Our clinical trials research program is aimed at testing novel mechanism of action drugs and devices to determine their safety and optimal dosing. These treatments are aimed at populations either not responsive to treatment or at modifying the course of the illness. This work directly relates to our teaching and clinical missions because psychiatrists must understand the process of developing newdrugs fromdiscovery through registration so they can critically evaluate the literature and judge whether and how to introduce new medications and devices into the treatment of their patients.