Use a sharp blade such as this one, which has a handle with replaceable blades. Handles and blades are available from vendors of histology and pathology supplies.Tissues must be trimmed to a thickness that will allow them to be completely permeated with paraffin, and to provide the orientation needed. We suggest "thick as a nickel" as a thumb rule. Some mouse organs are small enough that they are best embedded whole.
If there is an area of particular interest, such as a tumor, in the specimen, trim the tissue so that the area of interest is near one surface of the specimen, and place that surface down in the cassette.Be sure to let the histotechs know if the area of interest is very small to ensure that it is not lost or missed. Be advised that it is very difficult to trim and embed tissues so precisely that it can be determined before sectioning which sections will contain such areas. In such cases it is advisable to request serial sectioning and to save all sections until you're certain you've obtained the information you need. Blocks can always be cut deeper, but discarded sections are gone forever.Don't place too many tissues in the cassette. Overcrowding can inhibit proper processing, and it isn't possible to get that many tissues positioned in the block for good sectioning anyway. This one should have about 1/2 or 2/3 of the amount of tissue shown. As a general rule, place tissues of similar consistency together. For example, don't place tough tissues such as skin in the same cassette as soft tissues such as spleen or brain. If the tissues vary greatly in consistency, they may not all section well.If the tissue is very small, biopsy pads can be used to help prevent the specimen from being lost. Biopsy cassettes with fine screens also are available. Biopsy pads also can be used to prevent samples of skin and hollow organs from curling during fixation, but care must be taken not to compress or distort the tissue.In general, biopsy pads should not be used with larger tissue samples. However, they can be used to maintain orientation or positioning of trimmed samples, as distortion is of less concern with fixed solid tissues. (See the examples on the Special processing & embedding page.)
In an effort to streamline the process for both incoming and outgoing federal subawards, UAB has joined the Federal Demonstration Partnership’s (FDP) Expanded Clearinghouse. This is a pilot program for certain FDP institutions and provides audit, demographic and fiscal information needed by pass-through entities (PTEs) when they are issuing federal subawards. Now, when UAB issues a federal subaward to another entity in the pilot program, collection of the Subrecipient Assurance form is no longer required. Instead, the necessary information will be obtained from the entity’s profile in the Expanded Clearinghouse; a searchable list of the participating entities along with their profiles can be found FDP Expanded Clearinghouse website.
Attached is a PDF of the participating institutions. Project-specific information (such as Human Subjects use, Animal Subjects use, etc.) will still need to be collected from the entities including a new, project specific form for that will be released shortly.
For incoming subawards, we will no longer need to complete forms containing this information from other pilot institutions. The FDP web site has sample language to send to other pilot participants when we are asked to complete such forms.
Additional information can be found on the FDP website and will be available shortly the Office of Sponsored Programs website. If you have questions, please contact email@example.com.
On August 24th 2012, financial conflict of interest training became mandatory for all research personnel responsible for the design, conduct or reporting of research. The Federal Final Rule that established this requirement also stipulates that re-training is required every four years. For many investigators, re-training will be required this year. Email notifications will be sent out informing investigators when they need to re-train. Please contact the Office of the Conflict of Interest Review Board (OCIRB) at (205) 975-9691 if you have any questions about re-training.
Join us on Wednesday, August 24 in Spain Auditorium at 4 pm for an open discussion on the implications of the FLSA mandate on postdoc salaries. Deans and Central Administration are investing in a plan that we see as striving to be fair to all our postdocs, while at the same time easing the burden on our investigators in order to minimize disruption to ongoing research programs. We will also discuss the Research Career ladder and its implementation. Event information can be found here.
Expect new features and improvements to be released on August 18, 2016, for the Extramural Trainee Reporting and Career Tracking (xTRACT) system.
Post-release details and screenshots will be made available through Online Help for xTRACT resources. Review the original article in the attached PDF or on the eRA News website.
UAB Comprehensive Cancer Center
18th Annual Research Retreat – Monday, October 17, 2016
Sheraton Hotel Downtown Birmingham
2016 Meeting Theme – Immunotherapeutics
Program Chairs: Ravi Bhatia, M.D. and Harry Erba, M.D., Ph.D.
Meeting Website: http://www3.ccc.uab.edu/index.php/research/research-retreat/
Abstract submission: August 1 – September 16, 2016
Online Registration: August 1 – September 16, 2016
Abstract submission: Monday, August 1 – Friday, September 16, 2016
Eligible participants may submit an abstract of their original cancer research for presentation as a poster in the research competition. First, second, third place and honorable mention awards are presented for the most outstanding posters. Winners receive cash awards. See meeting website for details.
Cancer Research – Open Category (non-award)
Cancer researchers not eligible for participation in an award category are encouraged to submit an abstract for presentation as a poster in the Cancer Research – Open Category. This non-award category offers the opportunity for researchers to discuss their work with meeting participants.
On-line registration: Monday, August 1 – Friday, September 16, 2016
The annual Research Retreat provides the opportunity to stimulate interdisciplinary research collaboration and development among participants. This year’s event features presentations by experts in the field of Immunotherapeutics.
We hope to see you there!
A new version of the UAB Extramural Support Checklist is now available. Revisions include:
Please take this opportunity to download the 8/10/2016 version of the UAB Extramural Support Checklist from the Office of Sponsored Programs Forms webpage.
David Brown, PT, PhD, SHP Department of Physical TherapyDori Pekmezi, PhD, SOPH Department of Health BehaviorCeren Yarar-Fisher, PT, PhD, SOM Department of Physical Medicine & RehabilitationRob Motl, PhD, SHP Department of Physical Therapy
P. Darrell Neufer, PhDDirector, East Carolina Diabetes and Obesity InstituteProfessor, Departments of Physiology and KinesiologyEast Carolina University
Krista Vandenborne, PT, PhDProfessor and Chair, Department of Physical TherapyUniversity of Florida
Scott Trappe, PhDProfessor and Director, Human Performance LaboratoryBall State University
Anne McTiernan, MD, PhDProfessor, Department of Epidemiology, School of Public HealthMember, Fred Hutchinson Cancer Research CenterUniversity of Washington
Mike Roberts, PhDAssistant Professor, School of KinesiologyAuburn University
The NIH Extramural Nexus Updates for July 2016 have been released. Stories highlighted this month include: