On this page are a few examples of special processing & embedding done in the CPL.Sainte-Marie processing for immunohistochemistryFixation in cold ethanol and hand processing for IHC (Sainte-Marie G. A paraffin embedding technique for studies employing immunofluorescence. J Histochem Cytochem 10:250-256, 1962)Colitis models for inflammatory bowel disease researchFor these projects, the colon is opened, cut into proximal, middle, and distal segments, and the proximal end of each segment is marked with India ink. The segments are fixed in cassettes using one biopsy pad to prevent curling. After fixation, each segment is trimmed into two strips, which are then embedded with proximal, middle, and distal segments placed side by side in the block. This allows the location and distribution of affected areas to be determined and provides good perpendicular sectioning for evaluation of colitis severity.Experimental autoimmune encephalomyelitis (EAE)Here the spinal column is fixed intact, demineralized, and trimmed into 2 mm thick segments. Segments are positioned in casettes in 3 x 3 arrays between biopsy pads for processing, and are embedded as positioned at trimming. This allows the distribution of lesions over the length of the spinal cord to be determined.
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On April 30, 2015 the Form FDA 1572 on the FDA website at http://www.fda.gov/AboutFDA/ReportsManualsForms/Forms/ListFormsAlphabetically/ is expired.
The FDA is in the process of updating and posting a new Form FDA 1572. Even though it is expired, the FDA approved continued use of the current form.
We will monitor the FDA website and will post notice of the new form's release, when available.