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Personnel

Jeevan Prasain, PhD

Jeevan Prasain, PhD

Associate Professor of Pharmacology and Toxicology
University of Alabama at Birmingham
Department of Pharmacology & Toxicology
BBRB 714 (UAB OneCard access required)
845 19th St S
Birmingham, AL 35205
Tel: (205) 996-2612
E-mail: Jprasain@uab.edu

Education:

M.Sc. in Chemistry, Tribhuvan University, Nepal; Ph.D. in Pharmaceutical Chemistry, Toyama Medical & Pharmaceutical University, Japan; Postdoctoral Fellow in Protein Chemistry, Biotechnology Research Institute, Montreal, Canada; Postdoctoral Fellow in Antibiotics Research, Inst. Phys. Chem Res., Japan; Postdoctoral Fellow in Botanicals/LC-MS at the University of Alabama at Birmingham.

Research focus

Metabolomics/lipidomics, especially delineation of the Cox-independent PG synthesis mechanism, structure identification of signaling lipids/oxidized lipids using untargeted and targeted lipidomics. Bioactive dietary natural products in the prevention of chronic diseases such as diabetes and cancers, their metabolisms, and bioavailability assessment using liquid chromatography tandem mass spectrometry (LC-MS/MS).

Publications

2022- 2023 Publications
  1. Ekta Tiwary, Taylor F Berryhill, Landon Wilson, Stephen Barnes, Jeevan K Prasain, J Michael Wells
    LC-MS/MS method for proline-glycine-proline and acetylated proline-glycine-proline in human plasma
    J Chromatogr B Analyt Technol Biomed Life Sci. 2023 Jul 5;1228:123815. PMID: 37453387 doi: 10.1016/j.jchromb.2023.123815 Online ahead of print.
  2. Prasain JK, Wilson LS, Grubbs C, Barnes S.
    Gamma-ray Irradiation of Rodent Diets Alters the Urinary Metabolome in Rats with Chemically Induced Mammary Cancer.
    Metabolites. 2022 Oct 16;12(10):976. [doi:10.3390/metabo12100976] PMID: 36295878
2021 Publications
  1. Ekta Tiwary, Muhan Hu, Jeevan K. Prasain
    Sperm-Guiding Unconventional Prostaglandins in C. elegans: Synthesis and Signaling
    Metabolites 2021, 11(12), 853; 10.3390/metabo11120853
  2. Jeevan K. Prasain, Stephen Barnes, J. Michael Wyss
    Kudzu isoflavone C-glycosides: Analysis, biological activities, and metabolism
    Food Frontiers. First published: 06 August 2021. [doi: 10.1002/fft2.105]
  3. Hu M, Tiwary E, Prasain JK, Miller M, Serra R.
    Mechanisms of TGFß in prostaglandin synthesis and sperm guidance in Caenorhabditis elegans.
    Dev Dyn. 2021 Jul;250(7):932-942. [doi: 10.1002/dvdy.296] Epub 2021 Jan 23. PMID: 33410237
2020 Publications
  1. Muhan Hu, David Crossman, Jeevan K Prasain, Michael A Miller, Rosa A Serra
    Transcriptomic Profiling of DAF-7/TGFβ Pathway Mutants in C. elegans
    Genes (Basel). 2020. [doi: 10.3390/genes11030288] [PMID: 32182864] [PMCID: PMC7140792]
  2. Jeevan K. Prasain, Stephen Barnes
    Cranberry polyphenols‐gut microbiota interactions and potential health benefits: An updated review
    Food Frontiers. Dec 30, 2020. [doi: 10.1002/fft2.56]

2019 Publications
  1. Prasain, Jeevan K., Grubbs, Clinton, Barnes, Stephen.
    Cranberry anti-cancer compounds and their uptake and metabolism: An updated review.
    Journal of Berry Research, vol. Pre-press, no. Pre-press, pp. 1-10, 2019. [DOI: 10.3233/JBR-180370]
  2. Ekta Tiwary, Muhan Hu, Michael A. Miller & Jeevan K. Prasain.
    Signature profile of cyclooxygenase-independent F2 series prostaglandins in C. elegans and their role in sperm motility.
    Sci Rep. 2019 Aug 13;9(1):11750. [doi: 10.1038/s41598-019-48062-y]
  3. Prasain, Jeevan K., Grubbs, Clinton, Barnes, Stephen.
    Cranberry anti-cancer compounds and their uptake and metabolism: An updated review.
    Journal of Berry Research, vol. Pre-press, no. Pre-press, pp. 1-10, 2019. [DOI: 10.3233/JBR-180370]
2018 Publications
  1. Hough KP, Wilson LS, Trevor JL, Strenkowski JG, Maina N, Kim YI, Spell ML, Wang Y, Chanda D, Dager JR, Sharma NS, Curtiss M, Antony VB, Dransfield MT, Chaplin DD, Steele C, Barnes S, Duncan SR, Prasain JK, Thannickal VJ, Deshane JS.
    Unique Lipid Signatures of Extracellular Vesicles from the Airways of Asthmatics.
    Sci Rep. 2018 Jul 9;8(1):10340. [doi: 10.1038/s41598-018-28655-9] [PMID: 29985427]

2017 Publications
  1. Pier B, Edmonds JW, Wilson L, Arabshahi A, Moore R, Bates GW, Prasain JK, Miller MA
    Comprehensive profiling of prostaglandins in human ovarian follicular fluid using mass spectrometry.
    Prostaglandins Other Lipid Mediat. 2017 Nov 9. pii: S1098-8823(17)30098-9. [doi: 10.1016/j.prostaglandins.2017.11.001] [Epub ahead of print] [PMID: 29129796]

  2. Prasain JK, Wilson LS, Arabshahi A, Grubbs C, Barnes S.
    Mass spectrometric evidence for the modification of small molecules in a cobalt-60-irradiated rodent diet.
    J Mass Spectrom. 2017 Aug;52(8):507-516. [doi: 10.1002/jms.3950] Erratum in: J Mass Spectrom. 2017 Oct;52(10 ):707.
    [ PMID: 28544323]

  3. Shamik Das, William P. Jackson, Jeevan K. Prasain, Ann Hanna, Sarah K. Bailey, J. Allan Tucker, Sejong Bae, Landon S. Wilson, Rajeev S. Samant, Stephen Barnes & Lalita A. Shevde
    Loss of Merlin induces metabolomic adaptation that engages dependence on Hedgehog signaling.
    Scientific Reports 7, Article number: 40773 [doi:10.1038/srep40773]

2016 Publications
  1. Metabolomics - Fundamentals and Applications
    Edited by Jeevan K. Prasain, ISBN 978-953-51-2854-0, Print ISBN 978-953-51-2853-3, 214 pages,
    Publisher: InTech, Chapters published December 28, 2016 under CC BY 3.0 license [doi: 10.5772/62614] Edited Volume

  2. Singh A, Rahman T, Bartiss R, Arabshahi A, Prasain J, Barnes S, Musteata FM, Sellati TJ.
    Lipoxin A4, a 5-lipoxygenase pathway metabolite, modulates immune response during acute respiratory tularemia.
    J Leukoc Biol. 2016 Sep 14. pii: jlb.4A0815-365RR. [Epub ahead of print] [PMID: 27630217]

  3. Jeevan K. Prasain, Rajani Rajbhandari, Adam B. Keeton, Gary A. Piazzab and Stephen Barnes.
    Metabolism and growth inhibitory activity of cranberry derived flavonoids in bladder cancer cells.
    Food Funct., 2016, Advance Article, [doi: 10.1039/C6FO00499G]

  4. Barnes S, Benton HP, Casazza K, Cooper SJ, Cui X, Du X, Engler J, Kabarowski JH, Li S, Pathmasiri W, Prasain JK, Renfrow MB, Tiwari HK.
    Training in metabolomics research. I. Designing the experiment, collecting and extracting samples and generating metabolomics data.
     J Mass Spectrom. 2016 Jul;51(7):461-75. [doi: 10.1002/jms.3782] [PMID: 27434804]

2015 Publications
  1. Jeevan K. Prasain, Landon Wilson, Hieu D. Hoang, Ray Moore and Michael A. Miller
    Comparative Lipidomics of Caenorhabditis elegans Metabolic Disease Models by SWATH Non-Targeted Tandem Mass Spectrometry
    Metabolites 2015, 5(4), 677-696; [doi:10.3390/metabo5040677]
2014 Publications
  1. Wilson L, Arabshahi A, Simons B, Prasain JK, Barnes S.
    Improved high sensitivity analysis of polyphenols and their metabolites by nano-liquid chromatography-mass spectrometry.
    Arch Biochem Biophys. 2014 Oct 1;559:3-11. [doi: 10.1016/j.abb.2014.06.014] [PMID: 24967696]

  2. McKnight K, Hoang HD, Prasain JK, Brown N, Vibbert J, Hollister KA, Moore R, Ragains JR, Reese J, Miller MA.
    Neurosensory perception of environmental cues modulates sperm motility critical for fertilization.
    Science. 2014 May 16;344(6185):754-7. [doi: 10.1126/science.1250598] [PMID: 24833393]

  3. Legette LL, Prasain J, King J, Arabshani A, Barnes S, Weaver CM.
    Pharmacokinetics of Equol, a Soy Isoflavone Metabolite, Changes with Form of Equol (Dietary vs. Intestinal Production) in Ovariectomized Rats.
    J Agric Food Chem. 2014 Feb 12;62(6):1294-300. [doi: 10.1021/jf400097m] Epub 2014 Jan 29. [PMID: 24446705]

2013 Publications
  1. Cutts JK, Peavy TR, Moore DR, Prasain J, Barnes S, Kim H.
    Ovariectomy lowers urine levels of unconjugated (+)-catechin, (-)-epicatechin, and their methylated metabolites in rats fed grape seed extract.
    Horm Mol Biol Clin Investig. 2013 Dec;16(3):129-38. [doi: 10.1515/hmbci-2013-0044] [PMID: 25436866]

  2. Han SM, El Oussini H, Scekic-Zahirovic J, Vibbert J, Cottee P, Prasain JK, Bellen HJ, Dupuis L, Miller MA.
    VAPB/ALS8 MSP Ligands Regulate Striated Muscle Energy Metabolism Critical for Adult Survival in Caenorhabditis elegans.
    PLoS Genet. 2013 Sep;9(9):e1003738. [PMID: 24039594] [doi: 10.1371/journal.pgen.1003738] Epub 2013 Sep 5.

  3. Whitehouse-Tedd K, Cave N, Ugarte C, Tucker L, Prasain JK, Arabshahi A, Barnes S, Hendriks W, Thomas D.
    Isoflavone metabolism in domestic cats (Felis catus): comparison of plasma metabolites detected after ingestion of two different dietary forms of genistein and daidzein.
    J Anim Sci. 2013 Mar;91(3):1295-306. [PMID: 23307849]

  4. Ulasova E, Perez J, Hill BG, Dubuisson JG, Bradley WE, Garber DW, Landar A, Barnes S, Prasain J, Parks DA, Dell’Italia LJ, Darley-Usmar VM.
    Quercetin prevents left ventricular hypertrophy in the Apo E knockout mouse.
    Redox Biol. 2013 Jul 16;1(1):381-6. [PMID: 24024175]

  5. Jeevan K. Prasain, Hieu D. Hoang, Johnathan W. Edmonds, Michael A. Miller
    Prostaglandin Extraction and Analysis in Caenorhabditis elegans
    Advances in Bioinformatics, J. Vis. Exp. (76), e50447 (2013) [doi:10.3791/50447]

  6. Hieu D. Hoang, Jeevan K. Prasain, Dixon Dorand, Michael A. Miller
    A Heterogeneous Mixture of F-Series Prostaglandins Promotes Sperm Guidance in the Caenorhabditis elegans Reproductive Tract
    PLoS Genet 9(1): e1003271 [doi:10.1371/journal.pgen.1003271]

  7. Jeevan K. Prasain, Alireza Arabshahi, Pam R. Taub, Scott Sweeney, Ray Moore, J. Daniel Sharer, Stephen Barnes.
    Simultaneous quantification of F2-isoprostanes and prostaglandins in human urine by liquid chromatography tandem-mass spectrometry
    Journal of Chromatography B. Volumes 913–914, 15 January 2013, Pages 161–168 doi: 10.1016/j.jchromb.2012.12.009.
2012 Publications
  1. Prasain JK, Peng N, Rajbhandari R, Wyss JM.
    The Chinese Pueraria root extract (Pueraria lobata) ameliorates impaired glucose and lipid metabolism in obese mice.
    Phytomedicine. 2012 Nov 1. pii: S0944-7113(12)00353-4. doi: 10.1016/j.phymed.2012.09.017. [PMID: 23123226] [Epub ahead of print]

  2. He L, Kim T, Long Q, Liu J, Wang P, Zhou Y, Ding Y, Prasain J, Wood PA, Yang Q.
    Carnitine Palmitoyltransferase-1b (CPT1b) Deficiency Aggravates Pressure-Overload-Induced Cardiac Hypertrophy due to Lipotoxicity.
    Circulation. 2012 Aug 29. [Epub ahead of print] [PMID: 22932257]

  3. Edited by: Jeevan K. Prasain
    Tandem Mass Spectrometry - Applications and Principles
    ISBN 978-953-51-0141-3, Hard cover, 794 pages
    Publisher: InTech, Free Online Book
    Publication date: February 2012

2011 Publications
  1. Whitehouse-Tedd KM, Cave NJ, Ugarte CE, Waldron LA, Prasain JK, Arabshahi A, Barnes S, Thomas DG.
    Dietary isoflavone absorption, excretion, and metabolism in captive cheetahs (Acinonyx jubatus).
    J Zoo Wildl Med. 2011 Dec;42(4):658-70. [PMID: 22204061] [doi:10.1638/2011-0060.1]

  2. Frölich MA, Arabshahi A, Katholi C, Prasain J, Barnes S.
    Hemodynamic characteristics of midazolam, propofol, and dexmedetomidine in healthy volunteers. J Clin Anesth. 2011 May;23(3):218-23. [PMID: 21570617]

  3. Edmonds JW, McKinney SL, Prasain JK, Miller MA.
    The gap junctional protein INX-14 functions in oocyte precursors to promote C. elegans sperm guidance.
    Dev Biol. 2011 Aug 25. [Epub ahead of print] [PMID: 21889935]

  4. Barnes S, Prasain J, D'Alessandro T, Arabshahi A, Botting N, Lila MA, Jackson G, Janle EM, Weaver CM.
    The metabolism and analysis of isoflavones and other dietary polyphenols in foods and biological systems.
    Food Funct. 2011 May 25;2(5):235-44. [PMID: 21779561]

  5. Rajbhandari, R, Peng, N, Moore, DR, Arabshahi, A, Wyss, JM, Barnes S, Jeevan K. Prasain JK.
    Determination of cranberry phenolic metabolites in rats by liquid chromatography-tandem mass spectrometry.
    J Agric Food Chem, 2011, 59(12):6682-8. [PMID: 21634376]

  6. Byer SJ, Eckert JM, Brossier NM, Clodfelder-Miller BJ, Turk AN, Carroll AJ, Kappes JC, Zinn KR, Prasain JK, Carroll SL.
    Tamoxifen inhibits malignant peripheral nerve sheath tumor growth in an estrogen receptor-independent manner.
    Neuro Oncol. 2011 Jan;13(1):28-41. [PMID:21075781]

2010 Publications
  1. Edmonds JW, Prasain JK, Dorand D, Yang Y, Hoang HD, Vibbert J, Kubagawa HM, Miller MA.
    Insulin/FOXO Signaling Regulates Ovarian Prostaglandins Critical for Reproduction.
    Dev Cell. 2010 Dec 14;19(6):858-71. [PMID: 21145501]

  2. Prasain JK, Arabshahi A, Moore DR 2nd, Greendale GA, Wyss JM, Barnes S.
    Simultaneous determination of 11 phytoestrogens in human serum using a 2 min liquid chromatography/tandem mass spectrometry method.
    J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Apr 15;878(13-14):994-1002. Epub 2010 Mar 6. [PMID: 20346741]

  3. Prasain JK, Carlson SH, Wyss JM.
    Flavonoids and age-related disease: Risk, benefits and critical windows.
    Maturitas. 2010 Feb 22. [Epub ahead of print] [PMID: 20181448]
2009 Publications
  1. Pyle LC, Fulton JC, Sloane PA, Backer K, Mazur M, Prasain J, Barnes S, Clancy JP, Rowe SM.
    Activation of CFTR by the Flavonoid Quercetin: Potential Use as a Biomarker of ΔF508 CFTR Rescue
    Am J Respir Cell Mol Biol. 2009 Dec 30. [PMID: 20042712]

  2. Peng N, Prasain JK, Dai Y, Moore R, Arabshahi A, Barnes S, Carlson S, Wyss JM.
    Chronic dietary kudzu isoflavones improve components of metabolic syndrome in stroke-prone spontaneously hypertensive rats.
    J Agric Food Chem. 26;57(16):7268-73, 2009.. [PMID: 19938872]

  3. Prasain JK, Peng N, Dai Y, Moore R, Arabshahi A, Wilson L, Barnes S, Michael Wyss J, Kim H, Watts RL.
    Liquid chromatography tandem mass spectrometry identification of proanthocyanidins in rat plasma after oral administration of grape seed extract.
    Phytomedicine, 16(2-3):233-43, 2009. [PMID: 19095430]

  4. Prasain JK, Peng N, Moore R, Arabshahi A, Barnes S, Wyss JM.
    Tissue distribution of puerarin and its conjugated metabolites in rats assessed by liquid chromatography-tandem mass spectrometry.
    Phytomedicine, 16(1); 65-71, 2009. [PMID: 19027277]

2008 Publications
  1. Prasain JK, Arabshahi A, Moore R, Barnes S, Carroll SL.
    A liquid chromatography mass spectrometry assay for determination of PD168393, a specific and irreversible inhibitor of erbB membrane tyrosine kinases, in rat serum.
    Journal of Chromatogr B. 876(2): 219-224, 2008

  2. Prasain J.K., Jones, K., Moore, D.R., Barnes, S., Leahy, M., Roderick, R., Juliana, M.M. and Grubbs, C.J.
    Effect of cranberry juice concentrate on chemically-induced urinary bladder cancers.
    Oncology Reports 19: 1565-1570, 2008.

  3. Carlson, S., Peng, N., Prasain, J.K. and Wyss, J.M.
    The effects of botanical dietary supplements on cardiovascular, cognitive and metabolic function in males and females.
    Gender Medicine, 5: S76-S90, 2008.

  4. Peng, N., Prasain, J.K., Dai, Y., Carlson, S.H. and Wyss, J.M.
    Dietary kudzu root extract supplementation improves glucose tolerance and plasma lipid profiles in Spontaneously Hypertensive Rats (SHR) fed a basal, but not high, NaCl diet.
    Abstracts of Experimental Biology, 22:948.9, 2008.

  5. Carlson, S.H., Peng, N., Prasain, J.K., Dai, Y and Wyss, J.M.
    Kudzu root extract improves glycemic control in non-glucose-impaired mice.
    Abstracts of Experimental Biology, 22:949.12, 2008.

2007 Publications
  1. Prasain, J.K., Barnes, S.
    Metabolism and bioavailability of flavonoids in chemoprevention: current analytical strategies and future prospectus.
    Molecular Pharmaceutics. 4 (6), 846-864, 2007.

  2. Prasain J, Peng N, Acosta E, Moore R, Arabshahi A, Meezan E, Barnes S, Wyss, JM.
    Pharmacokinetic study of puerarin in rat serum by liquid chromatography tandem mass spectrometry.
    Biomedical Chromatography.
    Biomed Chromatogr. 21(4):410-4, 2007.

  3. Prasain, J.K., Reppert, A., Jones, K., Moore, D.R., II, Barnes, S., and Lila, M.A.
    Identification of isoflavone glycosides in Pueraria lobata cultures by tandem mass spectrometry.
    Phytochemical Analysis 18:50-59, 2007.

Pre 2007 Publications
  1. Barnes, S., Prasain, J.K., Wang, C-C., Moore, D.R., II.
    Applications of LC-MS in the study of the uptake, distribution, metabolism and excretion of bioactive polyphenols from dietary supplements.
    Life Sciences, 27;78(18):2054-9, 2006.

  2. Prasain JK, Xu J, Kirk M, Smith Johnson M, Sfakianos J, Barnes S.
    Differential biliary excretion of genistein metabolites following intraduodenal and intravenous infusion of genistin in female rats.
    J Nutr. 136:2975-9, 2006.

  3. D'Alessandro, TL., Boersma-Maland, BJ., Peterson, TG., Sfakianos, J., Prasain, JK., Patel RP, Darley-Usmar VM, Botting NP, Barnes S.
    Metabolism of phytoestrogen conjugates.
    Methods Enzymol. 400, 316-42, 2005.

  4. Meezan, E., Meezan, E., Jones, K., Moore, R., Barnes, S., Prasain, J.
    Contrasting effects of puerarin and daidzin on glucose homeostasis in mice.
    Journal of Agriculture and Food Chemistry, 53, 8760-8767, 2005.

  5. Peng, N., Clark, J., Prasain, J., White C., Kim, H., Wyss, J.
    Antihypertensive and cognitive effects of grape polyphenols in estrogen-depleted, female, spontaneously hypertensive rats.
    Am J Physiol Regul Integr Comp Physiol. 289: R771-R775, 2005.

  6. Barnes, S., Prasain, J.K.
    Current Progress in the use of Traditional Medicines and Nutraceuticals.
    Current Opinion in Plant Biology 8: 324-328, 2005.

  7. Prasain, J.K., Moore, R., Hurst, J., Barnes, S., van Kuijk, FJGM.
    Electrospray Tandem Mass Spectrometric Analysis of Carotenoids and their Oxidation Products.
    Journal of Mass Spectrometry 40: 916-923, 2005.

  8. Kim, H., Hall, P., Smith, M., Kirk, M., Prasain, J.K., Barnes, S., Grubbs, C.
    Chemoprevention by grape seed extract and genistein in carcinogen-induced mammary cancer in rats is diet-dependent.
    Journal of Nutrition, J Nutr. 134: 3445S-3452S, 2004.

  9. Prasain J.K., Wang C.-C., Barnes S.
    Mass spectrometric methods for the determination of flavonoids in biological samples.
    Free Radical Biology & Medicine, 37: 1324-1350, 2004.

  10. Prasain J.K., Jones K., Brissie, N., Moore D.R. II, Wyss J.M., Barnes S.
    Identification of puerarin and its metabolites in rats by liquid chromatography-tandem mass spectrometry.
    Journal of Agricultural Food Chemistry, 52: 3708-3712, 2004.

  11. Boersma BJ, D'Alessandro T, Benton MR, Kirk M, Wilson LS, Prasain J, Botting NP, Barnes S, Darley-Usmar VM, Patel RP.
    Neutrophil myeloperoxidase chlorinates and nitrates soy isoflavones and enhances their antioxidant properties.
    Free Radical Biology & Medicine, 35:1417-30, 2003.

  12. D'Alessandro T. Prasain J. Benton MR. Botting N. Moore R. Darley-Usmar V. Patel R. Barnes S.
    Polyphenols, inflammatory response, and cancer prevention: chlorination of isoflavones by human neutrophils.
    Journal of Nutrition. 133(11 Suppl 1):3773S-3777S, 2003.

  13. Prasain, J.K., Jones, K., Kirk, M., Wilson, L., Smith-Johnson, M., Weaver, C.M., Barnes, S.
    Profiling and quantification of isoflavonoids in kudzu dietary supplements by high-performance liquid chromatography and electrospray ionization tandem mass spectrometry.
    J Agric Food Chem, 51:4213-4218, 2003.

  14. Prasain JK. Patel R. Kirk M. Wilson L. Botting N. Darley-Usmar VM. Barnes S.
    Mass spectrometric methods for the analysis of chlorinated and nitrated isoflavonoids: a novel class of biological metabolites.
    Journal of Mass Spectrometry. 38:764-771, 2003.

  15. Belenky M. Prasain J. Kim H. Barnes S.
    DING, a genistein target in human breast cancer: a protein without a gene.
    Journal of Nutrition 133(7 Suppl):2497S-2501S, 2003.

  16. Kadota S. Tezuka Y. Prasain JK. Ali MS. Banskota AH.
    Novel diarylheptanoids of Alpinia blepharocalyx.
    Current Topics in Medicinal Chemistry. 3:203-225, 2003.

  17. Wang C.-C., Prasain J.K., Barnes S.
    Review of the methods used in the determination of phytoestrogens.
    J. Chromatogr. B 777: 3-28, 2002.

  18. Prasain JK. Ueki M. Stefanowicz P. Osada H.
    Rapid screening and identification of cytochalasins by electrospray tandem mass spectrometry.
    Journal of Mass Spectrometry 37:283-291, 2002.

  19. Prasain JK. Stefanowicz P. Kiyota T. Habeichi F. Konishi Y.
    Taxines from the needles of Taxus wallichiana.
    Phytochemistry. 58:1167-70, 2001

  20. Stefanowicz P. Prasain JK. Yeboah KF. Konishi Y.
    Detection and partial structure elucidation of basic taxoids from Taxus wallichiana by electrospray ionization tandem mass spectrometry.
    Analytical Chemistry. 73:3583-3589, 2001

  21. K. Sekiya, Y. Tezuka, K. Tanaka, J. K. Prasain, T. Namba, K. Katayama, T. Koizumi, M. Maeda, T. Kondo, S. Kadota.
    Distribution, metabolism and excretion of butylidenephthalide of Ligustici chuanxiong rhizoma in hairless mouse after dermal application.
    J. Ethnopharmacol., 2000,71, 401-409.

  22. J. K. Prasain, J-X. Li, Y. Tezuka, K. Tanaka, P. Basnet, H. Dong, T. Namba, S. Kadota.
    A New Antiplatelet Diarylheptanoid from Alpinia blepharocalyx.
    Planta Med., 1999, 65, 196.

  23. J. K. Prasain, J-X. Li, Y. Tezuka, K. Tanaka, P. Basnet, H. Dong, T. Namba, S. Kadota.
    Calyxin H, Epicalyxin H, and Blepharocalyxins A and B, Novel Diarylheptanoids from the Seeds of Alpinia blepharocalyx.
    J. Nat. Prod., 1998, 61, 212-216.

  24. J. K. Prasain, Y. Tezuka, J-X. Li, K. Tanaka, P. Basnet, H. Dong, T. Namba, S. Kadota.
    Novel Diarylheptanoids from the Seeds of Alpinia blepharocalyx-Revised Structure of Calyxin A.
    J. Chem. Res., (M), 1998, 265-279.

  25. P. Peungvicha, S. S. Thirawrapan, R. Temsiririrkkul, H. Watanabe, J. K. Prasain, S. Kadota.
    4-Hydroxybenzoic acid: A Hypoglycemic Constituent of Aqueous Extract of Pandanus odorus root.
    J. Ethnopharm., 1998, 60, 27-32.

  26. J. K. Prasain, Y. Tezuka, K. Hase, P. Basnet, H. Dong, T. Namba, S. Kadota.
    Inhibitory Effect of Diarylheptanoids on Nitric Oxide Production in Activated Murine macrophages.
    Biol. Pharm. Bull., 1998, 21(4), 371-4.

  27. J. K Prasain
    "Bio-active Novel Diarylheptanoids from Alpinia blepharocalyx K.Schum" - Ph.D Thesis,
    Toyama Medical & Pharmaceutical University, 1998, Japan

  28. J-X. Li, Q. Shi, Q. B. Xiong, J. K. Prasain, Y. Tezuka, T. Hareyama, Z. T. Wang, K. Tanaka, T. Namba, S. Kadota.
    Tribulusamide A and B, new hepatoprotective lignanamides from the fruits of Tribulus terrestris: indications of cytoprotective activity in murine hepatocyte culture.
    Planta Medica., 1998, 64, 628-631.

  29. A. H. Banskota, Y. Tezuka., J. K. Prasain, K. Matsushige, I. Saiki., S. Kadota.
    Chemical Constituents of Brazilian Propolis and their Cytotoxic Activities.
    J. Nat. Prod., 1998, 61, 896-900.

  30. H. Li, J.-X. Li, J. K. Prasain, Y. Tezuka, T. Namba, T. Miyahara, S. Tonam, H. Seto, T. Tada, S. Kadota.
    Antiosteoporotic Activity of the Stem of Sambucus sieboldiana.
    Biol. Pharm. Bull., 1998, 21, 594-598.

  31. J. K. Prasain, Y. Tezuka, J.-X. Li, K. Tanaka, P. Basnet, H. Dong, T. Namba, S. Kadota.
    Six Novel Diarylheptanoids Bearing Chalcone or Flavanone Moiety from the Seeds of Alpinia blepharocalyx.
    Tetrahedron, 1997, 53, 7833-7842.

  32. 26. S. Kadota, J. K. Prasain, J.-X. Li, P. Basnet, H. Dong, T. Tani, T. Namba.
    Blepharocalyxins A and B, Novel Diarylheptanoids from Alpinia blepharocalyx, and their Inhibitory Effect on NO Formation in Murine Macrophages.
    Tetrahedron Lett., 1996, 37, 7283-7286.

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