activity has been covered, in part, by the Administrative Core and when possible, outside sources (e.g. foundation awards, educational grants from industry).

Annual Comprehensive Research Symposium 2012
Annual Comprehensive Research Symposium 2011
Annual Comprehensive Research Symposium 2010
Annual Comprehensive Research Symposium 2009

Core Concepts in Kidney Research Seminar Series

This annual basic science seminar series is held at UAB (was previously know as the Core Competencies Seminar Series).  This seminar series is led by Dr. Lisa Curtis and is designed to provide a basic approach to the study of renal disease using animal models

Core Concepts 2017
Core Concepts 2016

Core Concepts 2015

Core Concepts 2014

Core Competencies 2013

Core Competencies 2012

The Rodent Kidney Physiology/Injury Workshop
This annual workshop is held on the UCSD campus.  Led by Dr. Volker Vallon, faculty from UCSD and UAB organize an annual workshop designed to practice animal handling and phenotyping techniques for commonly used methods to study kidney function in the rat and mouse.  The format includes lectures (about 2 hours a day), demonstrations and hand-on practical training (about 6 hours a day).  Participants received a detailed workshop folder including all workstation handouts and lecture slides. This workshop is limited to 9 participants for the maximum interaction and time for training.  The next workshop will be April 17 – 21, 2017. Please see link below for application information.

Previous participants include graduate students, postdocs, research assistants, research associates, scientists, and faculty from 36 institutions from 9 countries (Australia, Belgium, Brazil, Canada, Czech Republic, Denmark, Puerto Rico, Switzerland and the USA): Aarhus University, Amgen Inc., AstraZeneca Pharmaceuticals, Duke University, Ferring Research Institute Inc., Georgia Health Sciences University, Institute for Clinical and Experimental Medicine Prague, Louisiana State University, Mater Research Institute, Medical College of Wisconsin, NorthShore University Health System, Ohio University, Universidade Estadual Paulista, University of Alabama at Birmingham, University of Alabama in Huntsville, University of Alberta, University of Arizona Tucson, University of California Merced, University of California San Diego, University of Colorado Boulder, University of Delaware, University of Florida, University of Leuven, University of Louisville, University of Mississippi, University of Pennsylvania, University of Pittsburgh, University of Puerto Rico, University of Southern California, UTHSC at Houston, University of Texas Southwestern, University of Toledo, University of Zurich, Wayne State University, Weis Center for Research and Write State University.

Rodent Kidney Physiology / Injury Workshop 2017

Rodent Kidney Physiology / Injury Workshop 2016

Rodent Kidney Physiology / Injury Workshop 2015

Rodent Kidney Physiology / Injury Workshop 2014

Rodent Kidney Physiology / Injury Workshop 2013
Rodent Kidney Physiology / Injury Workshop 2012
Rodent Kidney Physiology / Injury Workshop 2011

Flow Cytometry Workshop
This workshop is designed to provide researchers in nephrology with a basic working knowledge of primary methods of recovery and analysis of intra-renal leukocytes with an emphasis on flow cytometry.  By the end of the course, it is expected that participants will be able to isolate viable intra-renal leukocytes and analyze them by multi-color flow cytometry. They will have acquired the basic knowledge necessary to design a workable panel of antibodies, have familiarity with the operation of a flow cytometer and how to analyze data from an experiment. Methods of cell sorting will also be addressed.

Flow Cytometry Workshop 2017


Student Training


 The Summer Students Training Program for Medical Students

This is a three-month mentored research experience for medical students during the summer between the first and second year of study.  Funding for this program was made possible by a supplemental award from NIDDK and successfully renewed in 2013 for a third year.  Approximately 80% of the student's time is spent in the laboratory or the clinical research setting and the remaining 20% in scquiring the methodological training in clinical and translational research.  Trainees also participate in a course that focuses on scientific misconduct, the mentor-trainee relationship, scientific record keeping, data ownership, authorship, peer review, reporting results in articles, conflict of interest, compliance issues, scientific integrity, the use of experimental animals, and use of humans in biomedical experimentation.

Some of our Faculty Interests:

Anupam Agarwal, MD Professor, Department of Medicine - Division of Nephrology

  • Mechanisms of Acute Kidney Injury

David Allison, PhD, Professor, Department of Nutrition Sciences - School of Health Profession

  • Obesity
  • calroic restriction
  • longevity
  • statistical methods
  • research rigor

Mark Bevensee, PhD Associate Professor, Department of Cell, Developmental and Integrative Biology

  • cellular and molecular physiology of intracellular pH in kidney function
  • acid-base transporters and ion channels of the degenerins family contributions to kidney disease

Subhashini Bolisetty, PhD Assistant Professor, Department of Medicine - Division of Nephrology

  • ferritin mediated cytoprotection and cross-talk between tubules and immune cells during injury

Lisa Curtis, PhD Assistant Professor, Department of Medicine - Division of Nephrology

  • Cellular sources of epithelial repair in AKI
  • Sex difference in heme oxygenase-1 in the kidney
  • Pathobiology of AKI in the aging kidney

Orlando Gutierrez, MD Associate Professor, Department of Medicine - Division of Nephrology

  • population studies of renal disease

Edward Inscho PhD, Department of Medicine-Division of Nephrology

  • Control of renal hemodynamics at the microcirculatory level
  • role of renal P2 receptors TLR4 and endothelin system in controlling pre- and post-glomerular resistance

Eric Judd, MD Assistant Professor, Department of Medicine - Division of Nephrology

  • Validity of urine osmolality measurement
  • Ultrasound-assessment of volume in dialysis patients in the ICU

Roslyn Mannon, MD Professor, Department of Medicine - Division of Nephrology

  • mechanisms of late kidney allograft failure, fibrosis and tubular injury
  • immunologic and nonimmunologic factors in kidney injury models coupled with human tissue

Caroline Marshall, MD Assistant Professor, Department of Medicine - Division of Nephrology

  • elucidating disease-specific theapies for diabetic nephropathy
  • insulin receptor signaling pathway involvement in glomerular basement membrane thickening

Tanecia Mitchell, PhD Assistant Professor, Department of Urology

  • The role of mitochondrial and oxidative stress in immune cells in urological disorders
  • effect of dietary oxalate on immune cell function in kidney stone disease
  • role of monocytes and lymphocytes in interstitial cystitis/painful bladder syndrome

Joanne Murphy-Ullrich PhD Professor, Department of Pathology

  • Role of the endoplasmic reticulum and calcium regulatory protein, calreticulin, in regulating TGF-beta signaling in diabetic nephropathy
  • Validation of antagonists of the thrombospondin1-TGF-beta pathway for treatment of diabetic nephropathy

David Pollock, PhD Professor, Department of Medicine - Division of Nephrology

  • Elucidate the physiological mechanisms that regulate sodium balance that impact salt-dependent hypertension, diabetes and obesity

Jennifer Pollock, PhD Professor, Department of Medicine - Division of Nephrology

  • mechanisms of salt-sensitive hypertension and endothelial dysfunction in renal tubular and vascular systems
  • origins of disease with determinations of how early life stress affects the vasculature in adulthood

Rakesh Patel, PhD, Professor, Department of Pathology

  • Trauma-Hemmorrhage and Transfusion related Acute Kidney Injury

 Alexander Szalai, PhD Professor, Department of Medicine - Division of Clinical Immunology and Rheumatology

  • innate immunity in health and propagation of disease
  • CRP's role in renal disease (AKI, PKD, Lupus Nephritis and fistula failure

Lectures

The Annual AKI Symposium

"Changing Paradigms in Acute Kidney Injury: From Mechanisms to Management" 
UCSD med center 2
This annual Symposium takes place each year in San Diego and is part of the Annual CRRT Conference.  In 2016 the UAB/UCSD O'Brien Center will again sponsor this event in San Diego.


Acute Kidney Injury is a rapidly evolving area where several advances have been made in understanding the mechanisms and pathways of AKI and its effects on other organs.  Recent identification of biomarkers has provided new tools and techniques to characterize this disorder, this O'Brien Center sponsored workshop provides a comprehensive review of the most recent developments in the field and describes emergin knowledge from basic and translational research.

Sessions are approximately 1 hour, 20 minutes, media includes video, audio and slides. Please note that not all individual presentations given at the symposium are available for viewing.


2017 Session Information
  1. Molecules, Mechanisms and Targets
  2. Of Mice and Men:Harmonizing Human and Animal AKI
  3. Bench to Bedside: Translating Discoveries to Clinical Care
  4. Controvesies in AKI

2016 Session Information
  1. Molecules, Mechanisms and Targets
  2. Harmonizing Human and Animal AKI: Results from ADQI 13
  3. Bench to Bedside: Translating Discoveries to Clinical Care
  4. Controversies in AKI

2015 Plenary Session Multimedia
  1. Molecules, Mechanisms and Targets
  2. Harmonizing Human and Animal AKI: Results from ADQI 13
  3. Bench to Bedside: Translating Discoveries to Clinical Care
  4. Controversies in AKI

2014 Plenary Session Multimedia

  1. Molecules, Mechanisms and Targets
  2. Of Mice and Men: Translational Research in AKI
  3. Improving OUtcomes in AKI: What Should we Focus on?
  4. Biomarkers in AKI: Are we Ready for Prime Time?

2013 Plenary Session Multimedia

  1. Molecules, Mechanisms, and Targets.
  2. Translational Research: Bedside to Bench and Back
  3. Of Mice and Men: Developing Relevant Models for Translational Research
  4. Tools to Characterize Human AKI

2012 Plenary Session Multimedia

  1. Molecules, Mechanisms, and Targets.
  2. Translational Research: Bedside to Bench and Back
  3. Pre-Clinical Models for Translational Research in AKI
  4. Enhancing Clinical and Translational Research in AKI
  5. Tools to Characterize Human AKI