Pulm_Div_Gaggar

 

Associate Professor of Medicine

Director, UAB Cystic Fibrosis Inflammation Group

Co-Director, Pulmonary Biospecimen Sample Repository

Division of Pulmonary, Allergy & Critical Care Medicine
1530 3rd Avenue So, THT-422
University of Alabama at Birmingham
Birmingham, AL 35294

Board Certifications
2003, American Board of Internal Medicine

2005, American Board of Internal Medicine, Pulmonary Diseases
2006, American Board of Internal Medicine, Critical Care Medicine

Medical School:  University of Michigan School of Medicine, 2000
University of Alabama - Birmingham, 2007 (PhD)

Internship:  University of Alabama - Birmingham, 2000-2001

Residency:  University of Alabama - Birmingham, 2001-2003

Fellowship:  University of Alabama - Birmingham, Pulmonary & Critical Care Medicine, 2003-2006
University of Alabama - Birmingham, Lung Transplant, 2005-2006 

Contact Information

Campus Address:

 THT 422

Academic Office location:

 MCLM 760

Office Phone:

 (205) 934-6369

Office Fax (Academic):

 (205) 934-1446

TKC Clinic Phone:

 (205) 801-7545

TKC Clinic Fax:

 (205) 802-8231

Email Address:

 agaggar@uab.edu

Beeper #:

 8377

Office Assistant:
Brynn Sharp
brynnsharp@uab.edu
Phone: (205) 934-4304
Fax: (205) 934-1446

Brief Bio
Dr. Gaggar obtained his medical degree from the University of Michigan in 2000 as a member of the prestigious Inteflex program.  He then moved to Birmingham, AL where he completed his internship and residency in internal medicine at the University of Alabama at Birmingham (UAB) in 2003.  Following residency training, he began fellowship training at UAB in pulmonary and critical care medicine. During the research phase of his fellowship training, he worked in the laboratories of Dr. JP Clancy (Chief, Pediatric Pulmonology) and Dr. J. Edwin Blalock (Professor, Department of Medicine).  He completed his fellowship in 2006, with special emphasis in cystic fibrosis and lung transplantation. 

The following year, Dr. Gaggar completed a PhD in Molecular and Cellular Physiology at UAB.  Dr. Gaggar was invited to joined the UAB Division of Pulmonary, Allergy & Critical Care Medicine in 2006 as instructor in medicine.  In July 2007 he was promoted to his current position as Assistant Professor of Medicine. He currently serves as a director of the Pulmonary Biospecimen Repository and the Cystic Fibrosis Inflammation Group at UAB.   He continues to see patients as both an inpatient physician and in the clinic setting.  In addition, his laboratory program continues to investigate the roles of proteases in lung disease.

Clinical Interests 
Dr. Gaggar currently sees patients after lung transplantation and individuals with cystic fibrosis at University Hospital.  He also holds a staff position at the Birmingham VA Medical Center (BVAMC) where he sees individuals with chronic obstructive lung disease (COPD).  In addition, he serves as an attending physician at both the UAB and the BVAMC intensive care units.

Academic & Research Interests
Dr. Gaggar's laboratory interests focus on the roles proteases play in modulation of lung disease.  Dr. Gaggar utilizes a combination of cell-based systems, unique murine models, and clinical specimens, leading to research which is truly "translational" in nature.  The Gaggar lab's interests focus on 3 major arenas: proteases and neutrophilic airway inflammation, proteases and ion transportation, and the Regulation of Surfactant Protein D by Airway Proteases.

Recently, Dr. Gaggar's laboratory and Dr. J. Edwin Blalock's laboratory have worked together to describe the proteolytic pathways involved in the generation of a novel neutrophil chemoattractant, proline-glycine-proline (PGP).  Dr. Gaggar's group has shown that this chemoattractant is generated by the cleavage of collagen by matrix metalloprotease (MMP)-8 and MMP-9, in conjunction with a novel serine protease, prolyl endopeptidase (PE). 
Dr. Gaggar's group has also highlighted the relative contribution of PGP in development of BOS, demonstrating for the first time the impact this peptide might play in clinical lung disease.  Ongoing efforts are now being focused in further delineation of the biological roles PGP may induce in the airway beyond neutrophil recruitment.

Key Publications
Gaggar A,
Olman, M.  Biologic markers of mortality in acute lung injury. Clin Chem Acta 372, 24-32, 2006.


Gaggar A
, Li Y, Weathington N, Winkler M, Jackson PL, Blalock JE, and Clancy JP.  Matrix metalloprotease-9 dysregulation in lower airway secretions of cystic fibrosis patients.  AJP - Lung Cellular and Molecular Physiology. 293 (1): L96-L104, 2007


Gaggar A, Jackson P, Noerager B, OReilly PJ, Mcquaid DB, Rowe SM, Clancy JP, Blalock JE. A novel proteolytic cascade generates an extracellular derived neutrophil chemoattractantJournal of Immunology  180: 5662-5669, 2008.

Hardison M, Galin FS, Calderon C, Jackson PL, Blalock JE, Gaggar A. The presence of a matrix-derived neutrophil chemoattractant seen in bronchiolitis obliterans syndrome after lung transplantation, Journal of Immunology 182(7), 4423-4431, 2009.

O'Reilly PJ, Gaggar A, Blalock JE.  Interfering with extracellular matrix degradation to blunt inflammation.  Current Opinion Pharmacology 8: 242-248, 2008.

Please click here for Dr. Gaggar's complete publications listing.

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