Endocrinology journal selected a recent paper from the research lab of UAB Comprehensive Diabetes Center Director Anath Shalev, M.D., as the feature article of the week. As the feature article, the team’s research will stay at the top of the journal home page for the week.
Their featured research discovered that deletion of alpha cell TXNIP improves diabetes-associated hyperglucagonemia and glucose homeostasis. The team used alpha cell TXNIP knockout (aTKO) mice and different mouse models of diabetes and glucose intolerance.
Shalev and her lab have found themselves at the forefront of TXNIP research for over two decades. In particular, their lab has been able to demonstrate that the protein TXNIP plays a central role in the disfunction of islet beta cells, which are key to maintaining glucose control due to their production the hormone insulin.
Now, they have found that the role of TXNIP extends beyond the beta cell and also affects other islet cells.
Before it became the Endocrinology feature article, their research “Alpha Cell Thioredoxin-interacting Protein Deletion Improves Diabetes-associated Hyperglycemia and Hyperglucagonemia” was featured in UAB News in September.
Endocrinology is the flagship basic science journal of the Endocrine Society. Journal editors publish research investigating endocrine function at all levels of biological organization.
All study authors include: