Mood Disorders, such as major depressive disorder and bipolar disorder, represent a group of common and debilitating mental illnesses. While major depressive disorder is the most widespread mood disorder with an approximate lifetime prevalence of 15%, bipolar disorder is a severe form of mood disorder with an estimated prevalence of 2-4%. The World Health Organization has ranked depression and bipolar disorder among the most disabling conditions worldwide.

A group of researchers in the UAB Department of Psychiatry and Behavioral Neurobiology, including Drs. Richard Shelton, Yogesh Dwivedi, Matthew Macaluso, Karen Gamble, Merida Grant, Rachel Fargason, Li Li, and James Cullinan, have developed a wide range of laboratory, clinical, and translational neuroscience projects to investigate the neurobiology and treatment of mood disorders. The objective of this work is to increase our understanding of treatment for these serious conditions leading to improved treatment.