Herb Chen Color Cropped 3397 Rieger web

Chairman, Department of Surgery
Professor of Surgery
Professor of Biomedical Engineering
Fay Fletcher Kerner Endowed Chair
Surgeon-in-Chief, UAB Hospital and Health System
Senior Advisor, UAB Comprehensive Cancer Center

Areas of Interest
thyroid and parathyroid surgery, minimally invasive radioguided parathyroidectomy, adrenal surgery, endocrine surgery, neuroendocrine cancer biology

Biography

In October 2015, Dr. Herbert Chen was named as the new Chairman of the Department of Surgery. A native of Wisconsin, Chen received his undergraduate degree from Stanford University and began his medical education at the Duke University School of Medicine, graduating in 1992. He completed his surgical residency in general surgery at Johns Hopkins in 1999, along with a postdoctoral research fellowship in 1997 and a surgical oncology and endocrinology fellowship in 2000. Dr. Chen came to UAB from the University of Wisconsin, where he was the Layton F. Rikkers, M.D., Chair in Surgical Leadership, chair of the Division of General Surgery, vice chair of Research for the Department of Surgery and professor in the departments of Surgery, Biomedical Engineering and Pediatrics. Dr. Chen is a specialist in endocrine surgery, a funded surgeon scientist, and a dedicated educator. Dr. Chen is an Associate/Section Editor for Annals of Surgery, Annals of Surgical Oncology, Scientific American Surgery, The Oncologist, and Journal of Surgical Research, and serves on six other editorial boards. He is also the Past-President of Association for Academic Surgery, the current Secretary-Treasurer for Surgical Biology Club II, and the current President-Elect for the Society of Clinical Surgery. Dr. Chen has mentored over 100 faculty, post-doctoral fellows, residents, medical students, and undergraduates in his lab.

Clinical and Research Interests

Dr. Chen’s clinical interests include endocrine and neuroendocrine disease with a focus on minimally invasive endocrine surgery. He has one of the largest experiences with radioguided parathyroidectomy (MIRP), and performs high volume thyroid and adrenal surgery. Dr. Chen’s laboratory focuses on the role of cellular signaling pathways in the differentiation and growth of neuroendocrine (NE) tumors including carcinoid, pancreatic islet cell, pheochromocytoma, and medullary thyroid cancer.

Selected Publications

Yu X, Jaskula-Sztul R, Georgen MR, Aburjania Z, Somnay YR, Leverson G, Sippel RS, Lloyd RV, Johnson BP, Chen H. Notch1 Signaling Regulates the Aggressiveness of Differentiated Thyroid Cancer and Inhibits SERPINE1 Expression. Clinical Cancer Research. (in press).

Jaskula-Sztul R, Eide J, Tesfazghi S, Dammalapati A, Harrison A, Yu X, Scheinebeck C, Winston-McPherson G, Kupcho KR , Robers MB, Hundal AK, Tang W, Chen H. Tumor-suppressor role of Notch3 in Medullary Thyroid Carcinoma revealed by genetic and pharmacological induction. Molecular Cancer Therapeutics 2015; 14: 1-14. PMCID: PMC4326595

Pozo K, Castro-Rivera E, Tan C, Plattner F, Schwach G, Siegl V, Meyer D, Guo A, Gundara J, Mettlach G, Richer E, Guevara LA, Ning L, Tsai L, Antich P, Sidhu S, Robinson BG, Chen H, Nwariaku FE, Pfragner R, Richardson JA, Bibb JA. The Role of Cdk5 in Neuroendocrine Thyroid Cancer. Cancer Cell 2013; 24: 499-511.

Lou I, Foley D, Odorico SK, Leverson G, Schneider DF, Sippel RS, Chen H. How well does renal transplantation cure hyperparathyroidism? Annals of Surgery (in press). NIHMSID# 690976

Oltmann SC, Chen H. Minimally Invasive Radioguided Parathyroidectomy. Curr Surg Rep. DOI 10.1007/s40137-012-0001-y

Murray SE, Sippel RS, Chen H. Incidence of concomitant hyperparathyroidism in patients with thyroid disease requiring surgery. Journal of Surgical Research 2012; 178: 264-267. PMCID: PMC3408846

Mazeh H, Khan Q, Schneider DF, Schaefer S, Sippel RS, Chen H. Same day thyroidectomy program:  Eligibility and safety evaluation.  Surgery 2012; 6:1133-1141. PMID: 23158183

Schneider DF, Mazeh H, Sippel RS, Chen H. Is Minimally Invasive Parathyroidectomy Associated with Higher Recurrence Compared to Bilateral Exploration? Analysis of over 1000 cases. Surgery 2012; 6: 1008-1015. PMCID: PMC3501613

Chen H, Mack E, Starling JR. A Comprehensive Evaluation of Peri-operative Adjuncts during Minimally Invasive Parathyroidectomy: Which is Most Reliable? Ann Surg 2005; 242: 375-383.

Chen H, Mack E, Starling JR. Radioguided Parathyroidectomy is Equally Effective for Both Adenomatous and Hyperplastic Glands. Ann Surg. 2003; 238: 332-338.

Education

Undergraduate
Stanford University

Medical School
Duke University

Fellowship
Johns Hopkins University 
Research

Residency
Johns Hopkins University
General Surgery

Fellowship
Johns Hopkins University
Surgical Oncology, Endocrine Surgery

Honors and Awards 

McEwen Lecture, University of Kansas (2016)
Danely P. Slaughter Memorial Lecture, Presence Saint Francis (2015)
President-Elect, Society of Clinical Surgery (2014-2016)
Byers “Bud” Shaw Lecture, University of Nebraska (2014)
Caring for Carcinoid Foundation-AACR Award for Carcinoid Tumor and Pancreatic Neuroendocrine Tumor Research (2014)
Scott Woods Endowed Lecture, Wayne State University (2013)
Joseph B. Priestly Lecture, Throckmorton Surgical Society (2013)
Charles Getz Lecture, University of Maryland (2013)
Gregory B. Bulkley Lecture, Johns Hopkins University (2012)
Moses Gunn Lecture, University of Michigan (2012)
Rosen-Rasch Lecture, University of Toronto (2011)
Robert Ravdin Lecture, University of Pennsylvania (2011)
Dean’s Award for Excellence in Medical Student Research Mentorship (2011)
Recorder, American Association of Endocrine Surgeons (2011-2014)
Murray Brennan Distinguished Lecture, Memorial Sloan Kettering Cancer Center (2011)
American Society of Clinical Investigation (2011)
American Cancer Society MEN2 Thyroid Cancer Professorship (2011-2015)
Treasurer, Society of Clinical Surgery (2010-2014)
Secretary-Treasurer, Surgical Biology Club II (2010-present)
Thurston Adams Lecture, University of Maryland (2010)
John Daane Lecture, University of South Florida (2009)
President, Association for Academic Surgery (2008-2009)
Gardner Smith Lecture, Johns Hopkins Medical Institutions (2008)
Best Doctors in America (2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015)
Midwest Surgical Association Best Paper by a New Member Award (2007)
Society of Surgical Oncology Clinical Investigator Award (2007)
Australia and New Zealand Chapter of the American College of Surgeons Traveling Fellowship (2007)
Carcinoid Cancer Foundation Research Achievement Award (2006)Vilas Associate Award (2006
Herman Shapiro Lectureship, University of Wisconsin (2005)
Central Surgical Association Best Paper by a New Member Award (2005)
Recorder, Association for Academic Surgery (2004-2007)
James IV Association of Surgeons Traveling Fellow for the United States (2004)
Leon E. Sample Memorial Lecture, Yale University (2003)
George H.A. Clowes, Jr. MD, FACS, Memorial Research Career Development Award of the American College of Surgeons (2003)
University of Wisconsin Medical Alumni Association Clinical Science Teaching Award (2002)
American Surgical Association Foundation Fellowship Award (2001)
Howard Hughes Medical Institute Faculty Development Award (2001)
Society for Surgery of the Alimentary Tract Young Clinician Travel Award (2001)
American Cancer Society Institutional Research Award (2000)
James Ewing Oncology Fellowship Award for Basic Research (2000)

Contact Information

Email
herbchen@uab.edu

Phone
205-934-3333

Campus Address
Boshell Building, Suite 502