Endowed Professor in Lung Immunology
Assistant Dean for Research Administration, School of Medicine and Office of the Senior Provost
Areas of Interest
Lung Immunolgy and Host Defense
Dr. Claude H. (Chad) Steele III was born in Pensacola, Florida in 1972 and his family moved to northeast Louisiana the following year. Dr. Steele attended the University of Louisiana at Monroe (formerly Northeast Louisiana University), receiving a Bachelor's degree in Chemistry in 1995. After an 18 month stint as an industrial chemist, Dr. Steele entered graduate school in the Department of Microbiology at Louisiana State University Health Sciences Center-New Orleans, earning a Masters degree in December 1998, followed by a Doctorate in December 2000, both under the mentorship of Dr. Paul Fidel. Dr. Steele remained at LSUHSC for his post-doctoral fellowship, conducting lung host defense research in the laboratories of Dr. Jay Kolls and Dr. Judd Shellito. In July 2003, Dr. Steele was recruited as faculty to the Department of Pediatrics at the University of Pittsburgh, where he remained until June 2007. In July 2007, Dr. Steele was recruited to join the faculty at the University of Alabama at Birmingham, in the Division of Pulmonary, Allergy & Critical Care Medicine, where he is currently a tenured Professor of Medicine.
Research in Dr. Steele's Laboratory of Lung Immunology and Host Defense is focused on understanding innate and adaptive immune responses against opportunistic fungal pathogens that cause life-threatening lung infections in immunocompromised individuals with such diseases as HIV, COPD and leukemia. Dr. Steele's research on the fungal pathogen Pneumocystis carinii has uncovered a role for alternative macrophage activation, termed M2a, that is associated with more efficient elimination of P. carinii from the lungs. Dr. Steele's lab is currently characterizing multiple M2a-associated innate host defense molecules in an effort to understand what influences alveolar macrophage effector responses against P. carinii.
In a new project, Dr. Steele’s lab is investigating how Th2 responses are generated during P. carinii lung infection and how B cells affect the CD4 T cell phenotype during infection. In other projects, Dr. Steele's research team has discovered an essential role for a myeloid-associated fungal recognition receptor, Dectin-1, in lung innate immune responses to the fungal pathogen Aspergillus fumigatus. Dectin-1, which recognizes beta-glucan carbohydrates found in the cell wall of all medically-important fungi, controls the production of multiple inflammatory cytokines, including IL-17A and IL-22. In invasive aspergillosis (IA), Dr. Steele’s lab has shown that IL-17A and IL-22 are required for protection against infection, yet during A. fumigatus-associated asthma (AFAA), IL-17A and IL-22 function in an immunopathogenic role and contributes to asthma severity. Dr. Steele's lab is currently focusing on the lung cell sources of IL-17A and IL-22 during IA and AFAA, which pathways drive the development of these cell populations and the downstream IL-17A- and IL-22-associated mechanisms that promote elimination of A. fumigatus from the lungs vs. those driving deleterious responses during fungal asthma.
Education & Training
Department of Microbiology at Louisiana State University Health Sciences Center-New Orleans, New Orleans, LA
Ph: (205) 996-9599
Fax: (205) 934-1721