UAB researchers have preliminary data, with cultured cells or diabetic hearts, that diabetes impairs this removal of dead heart-muscle cells. They believe this impairment may be the reason diabetes increases the risk for cardiovascular disease, including heart failure.
Large, human cardiac-muscle patches created in the lab have been tested for the first time on large animals in a heart attack model. This clinically relevant approach showed that the patches significantly improved recovery from heart attack injury.
Overexpression of CCND2 increased growth and division of grafted heart muscle cells, resulting in better heart function and decreased size of dead tissue.
UAB researchers want to create new treatments for these banes of cardiovascular disease.
A UAB symposium on cardiovascular tissue engineering brought together some of the best in the business in this rapidly developing field of translational medicine.
Biomedical engineering students Jervaughn Hunter and Nikea McMullen are developing a contamination-free stethoscope cover to prevent a common source of infection.
Twelve School of Medicine faculty were recently honored as winners of the UAB Graduate Dean's Excellence in Mentorship Award.
Cardiac muscle patches in this proof-of-concept research may represent an important step toward the clinical use of 3-D-printing technology, as researchers have grown heart tissue by seeding a mix of human cells onto a 1-micron-resolution scaffold made with a 3-D printer.
The collaboration among UAB, University of Wisconsin and Duke University will use bioengineered stem cells and bioengineered tissue to treat heart failure after heart attacks.
Victor J. Dzau, M.D., an expert in cardiovascular medicine and genetics, will present at the 2016 Frontiers of Cardiovascular Tissue Engineering Seminar at UAB on Friday, August 19.
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